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Many potential pathways to future pandemic influenza

Influenza viruses are believed to have sparked at least 14 human pandemics in the past 500 years; the most devastating of which began in 1918. Yet, despite intense study and considerable advances in public health, virus surveillance and virology, there is no simple answer to this pressing question: when and how will the next flu pandemic arise?

NIAID scientists including Jeffery K. Taubenberger, M.D., Ph.D., consider the many potential pathways to future influenza pandemics in a new viewpoints essay in Science Translational Medicine. There are no hard and fast ‘rules’ specifying, for example, what characteristics a given avian influenza virus must possess to allow it to efficiently infect… More.


Influenza pandemics have emerged for centuries but still cannot be accurately predicted.

Month after pig heart transplant, Maryland man pushing through “tough” physical therapy

It’s been a month since a Maryland man became the second person to receive a transplanted heart from a pig — and hospital video released Friday shows he’s working hard to recover.

Lawrence Faucette was dying from heart failure and ineligible for a traditional heart transplant when doctors at the University of Maryland School of Medicine offered the highly experimental surgery.

In the first glimpse of Faucette provided since the Sept. 20 transplant, hospital video shows physical therapist Chris Wells urging him to push through a pedaling exercise to regain his strength.

Driving companywide efficiencies with AI

Autonomous shopping carts that follow grocery store customers and robots that pick ripe cucumbers faster than humans may grab headlines, but the most compelling applications of AI and ML technology are behind the scenes. Increasingly, organizations are finding substantial efficiency gains by applying AI-and ML-powered tools to back-office procedures such as document processing, data entry, employee onboarding, and workflow automation.

The power of automation to augment productivity in the back office has been clear for decades, but the recent emergence of advanced AI and ML tools offers a step change in what automation can accomplish, including in highly regulated industries such as health care.

Novel Immune Cell Types and Interactions within Adipose Tissue Revealed

Researchers are attempting to uncover the basics of how fat tissue is structured and, specifically, inflammation associated with obesity, in the hopes of unlocking the connection between the accumulation of fat and poor health outcomes. Now, a new study by researchers at the University of Michigan revealed previously unrecognized immune cell types and interactions within adipose tissue using single-cell analysis of gene expression combined with spatial transcriptomics.

The findings are published in JCI Insight in an article titled, “A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity.”

“Adipose tissue macrophage (ATM) infiltration is associated with adipose tissue dysfunction and insulin resistance in mice and humans,” wrote the researchers. “Recent single-cell data highlight increased ATM heterogeneity in obesity but do not provide a spatial context for ATM phenotype dynamics. We integrated single-cell RNA-Seq, spatial transcriptomics, and imaging of murine adipose tissue in a time course study of diet-induced obesity. Overall, proinflammatory immune cells were predominant in early obesity, whereas nonresident antiinflammatory ATMs predominated in chronic obesity.”

Suzanne Somers’ family reveals her cause of death: What to know about her health

Actor Suzanne Somers has died at the age of 76 after being diagnosed with breast cancer more than two decades ago, which ultimately was her cause of death.

Somers was best known for her roles in the hit sitcoms “Three’s Company” and “Step by Step,” and later in life for her health and fitness business ventures.

Somers died “peacefully at home” surrounded by her family on Oct. 15, one day before her 77th birthday, according to a statement to NBC News from Somers’ publicist on behalf of her family.

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