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Archive for the ‘genetics’ category: Page 8

May 17, 2019

Dr. Aubrey de Grey, Co-Founder and CSO of the SENS Research Foundation — ideaXme — Ira Pastor

Posted by in categories: aging, bioengineering, bioprinting, biotech/medical, business, cryonics, futurism, genetics, health, life extension

May 17, 2019

Scientists Created This Organism’s DNA From Scratch

Posted by in categories: biotech/medical, genetics

For the first time, scientists have created life with genetic code that was developed from scratch.

A University of Cambridge team created living, reproducing E. coli bacteria with DNA coded entirely by humans, according to The New York Times. The new bacteria look a little wonky, but they behave more or less the same as natural E. coli. Learning to rebuild genomes from scratch could teach scientists how DNA originally came to be — and how we can manipulate it to create new life.

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May 17, 2019

Natural compound found in broccoli reawakens the function of potent tumor suppressor

Posted by in categories: biotech/medical, food, genetics

Your mother was right: Broccoli is good for you. Long associated with decreased risk of cancer, broccoli and other cruciferous vegetables—the family of plants that also includes cauliflower, cabbage, collard greens, Brussels sprouts and kale—contain a molecule that inactivates a gene known to play a role in a variety of common human cancers. In a new paper published today in Science, researchers, led by Pier Paolo Pandolfi, MD, Ph.D., Director of the Cancer Center and Cancer Research Institute at Beth Israel Deaconess Medical Center, demonstrate that targeting the gene, known as WWP1, with the ingredient found in broccoli suppressed tumor growth in cancer-prone lab animals.

“We found a new important player that drives a pathway critical to the development of , an enzyme that can be inhibited with a natural compound found in broccoli and other ,” said Pandolfi. “This pathway emerges not only as a regulator for control, but also as an Achilles’ heel we can target with therapeutic options.”

A well-known and potent suppressive gene, PTEN is one of the most frequently mutated, deleted, down-regulated or silenced in human cancers. Certain inherited PTEN mutations can cause syndromes characterized by cancer susceptibility and developmental defects. But because complete loss of the gene triggers an irreversible and potent failsafe mechanism that halts proliferation of cancer cells, both copies of the gene (humans have two copies of each gene; one from each parent) are rarely affected. Instead, exhibit lower levels of PTEN, raising the question whether restoring PTEN activity to normal levels in the cancer setting can unleash the gene’s tumor suppressive activity.

Continue reading “Natural compound found in broccoli reawakens the function of potent tumor suppressor” »

May 16, 2019

Russia joins in global gene-editing bonanza

Posted by in category: genetics

Alexey Kochetov, director of the Siberian Branch of the Russian Academy of Sciences (RAS) Institute of Cytology and Genetics in Novosibirsk, welcomed the research programme, noting that genetics in Russia has been “chronically underfinanced” for decades. Funding for science plummeted in the 1990s following the break-up of the Soviet Union, and Russia still lags behind other major powers: in 2017, it spent 1.11% of its gross domestic product on research, compared with 2.13% in China and 2.79% in the United States.


A US$1.7-billion programme aims to develop 30 gene-edited plant and animal varieties in the next decade. A US$1.7-billion programme aims to develop 30 gene-edited plant and animal varieties in the next decade.

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May 15, 2019

Potential drug targets for ALS and FTD identified in two studies

Posted by in categories: biotech/medical, genetics, neuroscience

A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature Neuroscience and PNAS, provide a new layer of detail about how hexanucleotide repeat expansions in the C9ORF72 gene, the most common genetic mutation responsible for both ALS and FTD, causes neuron cell death. The Nature Neuroscience study also describes a new mouse model that more closely mimics the gradual build-up of toxins in patients with the diseases.

“Understanding how these mutations lead to motor neuron damage is important to the development of new treatment approaches,” said Dr. Gao, the Governor Paul Cellucci Chair in Neuroscience Research and professor of neurology. “We know that this mutation can cause these diseases. These studies show that both and DNA repair pathways are disrupted when the mutated gene is present in cells. That makes them potentially druggable targets.”

In ALS, a progressive, neurodegenerative disorder affecting the motor neurons in the central nervous system, the C9ORF72 gene accounts for 40 percent of inherited forms of the disease and 6 percent of sporadic cases. As motor neurons die, the brain’s ability to send signals to the body’s muscles is compromised. This leads to loss of voluntary muscle movement, paralysis and eventually death from respiratory failure.

Continue reading “Potential drug targets for ALS and FTD identified in two studies” »

May 15, 2019

Blood biopsy: New technique enables detailed genetic analysis of cancer cells

Posted by in categories: biotech/medical, genetics

A new way to cleanly separate out cancer cells from a blood sample enables comprehensive genetic profiling of the cancer cells, which could help doctors target tumors and monitor treatments more effectively.

It is a dramatic improvement over current approaches because it also encompasses the variation among cells within a single patient.

“This could be a whole different ball game,” said Max Wicha, the Madeline and Sidney Forbes Professor of Oncology at the University of Michigan and senior physician on the study in Nature Communications.

Continue reading “Blood biopsy: New technique enables detailed genetic analysis of cancer cells” »

May 15, 2019

Dr. Matthew Roberts, CSO and SVP Innovation, Chromadex — ideaXme — Ira Pastor

Posted by in categories: aging, biotech/medical, business, chemistry, DNA, finance, genetics, health, life extension, transhumanism

May 15, 2019

Two infants treated with universal immune cells have their cancer vanish

Posted by in categories: biotech/medical, genetics

In a medical first, the children were treated with genetically engineered T-cells from another person.

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May 15, 2019

Gene editing: will it make rich people genetically superior?

Posted by in categories: bioengineering, biotech/medical, genetics

There’s no doubt that genetic therapy won’t be cheap.

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May 15, 2019

Gene Hackers: The Young Biotech Entrepreneurs Looking To Make Billions

Posted by in categories: biotech/medical, genetics

Entrepreneurs are taking genetic-editing technology from the lab to the clinic with grand ambitions. But who owns the patents?

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