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Archive for the ‘genetics’ category: Page 5

Jun 5, 2019

Harvard breakthrough shows stem cells can be genetically edited in the body

Posted by in categories: biotech/medical, genetics

We owe our long lives to stem cells, which are nestled deep inside certain tissues in the body and constantly replace old cells. In recent years scientists have been able to correct genetic diseases by removing these stem cells, editing their genomes and then implanting them back into the patient, but that adds complications. Now, new research led by Harvard scientists has successfully edited the genes of stem cells while still in the body.

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Jun 3, 2019

CRISPR baby mutation significantly increases mortality

Posted by in categories: biotech/medical, genetics

Six months ago, a Chinese scientist announced that he had edited the genomes of two babies born last year. The germline edits with CRISPR-Cas9 supposedly changed the CCR5 gene to prevent HIV from invading immune cells. An analysis of records in the U.K. Biobank shows that having two copies of this mutation is associated with a 21 percent increase in mortality.

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Jun 3, 2019

New Gene-Editing Method Could Lead To “Creation of a Super-Baby”

Posted by in categories: biotech/medical, genetics

“The technology is similar to weapons and drugs…creation of a super-baby should be banned forever.”


The scientist behind the tech is calling for a ban.

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Jun 3, 2019

First gene-edited babies may be at risk of early death

Posted by in category: genetics

In 2018, a Chinese researcher shocked the world by announcing the birth of two gene-edited babies. The mutations may have hurt, not helped.

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Jun 2, 2019

BioViva Sciences Inc Photo

Posted by in categories: genetics, life extension

BioViva warmly welcomes Dr de Magalhaes to our Scientific Advisory Board!

Dr de Magalhaes graduated in Microbiology in 1999 from the Escola Superior de Biotecnologia in his hometown of Porto, Portugal, and then obtained his PhD in 2004 from the University of Namur in Belgium. Following a postdoc with genomics pioneer Prof George Church at Harvard Medical School, in 2008 Dr de Magalhaes was recruited to the University of Liverpool. He now leads the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/) which focuses on understanding the genetic, cellular, and molecular mechanisms of ageing. Dr de Magalhaes has authored over 100 publications and given over 100 invited talks, including three TEDx talks.

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Jun 2, 2019

Dr. Camillo Ricordi, M.D. — Director, Diabetes Research Institute and Cell Transplant Center, University of Miami — ideaXme — Ira Pastor

Posted by in categories: 3D printing, aging, bioengineering, biotech/medical, business, DNA, genetics, health, life extension, science

May 31, 2019

Is DARPA Planning to Infect Insects with GM Viruses for Use in Food Crops?

Posted by in categories: food, genetics

Continuing from Motherboard, “In an email to Motherboard, a DARPA spokesperson said that four research teams have received allotments of the $45 million funding from the agency as a part of Insect Allies, and that all teams have now entered phase two. The teams include researchers from Penn State University, the University of Texas, and Ohio State University.”

It isn’t difficult to tell what opinion this article represents. Do we need this, or want to trust people with placing genetically modified viruses in the crops that become our grocery store produce?

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May 31, 2019

Drug-resistant cancer cells create own Achilles heel

Posted by in categories: biotech/medical, genetics, sustainability

The cells of most patients’ cancers are resistant to a class of drugs, called proteasome inhibitors, that should kill them. When studied in the lab, these drugs are highly effective, yet hundreds of clinical trials testing proteasome inhibitors have failed. Now scientists may have solved the mystery of these cells’ surprising hardiness. The key: Resistant cancer cells have shifted how and where they generate their energy. Using this new insight, researchers have identified a drug that resensitizes cancer cells to proteasome inhibitors and pinpointed a gene that is crucial for that susceptibility.

As develop, they accrue multiple genetic alterations that allow the cells to quickly reproduce, spread and survive in distant parts of the body, and recruit surrounding cells and tissues to support the growing tumor. To perform these functions, cancer cells must produce high volumes of the proteins that support these processes. The increased production and numerous mutated proteins of cancer cells make them particularly dependent on the proteasome, which is the cell’s protein degradation machine. These huge protein complexes act as recycling machines, gobbling up unwanted proteins and dicing them into their amino acid building blocks, which can be reused for the production of other proteins.

Previously, researchers exploited cancer cells’ increased dependency on their proteasomes to develop anti-cancer therapies that inhibit the proteasomes’ function. Several distinct proteasome inhibitors have been developed, and when used in the lab, these proteasome inhibitor drugs are indeed highly effective at eradicating tumor cells. However, when administered to animal models or patients with cancer, such as multiple myeloma, proteasome inhibitors have limited efficacy and even initially vulnerable cancer cells quickly develop resistance to them. How do cancer cells so adroitly sidestep drugs that should kill them?

Continue reading “Drug-resistant cancer cells create own Achilles heel” »

May 31, 2019

Two new studies strengthen the gut-brain connection in autism

Posted by in categories: biotech/medical, genetics, neuroscience

Two studies are shedding light on the links between the gut, the brain, and autism. The research reveals how gut problems can be triggered by the same gene mutations associated with autism, and a study shows how a fecal transplant from humans with autism can promote autism-like behaviors in mice.

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May 30, 2019

ideaXme — Patricia Weltin — Founder — Beyond the Diagnosis

Posted by in categories: aging, architecture, biotech/medical, business, DNA, economics, education, finance, genetics, health
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