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New blood test detects key indicator of Parkinson’s disease

A new blood-based diagnostic test could be a major advancement for the treatment of Parkinson’s, a disease that afflicts 10 million people worldwide and is the second-most common neurodegenerative disease after Alzheimer’s.

Building on the knowledge that mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s a team of researchers, led by neuroscientists at Duke Health, have developed an assay that enables the accurate, real-time quantification of mitochondrial DNA damage in a scalable platform [1]. The results of the study, which received support in part from The Michael J Fox Foundation for Parkinson’s Research, have been published in the journal Science Translational Medicine.

“Currently, Parkinson’s disease is diagnosed largely based on clinical symptoms after significant neurological damage has already occurred,” said senior author Laurie Sanders, PhD, an associate professor in Duke School of Medicine’s departments of Neurology and Pathology and member of the Duke Center for Neurodegeneration and Neurotherapeutics.

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The study reveals a strong association between gut microbial carbohydrate metabolism and insulin resistance, pointing to gut microbes as a key player in metabolic syndrome and type 2 diabetes. Targeting these microbial activities could offer a new therapeutic pathway for improving insulin resistance and overall metabolic health.

The potential for artificial intelligence in healthcare

The complexity and rise of data in healthcare means that artificial intelligence (AI) will increasingly be applied within the field. Several types of AI are already being employed by payers and providers of care, and life sciences companies. The key categories of applications involve diagnosis and treatment recommendations, patient engagement and adherence, and administrative activities. Although there are many instances in which AI can perform healthcare tasks as well or better than humans, implementation factors will prevent large-scale automation of healthcare professional jobs for a considerable period. Ethical issues in the application of AI to healthcare are also discussed.

KEYWORDS: Artificial intelligence, clinical decision support, electronic health record systems.

Artificial intelligence (AI) and related technologies are increasingly prevalent in business and society, and are beginning to be applied to healthcare. These technologies have the potential to transform many aspects of patient care, as well as administrative processes within provider, payer and pharmaceutical organisations.

New Covid vaccines from Pfizer, Moderna and Novavax will likely protect against Eris variant

The drugmakers designed their updated vaccines to target the omicron subvariant XBB.1.5, which is slowly declining nationwide. But health experts and initial data suggest that the new shots will still be effective against Eris, or EG.5, and other widely circulating variants – all of which are descendants of omicron.

“I think that these vaccines will provide very substantial protection against EG.5. Maybe just a little bit of loss, but it’s nothing that I’m very concerned about,” Dr. Mark Mulligan, director of the NYU Langone Vaccine Center, told CNBC. “It looks like we’re going to be OK.”

All three companies are still waiting for the Food and Drug Administration to approve their vaccines, meaning those jabs won’t be available to the public for a month or so. The Centers for Disease Control and Prevention also has to decide which Americans should get the shots and how often.

Did Tryptophan And/Or Serine Mess Up Blood Biomarkers? (Blood Test #5 in 2023 Analysis)

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Biological clocks: How does the body know that time goes by?

In April of this year, Spanish athlete Beatriz Flamini emerged into the light after a 500-day stay in a cave. Her descent underground is probably the longest undertaken by a long stretch. Flamini says she lost all sense of time on the 65th day. But can she really be sure it was the 65th day? By way of comparison, in 1962 France’s Michel Siffre surfaced from the Scarasson chasm in Italy after spending what he thought was 33 days there. In fact, he spent 58 days underground.

How can isolated human beings keep regular track of time, even when they’re disconnected from their surrounding environment? Quite simply, because biological rhythms are at the heart of life, regulating it all the way from the up to that of the entire body. These include not only our sleep/, but also body temperature, hormones, metabolism and the cardiovascular system, to name but a few.

And these rhythms have many repercussions, not least in terms of public health. Indeed, a number of diseases are episodic—for example, asthma is more severe at night, while cardiovascular accidents are more frequent in the morning. Another example is shift work, which disconnects people from their environment. It may be associated with an increased risk of cancers in workers, prompting the WHO to label it as a probable carcinogen.

Scientists develop finger sweat test to detect antipsychotic drugs in patients

Antipsychotic drugs treat incredibly vulnerable patients. Maintaining a treatment regimen is difficult for many patients, but not taking the medication is associated with a higher risk of poor health outcomes. These drugs are also very powerful with strong side effects, and blood tests are often used to calibrate a patient’s dosage and confirm that they are taking the recommended dose.

However, blood tests are invasive and potentially uncomfortable. Scientists have now discovered a way to test the levels of common in the sweat from patients’ fingerprints, offering a quicker, more comfortable, and more convenient alternative to blood draws for patient monitoring.

“Our test offers patients a quick and dignified way of showing commitment to antipsychotic treatment,” said Katherine Longman of the University of Surrey, first author of the study in Frontiers in Chemistry. “This non-invasive approach can also be adapted to fit other therapeutic regimes.”

Eye drop recall grows after FDA warning, reports of ‘adverse events’

(WJW) – A nationwide recall of tainted eye drops is growing after bacterial and fungal contamination were found in sample tests, according to the Food and Drug Administration (FDA).

Dr. Berne’s Whole Health Products is now voluntarily recalling all lots of the company’s MSM Drops 5% Solution, 15% Solution, Organic Castor Oil Eye Drops and MSM Mist 15% Solution.

IBM makes major leap in quantum computing error-detection

Quantum computing is on the verge of catapulting the digital revolution to new heights.

Turbocharged processing holds the promise of instantaneously diagnosing health ailments and providing rapid development of new medicines; greatly speeding up response time in AI systems for such time-sensitive operations as autonomous driving and space travel; optimizing traffic control in congested cities; helping aircraft better navigate extreme turbulence; speeding up weather forecasting that better prepares localities facing potential disaster, and optimizing supply chain systems for more efficient delivery times and cost savings.

But we’re not there yet. One of the greatest obstacles facing quantum operations is error-correction.

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