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Archive for the ‘genetics’ category: Page 444

Oct 1, 2014

The Abolition of Medicine as a Goal for Humanity 2.0

Posted by in categories: biological, bionic, biotech/medical, ethics, futurism, genetics, homo sapiens, human trajectories, life extension, philosophy, policy, transhumanism

What follows is my position piece for London’s FutureFest 2013, the website for which no longer exists.

Medicine is a very ancient practice. In fact, it is so ancient that it may have become obsolete. Medicine aims to restore the mind and body to their natural state relative to an individual’s stage in the life cycle. The idea has been to live as well as possible but also die well when the time came. The sense of what is ‘natural’ was tied to statistically normal ways of living in particular cultures. Past conceptions of health dictated future medical practice. In this respect, medical practitioners may have been wise but they certainly were not progressive.

However, this began to change in the mid-19th century when the great medical experimenter, Claude Bernard, began to champion the idea that medicine should be about the indefinite delaying, if not outright overcoming, of death. Bernard saw organisms as perpetual motion machines in an endless struggle to bring order to an environment that always threatens to consume them. That ‘order’ consists in sustaining the conditions needed to maintain an organism’s indefinite existence. Toward this end, Bernard enthusiastically used animals as living laboratories for testing his various hypotheses.

Historians identify Bernard’s sensibility with the advent of ‘modern medicine’, an increasingly high-tech and aspirational enterprise, dedicated to extending the full panoply of human capacities indefinitely. On this view, scientific training trumps practitioner experience, radically invasive and reconstructive procedures become the norm, and death on a physician’s watch is taken to be the ultimate failure. Humanity 2.0 takes this way of thinking to the next level, which involves the abolition of medicine itself. But what exactly would that mean – and what would replace it?

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Sep 29, 2014

Towards a ‘Right to Science’

Posted by in categories: ethics, genetics, government, law, philosophy, policy, science

In 1906 the great American pragmatist philosopher William James delivered a public lecture entitled, ‘The Moral Equivalent of War’. James imagined a point in the foreseeable future when states would rationally decide against military options to resolve their differences. While he welcomed this prospect, he also believed that the abolition of warfare would remove an important pretext for people to think beyond their own individual survival and toward some greater end, perhaps one that others might end up enjoying more fully. What then might replace war’s altruistic side?

It is telling that the most famous political speech to adopt James’ title was US President Jimmy Carter’s 1977 call for national energy independence in response to the Arab oil embargo. Carter characterised the battle ahead as really about America’s own ignorance and complacency rather than some Middle Eastern foe. While Carter’s critics pounced on his trademark moralism, they should have looked instead to his training as a nuclear scientist. Historically speaking, nothing can beat a science-led agenda to inspire a long-term, focused shift in a population’s default behaviours. Louis Pasteur perhaps first exploited this point by declaring war on the germs that he had shown lay behind not only human and animal disease but also France’s failing wine and silk industries. Moreover, Richard Nixon’s ‘war on cancer’, first declared in 1971, continues to be prosecuted on the terrain of genomic medicine, even though arguably a much greater impact on the human condition could have been achieved by equipping the ongoing ‘war on poverty’ with comparable resources and resoluteness.

Science’s ability to step in as war’s moral equivalent has less to do with whatever personal authority scientists command than with the universal scope of scientific knowledge claims. Even if today’s science is bound to be superseded, its import potentially bears on everyone’s life. Once that point is understood, it is easy to see how each person could be personally invested in advancing the cause of scientific research. In the heyday of the welfare state, that point was generally understood. Thus, in The Gift Relationship, perhaps the most influential work in British social policy of the past fifty years, Richard Titmuss argued, by analogy with voluntary blood donation, that citizens have a duty to participate as research subjects, but not because of the unlikely event that they might directly benefit from their particular experiment. Rather, citizens should participate because they would have already benefitted from experiments involving their fellow citizens and will continue to benefit similarly in the future.

However, this neat fit between science and altruism has been undermined over the past quarter-century on two main fronts. One stems from the legacy of Nazi Germany, where the duty to participate in research was turned into a vehicle to punish undesirables by studying their behaviour under various ‘extreme conditions’. Indicative of the horrific nature of this research is that even today few are willing to discuss any scientifically interesting results that might have come from it. Indeed, the pendulum has swung the other way. Elaborate research ethics codes enforced by professional scientific bodies and university ‘institutional review boards’ protect both scientist and subject in ways that arguably discourage either from having much to do with the other. Even defenders of today’s ethical guidelines generally concede that had such codes been in place over the past two centuries, science would have progressed at a much slower pace.

The other and more current challenge to the idea that citizens have a duty to participate in research comes from the increasing privatisation of science. If a state today were to require citizen participation in drug trials, as it might jury duty or military service, the most likely beneficiary would be a transnational pharmaceutical firm capable of quickly exploiting the findings for profitable products. What may be needed, then, is not a duty but a right to participate in science. This proposal, advanced by Sarah Chan at the University of Manchester’s Institute for Bioethics, looks like a slight shift in legal language. But it is the difference between science appearing as an obligation and an opportunity for the ordinary citizen. In the latter case, one does not simply wait for scientists to invite willing subjects. Rather, potential subjects are invited to organize themselves and lobby the research community with their specific concerns. In our recent book, The Proactionary Imperative, Veronika Lipinska and I propose the concept of ‘hedgenetics’ to capture just this prospect for those who share socially relevant genetic traits. It may mean that scientists no longer exert final control over their research agenda, but the benefit is that they can be assured of steady public support for their work.

