Thousands of patients will benefit from a new cancer jab for more than a dozen types of the disease, with the NHS the first in Europe to offer the new injection. The health service is rolling out an injectable form of immunotherapy, nivolumab, which means patients can receive their fortnightly or monthly treatment in 5 […]
Urban rats spread a deadly bacteria as they migrate within cities that can be the source of a potentially life-threatening disease in humans, according to a six-year study by Tufts University researchers and their collaborators that also discovered a novel technique for testing rat kidneys.
Leptospirosis is a disease caused by a type of bacteria often found in rats. It’s spread through their urine into soil, water, or elsewhere in the environment, where it becomes a source of infection and contamination for humans, dogs, and other species. While it’s prevalent worldwide, it’s more common in tropical regions, though a changing climate means it could become more common in colder regions as they warm.
In Boston, leptospirosis persists in local rat populations, and different strains of the bacteria move around the city as groups of rats migrate, according to a new study by Marieke Rosenbaum, M.P.H., D.V.M., assistant professor in the Department of Infectious Disease and Global Health at Cummings School of Veterinary Medicine at Tufts University, along with co-authors at Northern Arizona University (NAU), the United States Department of Agriculture (USDA), and the Centers for Disease Control and Prevention (CDC). In addition, their genetic analysis of a 2018 human leptospirosis case in Boston strongly suggests a link to rats as the source.
Managing complex medication schedules could soon become as simple as taking a single capsule each day. Engineers at the University of California San Diego have developed a capsule that can be packed with multiple medications and release them at designated times throughout the day.
The advance, published in Matter, could help improve medication adherence and health outcomes by eliminating the need for patients to remember taking multiple drugs or doses at various times each day. It could potentially reduce the risk of missed doses or accidental overdoses.
“We want to simplify medication management with a single capsule that is smart enough to deliver the right drug at the right dose at the right time,” said study first author Amal Abbas, who recently earned her Ph.D. in chemical engineering at the UC San Diego Jacobs School of Engineering. She spearheaded this work with Joseph Wang, a professor in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering at UC San Diego.
New research from the University of Bristol has uncovered striking links between immune system proteins and neuropsychiatric conditions, including schizophrenia, depression, and Alzheimer’s disease. By analyzing large genetic datasets using Mendelian randomisation, scientists identified 29 immune-related proteins potentially playing a causal role in these disorders.
The findings suggest that mental health conditions may not be isolated to the brain but involve the entire body, potentially reshaping future treatment strategies. This video explores how inflammation and immune pathways could be the next frontier in neuropsychiatric care.
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Flourishing is more than just being happy, and a new global study finds some countries are doing better than others when it comes to overall well-being.
Take it from researchers at Baylor and Harvard universities, who unveiled a study Wednesday that included more than 207,000 people from 22 countries and Hong Kong. The study is published in the journal Nature Mental Health.
Their Global Fluorishing Study looked at six areas of well-being: happiness, health, meaning, character, relationships and financial security, CNN reported.
Researchers at Korea’s Daegu Gyeongbuk Institute of Science and Technology (DGIST) have developed a porous laser-induced graphene (LIG) sensor array that functions as a “next-generation AI electronic nose” capable of distinguishing scents like the human olfactory system does and analyzing them using artificial intelligence.
This technology converts scent molecules into electrical signals and trains AI models on their unique patterns. It holds great promise for applications in personalized health care, the cosmetics industry, and environmental monitoring.
While conventional electronic noses (e-noses) have already been developed and used in areas such as food safety and gas detection in industrial settings, they struggle to distinguish subtle differences between similar smells or analyze complex scent compositions. For instance, distinguishing among floral perfumes with similar notes or detecting the faint odor of fruit approaching spoilage remains challenging for current systems. This gap has driven demand for next-generation e-nose technologies with greater precision, sensitivity, and adaptability.
The potential role of vitamin D in preventing and treating colorectal cancer (CRC) has attracted growing research interest – especially as CRC rates are rising, particularly among younger adults. This isn’t a new area of study. Low vitamin D levels have long been linked to a higher risk of developing colorectal cancer.
One large study involving over 12,000 participants found that people with low blood levels of vitamin D had a 31 per cent greater risk of developing CRC compared to those with higher levels. Similarly, another study reported a 25 per cent lower CRC risk among individuals with high dietary vitamin D intake.
Data from the Nurses’ Health Study – a long-term investigation of American nurses – showed that women with the highest vitamin D intake had a 58 per cent lower risk of developing colorectal cancer compared to those with the lowest intake.
The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by Radboud University Medical Center shows how this process works. Lactate, a product of scaled-up energy production, appears to play a leading role.
The immune system protects people in two ways. Innate immunity protects us from birth against many bacteria and viruses, while adaptive immunity builds protection against individual pathogens after a prior infection. The adaptive immune system is aided by vaccines that protect us against new pathogens without having to go through an infection. In this way, vaccines contribute greatly to our health.
Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers. The results, recently published in The Lancet Oncology, show encouraging signs of the safety and potential effectiveness of the treatment.
“Despite many advances in understanding the genomic drivers and other factors causing cancer, with few exceptions, stage IV colorectal cancer remains a largely incurable disease,” said Emil Lou, MD, Ph.D., a gastrointestinal oncologist with the University of Minnesota Medical School, Masonic Cancer Center and M Health Fairview, and clinical principal investigator for the trial. “This trial brings a new approach from our research labs into the clinic and shows potential for improving outcomes in patients with late-stage disease.”
In the study, researchers used CRISPR/Cas9 gene-editing to modify a type of immune cell called tumor-infiltrating lymphocytes (TILs). By deactivating a gene called CISH, the researchers found that modified TILs were better able to recognize and attack cancer cells.