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Archive for the ‘genetics’ category: Page 21

Oct 10, 2024

Cameron County Preparing For Possible SpaceX Launch

Posted by in categories: biotech/medical, genetics, neuroscience, space travel

Scientists have used gene-editing techniques to boost the repair of nerve cells damaged in multiple sclerosis, a study shows. The innovative method, which was tested in mice, supports the development of cells that can repair the protective myelin coating around nerves, restoring their ability to conduct messages to the brain.

The findings, now published in Nature Communications, offer a potential route for future treatments to stop disability progression, experts say.

Our bodies have the ability to repair myelin, but in multiple sclerosis (MS), and as we age, this becomes less effective. There are currently no treatments to boost this process.

Oct 10, 2024

‘Pause Button’ Molecule Uncovered in Human Embryos

Posted by in categories: biotech/medical, food, genetics, health

Mamma bears press pause on their early pregnancies, so that their cubs are born closer to a food filled spring. Researchers led by a team in Germany have now found this same pregnancy pause button exists in human cells too.

“Although we have lost the ability to naturally enter dormancy, these experiments suggest that we have nevertheless retained this inner ability and could eventually unleash it,” says molecular geneticist Nicolas Rivron from the Austrian Academy of Sciences (IMBA).

“Triggering a dormant state during an IVF procedure could provide a larger time window to assess embryo health and to synchronize it with the mother for better implantation inside the uterus.”

Oct 10, 2024

Bioengineered enzyme can produce synthetic genetic material, advancing development of new therapeutic options

Posted by in categories: bioengineering, biotech/medical, genetics

A research team led by the University of California, Irvine has engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

Oct 10, 2024

Improved prime editing system makes gene-sized edits in human cells at therapeutic levels

Posted by in categories: biotech/medical, genetics

“It’s exciting to see the high efficiency and versatility of eePASSIGE, which could enable a new category of genomic medicines,” added Gao. “We also hope that it will be a tool that scientists from across the research community can use to study basic biological questions.”

Prime improvements

Many scientists have used prime editing to efficiently install changes to DNA that are up to dozens of base pairs in length, sufficient to correct the vast majority of known pathogenic mutations. But introducing entire healthy genes, often thousands of base pairs long, in their native location in the genome has been a long-standing goal of the gene-editing field. Not only could this potentially treat many patients regardless of which mutation they have in a disease-causing gene, but it would also preserve the surrounding DNA sequences, which would increase the likelihood that the newly installed gene is properly regulated, rather than expressed too much, too little, or at the wrong time.

Oct 9, 2024

Did the building blocks of life replicate on their own?

Posted by in category: genetics

Researchers have identified a plausible geological setting in which nucleic acids, the fundamental building blocks of genetic material, could have replicated on their own, potentially giving rise to life on Earth.

The study, published as a reviewed preprint in the journal eLife, shows how a simple interaction between gas flow and water in a narrow rock channel could create the physical conditions necessary for nucleic acid replication.

The work offers insights that may interest scientists exploring the origins of life as well as applications in nucleic acid research and diagnostics.

Oct 8, 2024

Uncovering Genetic Links to Psychiatric Disorders in the Brain

Posted by in categories: biotech/medical, genetics, neuroscience

Summary: Scientists have identified how genetic variants influence the risk of neurological and psychiatric disorders, including schizophrenia and autism. Using live neural cells and DNA sequencing, researchers discovered thousands of “non-coding” genetic variants with context-dependent functions, activated during brain development.

These variants act like switches, turning genes on or off depending on cellular pathways. This research offers new insights into the biological mechanisms behind psychiatric disorders and could lead to personalized treatments based on genetic profiles.

Oct 6, 2024

The Study No One Talks About

Posted by in categories: biotech/medical, genetics, media & arts

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Oct 4, 2024

Targeting Glucose May Spark Neurogenesis

Posted by in categories: biotech/medical, genetics, neuroscience

Summary: Neural stem cells, which create new neurons in the brain, become less active with age due to elevated glucose levels. Researchers found that by knocking out the glucose transporter gene GLUT4 in older mice, they could significantly increase the production of new neurons.

This discovery opens up potential pathways for both genetic and behavioral interventions to stimulate brain repair, including the possibility of a low-carbohydrate diet. The findings could help treat neurodegenerative diseases and aid in brain recovery after injury.

Oct 3, 2024

Vision loss: Is gene therapy the answer?

Posted by in categories: biotech/medical, genetics, health

Diseases that affect the retina, the light-sensitive layer at the back of the eye, are a significant cause of visual impairment and blindness. Gene therapy holds promise for treating some of these conditions, and current research advances may soon shift the therapeutic landscape for eye health. However, many obstacles remain in place, as this Special Feature discusses.

Gene therapy uses genetic material, either DNA or RNA, to treat or prevent the progression of a disease. It often involves the introduction of genetic material into a person’s cells to replace a defective or missing gene.

Although early attempts at gene therapy have been effective in achieving the expression of the therapeutic gene in the target tissue, they have also been accompanied by severe adverse effects.

Oct 3, 2024

Scientists Engineer Yellow-seeded Camelina with High Oil Output

Posted by in categories: biotech/medical, food, genetics

UPTON, N.Y. — Efforts to achieve net-zero carbon emissions from transportation fuels are increasing demand for oil produced by nonfood crops. These plants use sunlight to power the conversion of atmospheric carbon dioxide into oil, which accumulates in seeds. Crop breeders interested in selecting plants that produce a lot of oil look for yellow seeds. In oilseed crops like canola, yellow-seeded varieties generally produce more oil than their brown-seeded counterparts. The reason: The protein responsible for brown seed color — which yellow-seeded plants lack — also plays a key role in oil production.

Now, plant biochemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory — who are interested in increasing plant oil synthesis for the sustainable production of biofuels and other bioproducts — have harnessed this knowledge to create a new high-yielding oilseed crop variety. In a paper just published in The Plant Biotechnology Journal, they describe how they used tools of modern genetics to produce a yellow-seeded variety of Camelina sativa, a close relative of canola, that accumulates 21.4% more oil than ordinary camelina.

“If breeders can get a few percent increase in oil production, they regard it as significant, because even small increases in yield can lead to large increases in oil production when you’re planting millions of acres,” said Brookhaven Lab biochemist John Shanklin, chair of the Lab’s Biology Department and leader of its plant oil research program. “Our nearly 22% increase was unexpected and could potentially result in a dramatic increase in production,” he said.

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