Researchers have gained new insights into an ion channel from algae. These insights could help optogenetics realize its full potential in the future.
Category: genetics – Page 4
Gut microbiota linked to autism spectrum disorder progression in mice
Autism spectrum disorder (ASD) affects an estimated 1 in 31 children in the United States by 2025, and prevalence in East Asian countries, such as South Korea, Singapore, and Japan, may be even higher than those in the United States. Despite its increasing prevalence, the underlying causes of ASD remain poorly understood, and there are currently no curative, preventive, or treatment options available.
A research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, who also serves as the CEO of ImmunoBiome, has made a discovery that reveals a multi-faceted mechanism behind ASD. This study, published in the July issue of Nature Communications, in collaboration with Dr. John C. Park and Prof. Tae-Kyung Kim, demonstrates that the gut microbiota and host immune system together can influence the progression of ASD in a genetic mouse model.
ASD has long been regarded as a genetically driven disorder. However, growing evidence suggests that environmental and microbial factors also play a role. The human gut harbors more than ten times as many microbial cells as human cells, and these microbes play vital roles in metabolism and the development of the immune system.
Recreating a Rare Mutation Could Grant Almost Universal Virus Immunity For Days
A rare genetic mutation appears to make people basically invulnerable to viruses – and it could potentially be harnessed as a therapy. Researchers have now shown this surprising viral protection can be replicated in mice and hamsters.
“We have yet to find a virus that can break through the therapy’s defenses [in cell culture tests],” explains Columbia University immunologist Dusan Bogunovic, who first discovered this unusual antiviral superpower 13 years ago.
The mutation, a deficiency in interferon-stimulated gene 15 (ISG15), causes a mild yet persistent inflammation across the body. Examining patients’ immune cells revealed they’d had the usual run of encounters with flu, measles, chickenpox, and mumps, yet they’d never reported feeling particularly ill as a result.
First-Of-Its-Kind Cell Transplant Brings a Cure For Diabetes Closer
A patient with type 1 diabetes has begun producing his own insulin after receiving a transplant of pancreatic cells.
For the first time in humans, these islet cells have been genetically edited so they wouldn’t be rejected by the patient, removing the need for immunosuppressant drugs.
Type 1 diabetes usually begins when the immune system mistakenly attacks the islet cells in the pancreas, which are responsible for producing insulin. The condition is usually managed with a careful diet and regular insulin injections, but an emerging treatment involves replacing the damaged islet cells with functional ones.
One Fruit, 1600 Compounds, Countless Health Benefits
Fresh grapes contain a potent mix of over 1,600 compounds that benefit heart, brain, skin, and gut health. New evidence suggests they deserve official superfood recognition, with benefits even at the genetic level.
A new article appearing in the current issue of the peer-reviewed Journal of Agriculture and Food Chemistry explores the concept of “superfoods” and makes a case that fresh grapes have earned what should be a prominent position in the superfood family. The author, leading resveratrol and cancer researcher John M. Pezzuto, Ph.D., D.Sc., Dean of the College of Pharmacy and Health Sciences at Western New England University, brings forth an array of evidence to support his perspective on this issue.
As noted in the article, the term “superfood” is a common word without an official definition or established criteria. Mainstream superfoods are typically part of the Mediterranean Diet and generally rich in natural plant compounds that are beneficial to a person’s health. Pezzuto addresses the broader topic of superfoods in detail, then makes the scientific case for grapes, noting that fresh grapes are underplayed in this arena and often not included with mention of other similar foods, such as berries.
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A research team headed by the University of Zurich has developed a powerful new method to precisely edit DNA by combining cutting-edge genetic engineering with artificial intelligence. This technique opens the door to more accurate modeling of human diseases and lays the groundwork for next-generation gene therapies.
Precise and targeted DNA editing by small point mutations as well as the integration of whole genes via CRISPR/Cas technology has great potential for applications in biotechnology and gene therapy. However, it is very important that the so-called gene scissors do not cause any unintended genetic changes, but maintain genomic integrity to avoid unintended side effects. Normally, double-stranded breaks in the DNA molecule are accurately repaired in humans and other organisms. But occasionally, this DNA end joining repair results in genetic errors.
Gene editing with greatly improved precision Now, scientists from the University of Zurich (UZH), Ghent University in Belgium and the ETH Zurich have developed a new method which greatly improves the precision of genome editing. Using artificial intelligence (AI), the tool called Pythia predicts how cells repair their DNA after it is cut by gene editing tools such as CRISPR/Cas9. “Our team developed tiny DNA repair templates, which act like molecular glue and guide the cell to make precise genetic changes,” says lead author Thomas Naert, who pioneered the technology at UZH and is currently a postdoc at Ghent University.
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Attempting To Slow Aging By Optimizing Biomarkers
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