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Archive for the ‘genetics’ category: Page 7

Mar 22, 2019

CRISPR/Cas9 therapy can suppress aging, enhance health and extend life span in mice

Posted by in categories: biotech/medical, genetics, life extension

The findings, published on February 18, 2019 in the journal Nature Medicine, highlight a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. This treatment provides important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy.

“Aging is a complex process in which cells start to lose their functionality, so it is critical for us to find effective ways to study the molecular drivers of aging,” says Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper. “Progeria is an ideal aging model because it allows us to devise an intervention, refine it and test it again quickly.”

With an early onset and fast progression, progeria is one of the most severe forms of a group of degenerative disorders caused by a mutation in the LMNA gene. Both mice and humans with progeria show many signs of aging, including DNA damage, cardiac dysfunction and dramatically shortened life span. The LMNA gene normally produces two similar proteins inside a cell: lamin A and lamin C. Progeria shifts the production of lamin A to progerin. Progerin is a shortened, toxic form of lamin A that accumulates with age and is exacerbated in those with progeria.

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Mar 22, 2019

Dr. John LaMattina — Former President Pfizer Global R&D; Partner PureTech Ventures — IdeaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, business, DNA, genetics, health, life extension, science, transhumanism

Mar 21, 2019

NMN, NAD+ and the Plasma Membrane

Posted by in categories: biotech/medical, genetics, life extension, robotics/AI

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. This conference was designed to bring together the best in the aging research and biotech investment worlds and saw a range of industry experts sharing their insights.

Joe Betts Lacroix of Y Combinator and Vium discusses the different ways in which entrepreneurs can focus on overcoming the diseases of aging, namely direct, indirect, and money-first approaches, and the strengths and weakness of each.

Joe was the primary technical founder of hardware/software startup OQO, which entered the Guinness Book of World Records for building the smallest fully featured PC. His experience spans from biotech research to electronics design. Very experienced in invention, prosecution and monetization of intellectual property, he has over 80 patents granted and pending in fields ranging from biophysics and safety systems to antennas, thermal systems, user interfaces, and analog electronics. He has written numerous peer-reviewed publications in fields such as biophysics, genetics, electronics, and robotics. Joe holds a Harvard A.B., an MIT S.M. and a Caltech research fellowship.

Continue reading “NMN, NAD+ and the Plasma Membrane” »

Mar 21, 2019

Beyond Metformin For Aging — Jahahreeh Finley — IdeaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, cryonics, futurism, genetics, health, life extension, neuroscience, science

Mar 20, 2019

Local extinction of Southern California mountain lions possible within 50 years

Posted by in categories: existential risks, genetics

Two isolated mountain lion populations in southern California’s Santa Ana and Santa Monica Mountains are at risk of local extinction, perhaps as soon as within 50 years, according to a study published in the journal Ecological Applications.

The study showed the extinction risk is due to low genetic diversity and mortality that affects the stability of the population. Mountain mortality is often caused by humans, but can also result from changes in the environment, such as wildfire and fluctuations in prey density.

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Mar 20, 2019

Partial Cellular Reprogramming to Reverse Cellular Aging

Posted by in categories: biotech/medical, genetics, life extension

We have talked about the potential of partial cellular reprogramming in previous articles, and today, we want to draw attention to a new paper that promises to further refine reversal of epigenetic aging in cells.

As we age, our cells experience alterations to their epigenetic markers, and this changes gene expression, which is proposed to be a primary reason we age. Recently, there has been considerable interest in resetting these epigenetic markers to reverse cellular aging, and this paper builds on that.

Three of the study’s authors, Prof. Vittorio Sebastiano, Jay Sarkar, and Marco Quarta, have founded Turn.bio, a biotech company that is working to bring partial cellular reprogramming to humans. The company is also currently enjoying the leadership of Gary Hudson from Oisin Biotechnologies, who is standing in as CEO to help the company get off the ground and funded.

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Mar 20, 2019

The First Gene-Edited Food Is Now Being Served

Posted by in categories: food, genetics

Calyxt is the first with its gene-edited oil, but several other companies also have edited foods in the works.

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Mar 20, 2019

Researchers Discover DNA Switch for Full Body Regeneration

Posted by in categories: biotech/medical, genetics, life extension

This new method could open a major avenue towards the full regeneration of body parts.


A new study has revealed a method of switching the early growth response of DNA on and off, opening the future possibility of regenerating human body parts with the use of genetic editing.

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Mar 16, 2019

Germline gene-editing research needs rules

Posted by in categories: biotech/medical, genetics

In the wake of CRISPR babies, there is an urgent need to better regulate and debate whether, when and how related research should be done.

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Mar 16, 2019

Pain Control in a Post-Opioid World — Prof. Peter McNaughton FMedSci — IdeaXme — Ira Pastor

Posted by in categories: aging, biotech/medical, business, chemistry, futurism, genetics, health, innovation, life extension, neuroscience
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