БЛОГ

Archive for the ‘genetics’ category: Page 7

Nov 28, 2024

Red Light Therapy Reduces Blood Glucose: Glen Jeffery, PhD

Posted by in categories: biotech/medical, genetics, life extension

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get my labs): https://www.ultalabtests.com/partners/michaellustgarten.

Continue reading “Red Light Therapy Reduces Blood Glucose: Glen Jeffery, PhD” »

Nov 28, 2024

Scientists discover shared genetic foundations between musical rhythm and human language

Posted by in categories: biological, genetics, life extension

Zoom

In a study published Nov. 21 in the journal Nature Human Behaviour, researchers have uncovered significant genetic connections between human language abilities and musical rhythm skills, providing new insights into the biological underpinnings of these fundamental human traits.

The study brought together leading experts in the areas of musicality genetics and language genetics from Vanderbilt University Medical Center in close collaboration with researchers at the Max Planck Institute for Psycholinguistics in the Netherlands.

The study revealed overlapping between rhythm-related skills and language-related traits, including dyslexia. Multiple datasets were used from over 1 million individuals. By applying advanced multivariate methods, the researchers were able to identify common genetic factors and explore their biological and evolutionary significance.

Nov 27, 2024

This gene-editing discovery could rejuvenate an ageing brain

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Zoom

CRISPR is a way off being used in human therapeutics, but a new discovery could unlock its potential.

Nov 27, 2024

Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

Posted by in categories: genetics, life extension

Zoom

The molecular and cellular mechanisms underlying ovarian aging are incompletely understood. Here the authors provide single-nuclei RNA and ATAC-seq of human ovarian tissue from four young and four reproductively aged donors, revealing coordinated transcriptomic and epigenomic changes across cell types and highlighting a role for mTOR signaling in reproductive aging.

Nov 27, 2024

Small Molecule Found to Weaken Immune Cells in Lung Cancer

Posted by in categories: biotech/medical, genetics, health, neuroscience

Zoom

To maintain a healthy immune system, doctors advise patients to take vitamins and minerals. Vitamins have many functions that benefit the body, including resisting infection, energy boost, aiding in blood clotting, improving brain function, generation of red blood cells, promoting a healthy gut microbiome, improving wound healing, preventing eye deterioration, and developing strong bones. We can get vitamins from various sources, including orange juice, which is rich in vitamin C, folate, and potassium. Physicians often recommend supplements for patients low on specific vitamins. However, dysregulation of vitamins can weaken the immune system and promote overall bad health. One vitamin in particular that helps maintain cellular function includes B12. This vitamin is essential to generate DNA and red blood cells, and aids in nerve function, energy conversion, and protein metabolism. When a patient has a B12 deficiency it can result in muscle weakness, numbness in hands and feet, difficulty walking, nausea, loss of appetite, and unintentional weight loss. In addition, it can allow the buildup of a small molecule known as methylmalonic acid (MMA).

In healthy tissues, vitamin B12 helps break down MMA. In B12 deficient patients, MMA is increased and can be measured through blood or urine samples. Methylmalonic acid is produced when proteins in your muscle, known as amino acids, are broken down. Tests to determine B12 deficiency or a genetic disorder are done by physicians at birth and after the appearance of symptoms related to B12 deficiency. Interestingly, a group of scientists have discovered a new deleterious role of MMA in lung carcinoma.

A recent publication from Oncogene, by Dr. Ana P. Gomes and others, demonstrated that MMA in aged patients weakens immune cell function and promotes lung cancer progression. Gomes is a professor of molecular oncology at Moffitt Cancer Center in Florida. Her work specifically focuses on understanding metabolic changes as we age and how this change in metabolism influences cancer risk.

Nov 27, 2024

Labeling cell particles with barcodes

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Zoom

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology. The particles, known as small extracellular vesicles (sEVs), play an important role in the spread of disease and as potential drug carriers. The newly developed system, named CIBER, enables thousands of genes to be studied at once, by labeling sEVs with a kind of RNA “barcode.” With this, researchers hope to find what factors are involved in sEV release from host cells. This will help advance our understanding of basic sEV biology and may aid in the development of new treatments for diseases, such as cancer.

Your body “talks” in more ways than one. Your cells communicate with each other, enabling your different parts to function as one team. However, there are still many mysteries surrounding this process. Extracellular vesicles (EVs), small particles released by cells, were previously thought to be useless waste. However, in recent decades they have been dramatically relabeled as very important particles (VIPs), due to their association with various diseases, including cancer, neurodegenerative diseases and age-related diseases.

Small EVs have been found to play a key role in cell-to-cell communication. Depending on what “cargo” they carry from their host cell (which can include RNA, proteins and lipids), sEVs can help maintain normal tissue functions or can further the spread of diseases. Because of this, researchers are interested in how sEVs form and are released. However, separating sEVs from other molecules and identifying the factors which lead to their release is both difficult and time-consuming with conventional methods. So, a team in Japan has developed a new technique.

Nov 26, 2024

Inside the Laboratory for Extraordinary Microbes

Posted by in categories: biotech/medical, genetics

Zoom

An exciting Focused Research Organization (FRO): is systematically developing tools for working with non-model microorganisms.


As we walked, Lee told me that’s efforts to make “extraordinary” organisms accessible almost always follow the same basic steps. First, the team orders a microbe from ATCC, a non-profit group that has been storing and mailing microbes to researchers since 1925. The ATCC catalog includes more than 14,000 bacterial strains, the vast majority of which gather dust and are rarely ordered by researchers.

After receiving a microbe in the mail, sequences it. Mutations can creep into strains over time, and even a seemingly minor alteration—a single base swapped here or there—can change how cells grow and respond to their environment.

Continue reading “Inside the Laboratory for Extraordinary Microbes” »

Nov 26, 2024

Ed Boyden: “Synthetic Neurobiology: Optically Engineering the Brain to Augment Its Function”

Posted by in categories: computing, engineering, genetics, neuroscience, singularity

Ed Boyden is a professor at the MIT Media Lab working on the most advanced brain-computer interfacing technology currently available, optogenetics. At Singularity Summit 2009.

Nov 25, 2024

Revolutionizing Epigenetics: A New Era Of DNA Methylation Sequencing

Posted by in categories: biotech/medical, chemistry, genetics

Zoom

Oxford Nanopore Technologies and Wasatch BioLabs have joined forces to develop a groundbreaking direct whole-methylome sequencing (dWMS) product. This collaboration addresses the limitations of traditional methylation sequencing methods, such as bisulfite sequencing and methylation microarrays.

By leveraging Oxford Nanopore’s advanced sequencing technology and Wasatch BioLabs’ proprietary methylation assays, the partners aim to offer a more comprehensive and accurate approach to studying epigenetic modifications. dWMS eliminates the need for harsh chemical treatments and PCR amplification, reducing biases and improving genome-wide coverage.

This innovative technology has the potential to revolutionize epigenetic research, providing valuable insights into the role of methylation in various biological processes and diseases. The collaboration between these two companies is poised to drive significant advancements in genomics and precision medicine.

Nov 25, 2024

Bright Nights, Dark Days, And Low Greenspace Exposure Are Associated With Poor Health

Posted by in categories: biotech/medical, genetics, life extension

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get my labs): https://www.ultalabtests.com/partners/michaellustgarten.

Continue reading “Bright Nights, Dark Days, And Low Greenspace Exposure Are Associated With Poor Health” »

Page 7 of 515First4567891011Last