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Some interesting new information on how humans use energy and why exercise is not necessarily useful for losing weight (though it can help prevent gaining weight in the first place and of course is good for health).

I’m still curious why I accidentally lost about 30 pounds without intending to while I was eating probably twice as much as normal when I spent three months at the South Pole (2007−08). Did the cold increase my brown fat and my metabolism? Did it have something to do with unpolluted air and water? Was it a difference in the food, most of which was from New Zealand? Was it the high altitude (equivalent to about 10,500 feet at the equator)? Did the roughly 30 pounds of extra clothing I wore every day somehow trigger weight loss to “maintain” my previous weight? Something else?

As this example shows, there is still a great deal we can learn about these questions which are crucial to maintaining human health.


The work of evolutionary anthropologist Herman Pontzer shows why humans are the fattest, highest energy apes.

Scientists have uncovered a set of neurons in fruit flies that shut down in cold temperatures and slow reproduction, a system conserved in many insects, including mosquitoes, which could provide a target for pest control.

Their study, published Feb. 16 in the journal Current Biology, takes a step toward understanding how a fly’s brain contributes to sensing the cold and limiting . Insects and animals, including many mammals, curb reproduction in the winter to protect their newborns from being exposed to harsh winter conditions.

The study has and agricultural implications, as tapping into environmentally-dependent mechanisms that influence reproduction in and crop pests may offer new control strategies. Mosquitoes act as reservoirs for the malaria-causing Plasmodium falciparum parasite, which spend the winter inside them.

Urban air pollution exposure is an ongoing critical challenge for humanity today because the majority of us live in cities. A just-published study in The Lancet Planetary Health reports that 2.5 billion live in urban areas where particulate matter levels exceed World Health Organization (WHO) safety guidelines causing more than 1.8 million attributed deaths annually. The study reports that “the global health burden of ambient fine particulate matter is increasing annually” and is associated with mortality from cardiovascular, respiratory, and lung diseases including cancer. And in terms of chronic diseases, particulate matter in the air contributes to asthma, bronchitis and emphysema, and seen as the leading environmental risk humans face today.

What is particulate matter? The Canadian government defines it as airborne particles that can be solid or liquid. Particulate matter comes from natural and human sources. The natural ones can be seen when volcanoes erupt spewing ash and other aerosols high into the atmosphere. But far more dangerous because of the sheer volume, is human-produced particulate matter coming from smokestacks, tailpipes, power plants, recently tilled fields, tires running across asphalt and concrete roads, and other human activities that release fine particles into the wind. The lighter and smaller the particle, the greater the threat. That’s because fine particulate matter is easier to inhale. It’s also easier to enter the pores of leaves in plants, and easier as liquid aerosols to bind to our buildings and bridges and other infrastructure where its acidic nature causes corrosion.

A particle of 2.5 micrometres (equivalent to 0.00009843 inches) or less is a public health threat. The U.S. Environmental Protection Agency tracks aerosol pollution at this size and on its site notes that particulate matter smaller than 2.5 micrometres has been declining for two decades. The Lancet study contradicts this finding noting that globally levels of airborne particulate matter have changed very little in twenty years. And where’s the greatest rise? In the cities of Southeast Asia.

Bright indoor lighting during daytime.


According to a new study published in Diabetologia, Insulin-resistant volunteers’ postprandial substrate processing, energy expenditure, and thermoregulation are all affected by the indoor light environment in a time-dependent manner. Further Optimization of indoor lighting to a brighter during daytime hours and dimmer in the evening may provide cardiometabolic benefits.

Artificial light is available 24 hours a day in today’s civilization, and most individuals are exposed to electrical light and light-emitting screens during the dark part of the natural light/dark cycle. Suboptimal lighting has been linked to negative metabolic impacts, and changing indoor lighting to more closely mirror the natural light/dark cycle has the potential to improve metabolic health.

This study was conducted by Jan-Frieder Harmsen and team with the objective to evaluate metabolic reactions in persons at risk of developing metabolic disorders to lighting conditions that resembled the natural light/dark cycle against poor illumination.

Measuring Human Biology in Action, To Cure, Prevent Or Manage All Diseases — Dr. Stephani Otte, Ph.D., Science Program Officer, Imaging, Chan Zuckerberg Initiative.


Dr. Stephani Otte, Ph.D is Science Program Officer, Imaging, at the Chan Zuckerberg Initiative (https://chanzuckerberg.com/), who leads the organization’s Imaging program and is focused on the creation, dissemination, optimization, and standardization of transformative imaging technologies.

Prior to CZI, Dr. Otte was Director of Science at a neuro-technology / microscopy company, Inscopix, involved in accelerating brain science and innovating mini-scope microscope solutions for real-time mapping of the human brain and it’s circuits.

The AI revolution is here. Machine learning (ML) and artificial intelligence are used in virtually every industry today to revolutionize everything from reducing food waste to achieving better health outcomes. In all, IDC forecasts that global enterprise spending on AI will eclipse $204 billion by 2025.

Unfortunately, investments in needed infrastructure may not be keeping pace. Many enterprises are shipping AI blind or relying on outdated model monitoring approaches to catch issues with models in production.

In order to understand the scope of the problem and provide insights on potential solutions, Arize AI recently conducted a survey of 945 data scientists, engineers, executives, and others in the industry. The results speak to a distinct need for better tools to quickly visualize where and why problems are emerging and enable faster root cause analysis when models fail.

David M’zee was 22 when an injury damaged his spine, leaving him paralysed 12 years ago.

In 2017, an electrical implant to his spine enabled him to stand and walk slowly by boosting the nerve signals to his legs.

He uses the device for short periods to exercise his muscles and practise walking, and says that even when it’s not turned on, it’s brought such an improvement to his health that he’s been able to have a child.

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By Helen O’Shea

On a windy, bright day in Lemoore, California another 250 megawatts of clean power was added to California’s energy mix with the dedication of the Aquamarine Solar Project. There are many new solar projects coming online across the country these days, but the Aquamarine project is notable for its innovative development model — it’s part of a 20,000-acre master-planned solar park on fallowed and salt-contaminated agricultural lands in the Westlands Water District in California’s Central Valley.

Disturbed lands farmed for years with no residual habitat value are the perfect place to locate utility-scale solar projects. In 2016 these lands, among many others, were identified as suitable for development by a diverse group of stakeholders through the San Joaquin Valley Least Conflict Solar Planning exercise.