Aug 29, 2014

Open Source SynBio?

Posted by in categories: biological, biotech/medical, genetics, open source, posthumanism, transhumanism
If the controversy over genetically modified organisms (GMOs) tells us something indisputable, it is this: GMO food products from corporations like Monsanto are suspected to endanger health. On the other hand, an individual’s right to genetically modify and even synthesize entire organisms as part of his dietary or medical regimen could someday be a human right.
The suspicion that agri-giant companies do harm by designing crops is legitimate, even if evidence of harmful GMOs is scant to absent. Based on their own priorities and actions, we should have no doubt that self-interested corporations disregard the rights and wellbeing of local producers and consumers. This makes agri-giants producing GMOs harmful and untrustworthy, regardless of whether individual GMO products are actually harmful.

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Aug 2, 2014

The Game Theory of Life

Posted by in categories: DNA, genetics

By: Emily Singer — Quanta Magazine

Applying game theory to the behavior of genes provides a new view of natural selection.

In what appears to be the first study of its kind, computer scientists report that an algorithm discovered more than 50 years ago in game theory and now widely used in machine learning is mathematically identical to the equations used to describe the distribution of genes within a population of organisms. Researchers may be able to use the algorithm, which is surprisingly simple and powerful, to better understand how natural selection works and how populations maintain their genetic diversity.

By viewing evolution as a repeated game, in which individual players, in this case genes, try to find a strategy that creates the fittest population, researchers found that evolution values both diversity and fitness.

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Jul 4, 2014

GMOs are not the problem, per se

Posted by in categories: biotech/medical, business, existential risks, food, genetics, health, innovation

. @hjbentham . @clubofinfo . @dissidentvoice_ .#tech .#gmo .#ethics . @ieet .

Since giving my support to the May 24 march against Monsanto, I have taken the time to review some of the more unusual opinions in the debate over genetically-modified organisms (GMOs). The enthusiasts for technological development as a means of eliminating scarcity and disparity view GMOs favorably. These enthusiasts include Ramez Naam, whose book The Infinite Resource (2013) argues for human ingenuity as a sufficient force to overcome all resources shortages.
On the other end of the spectrum, alarmists like Daniel Estulin and William Engdahl argue that GMOs are actually part of a deliberate plot to burden poor nations and reduce their populations by creating illness and infertility. Such fringe figures in the alter-globalization movement regard big pharmaceutical companies, chemical companies and agri-giants as involved in a conspiracy to create a docile and dependent population. Are the opinions of either Naam or Estulin well-informed, or are they both too sensational?

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May 25, 2014

The Lifeboat Foundation Worldwide Ambassador Mr. Andres Agostini’s own White Swan Dictionary, Countermeassuring Every Unthinkable Black Swan, at http://lifeboat.com/blog/2014/04/white-swan

Posted by in categories: big data, biological, business, complex systems, computing, defense, disruptive technology, economics, education, engineering, existential risks, finance, genetics, information science, innovation, internet, law, law enforcement, lifeboat, physics, robotics/AI, science, scientific freedom, security, singularity, supercomputing, sustainability

The Lifeboat Foundation Worldwide Ambassador Mr. Andres Agostini’s own White Swan Dictionary, Countermeassuring Every Unthinkable Black Swan, at https://russian.lifeboat.com/blog/2014/04/white-swan

035

WHITE SWAN — UNABRIDGED DICTIONARY

Altogetherness.— Altogetherness is the quality of conforming to the ability to investigate with all or everything included.

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May 21, 2014

VIRUS: Rebutting the fear of synthetic biology @HJBentham @IEET

Posted by in categories: biological, biotech/medical, disruptive technology, economics, energy, ethics, existential risks, futurism, genetics, science

- @ClubOfINFO — A recent massive leap forward in synthetic life, recently published in Nature, is the expansion of the alphabet of DNA to six letters rather than four, by synthetic biologists – the technicians to whom we entrust the great task of reprogramming life itself.

Breakthroughs such as the above are quite certain to alert more and more people to synthetic biology and its possible consequences. For as long as such breathtaking discoveries continue to be made in this area of research, it is inevitable that latent fears among society will come closer to the surface.
There is likely to be a profound distrust, whether inculcated by religion or by science fiction horror movies and literature, towards the concept of tampering with nature and especially the very building blocks that brought us into existence. While the people with this profoundly negative reaction are not sure what they are warning against, they are motivated by a vitalistic need to believe that the perversion of life is going to provoke hidden – almost divine – repercussions.
Is it really true that no-one should be meddling with something so fundamental to life, or is synthetic biology the science of our century, our civilization’s key to unlimited energy? Whatever the answer may be, the science enabling it already exists and is growing rapidly, and history seems to show that any technology once invented is impossible to contain.
The fact that synthetic base pairs now exist should confirm, for many, the beginning of humanity’s re-engineering of the structures of life itself. As it is unprecedented in our evolution, we are presented with an ethical question and all points of view should be considered, no matter how radical or conservative they are.

