Researchers at Queen Mary University of London have developed a new way to grow mineralised materials which could regenerate hard tissues such as dental enamel and bone.

Enamel, located on the outer part of our teeth, is the hardest tissue in the body and enables our teeth to function for a large part of our lifetime despite biting forces, exposure to acidic foods and drinks and extreme temperatures. This remarkable performance results from its highly organised structure.

However, unlike other tissues of the body, enamel cannot regenerate once it is lost, which can lead to pain and tooth loss. These problems affect more than 50 per cent of the world’s population and so finding ways to recreate enamel has long been a major need in dentistry.

Weight gain has often been noted as a side effect of quitting smoking, and research has well established that nicotine can function as an appetite suppressant. A new study has now uncovered a novel mechanism showing how nicotine directly activates a protein that signals a type of fat cell to start burning energy.

A few years ago, scientists discovered a new, third type of fat cell called beige fat. This important discovery revealed an entirely new metabolic target for obesity research. Along with brown fat cells, beige fat was found to rapidly burn calories and generate heat.

Now, new research from the University of Michigan Life Sciences Institute has revealed a novel metabolic mechanism explaining how a protein called CHRNA2 specifically stimulates beige fat cells to burn energy. The study found that CHRNA2 receptor proteins are activated by two molecules – nicotine and acetylcholine.