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Apr 23, 2014

Book Review: The Human Race to the Future by Daniel Berleant (2013) (A Lifeboat Foundation publication)

Posted by in categories: alien life, asteroid/comet impacts, biotech/medical, business, climatology, disruptive technology, driverless cars, drones, economics, education, energy, engineering, ethics, evolution, existential risks, food, futurism, genetics, government, habitats, hardware, health, homo sapiens, human trajectories, information science, innovation, life extension, lifeboat, nanotechnology, neuroscience, nuclear weapons, philosophy, policy, posthumanism, robotics/AI, science, scientific freedom, security, singularity, space, space travel, sustainability, transhumanism

From CLUBOF.INFO

The Human Race to the Future (2014 Edition) is the scientific Lifeboat Foundation think tank’s publication first made available in 2013, covering a number of dilemmas fundamental to the human future and of great interest to all readers. Daniel Berleant’s approach to popularizing science is more entertaining than a lot of other science writers, and this book contains many surprises and useful knowledge.

Some of the science covered in The Human Race to the Future, such as future ice ages and predictions of where natural evolution will take us next, is not immediately relevant in our lives and politics, but it is still presented to make fascinating reading. The rest of the science in the book is very linked to society’s immediate future, and deserves great consideration by commentators, activists and policymakers because it is only going to get more important as the world moves forward.

The book makes many warnings and calls for caution, but also makes an optimistic forecast about how society might look in the future. For example, It is “economically possible” to have a society where all the basics are free and all work is essentially optional (a way for people to turn their hobbies into a way of earning more possessions) (p. 6–7).

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Apr 1, 2014

The White Swan’s Beyond Eureka and Sputnik Moments! [TREATISE EXCERPT] By Mr. Andres Agostini at www.AMAZON.com/author/agostini

Posted by in categories: 3D printing, alien life, astronomy, automation, big data, biological, bionic, bioprinting, biotech/medical, business, chemistry, climatology, complex systems, computing, cosmology, counterterrorism, cybercrime/malcode, cyborgs, defense, disruptive technology, driverless cars, drones, economics, education, energy, engineering, environmental, ethics, evolution, existential risks, exoskeleton, finance, food, futurism, genetics, geopolitics, government, habitats, hardware, health, homo sapiens, human trajectories, information science, innovation, internet, law, law enforcement, life extension, lifeboat, military, mobile phones, nanotechnology, neuroscience, open access, open source, philosophy, physics, policy, posthumanism, privacy, robotics/AI, science, scientific freedom, security, singularity, space, supercomputing, surveillance, sustainability, transhumanism, transparency, transportation

The White Swan’s Beyond Eureka and Sputnik Moments: How To Fundamentally Cope With Corporate Litmus Tests and With The Permanent Impact of the Dramatic Highly Improbable And Succeed and Prevail Through Transformative and Integrative Risk Management! [TREATISE EXCERPT]. By © Copyright 2013, 2014 Mr. Andres Agostini — All Rights Reserved Worldwide — « www.linkedin.com/in/andresagostini AND www.AMAZON.com/author/agostini » — The Lifeboat Foundation Global Chief Consulting Officer and Partner, Lifeboat Foundation Worldwide Ambassador —

(An Independent, Solemn, Most-Thorough and Copyrighted Answer. Independence, solemnity, thoroughness, completeness, detail, granularity of details, accuracy and rigor, hereunder, will be then redefined by several orders of nonlinear magnitude and without a fail).

[TREATISE EXCERPT].

To Nora, my mother, who rendered me with the definitiveness to seek the thoughts and seek the forethoughts to outsmart any impending demand and other developments. To Francisco, my father: No one who has taught me better. There is no one I regard most highly. It is my greatest fortune to be his son. He endowed me with the Agostini family’s charter, “…Study and, when grown up, you will neither be the tyrants’ toy, nor the passions’ servile slave…” I never enjoyed a “…Mom…”, but considerably enjoyed a gargantuan courageous Mother, Father, Grandparents and Forbears.

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Mar 8, 2014

‘Faxing’ Life from Mars: Craig Venter’s Wild, Digital Space Exploration Idea

Posted by in categories: alien life, genetics, space

By Leonard David, Space.com’s Space Insider Columnist

Craig VenterIf scientists do find life on Mars, it may be possible to beam Martian DNA back to Earth, according to a new idea growing in popularity. If Martian bugs are found, the idea of “faxing” life from Mars is an enticing prospect, spurred on by scientist, Craig Venter, famous for his early sequencing of the human genome.

Venter proposes that researchers analyze Martian DNA on the Red Planet and then radio back that sequence to synthesize the DNA on Earth. He put forth the notion in a book published last year called “Life at the Speed of Light: From the Double Helix to the Dawn of the Digital Age.” [The Search for Life on Mars (A Photo Timeline)]

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