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Category: health – Page 197

Hear from Nobel laureate Jennifer Doudna on the four ways that CRISPR gene editing technologies will revolutionize healthcare.

In her 31 March talk at the Frontiers Forum, Prof Jennifer Doudna outlined how CRISPR-based therapies are already transforming the lives of patients with previously limited treatment options. She also gave her vision for how her serendipitous discovery will revolutionize healthcare for us all. The session was attended by over 9,200 representatives from science, policy and business across the world.

Jennifer’s keynote talk was followed by a discussion with global experts on access and ethical considerations:
• Prof Andrea Crisanti, Imperial College London.
• Prof Françoise Baylis, Dalhousie University.
• Dr Soumya Swaminathan, Chief Scientist, World Health Organization.

2022 marks the 10th anniversary of Jennifer’s groundbreaking development of CRISPR-Cas9 as a genome-engineering technology, with collaborator Prof Emmanuelle Charpentier. The two earned the 2020 Nobel Prize in Chemistry for their work, which has forever changed the course of human and agricultural genomics research. Jennifer Doudna is the Li Ka Shing Chancellor’s Chair and a Professor in the Departments of Chemistry and of Molecular and Cell Biology at the University of California, Berkeley, and Founder of the Innovative Genomics Institute.

The Frontiers Forum showcases science-led solutions for healthy lives on a healthy planet. Watch previous sessions at https://forum.frontiersin.org.

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Assistance robots are typically mobile robots designed to assist humans in malls, airports, health care facilities, home environments and various other settings. Among other things, these robots could help users to find their way around unknown environments, for instance guiding them to a specific location or sharing important information with them.

While the capabilities of assistance robots have improved significantly over the past decade, the systems that have so far been implemented in real-world environments are not yet capable of following or guiding humans efficiently within crowded spaces. In fact, training robots to track a specific user while navigating a dynamic environment characterized by many randomly moving “obstacles” is far from a simple task.

Researchers at the Berlin Institute of Technology have recently introduced a new model based on deep reinforcement learning that could allow to guide a specific user to a desired location or follow him/her around while carrying their belongings, all within a crowded environment. This model, introduced in a paper pre-published on arXiv, could help to significantly enhance the capabilities of robots in malls, airports and other public places.

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Cosmologist, noted author, Astronomer Royal and recipient of the 2015 Nierenberg Prize for Science in the Public Interest Lord Martin Rees delivers a thought-provoking and insightful perspective on the challenges humanity faces in the future beyond 2050. [3/2016] [Show ID: 30476]

Frontiers of Knowledge.
(https://www.uctv.tv/frontiers-of-knowledge)

Explore More Science & Technology on UCTV
(https://www.uctv.tv/science)
Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells.

UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California — teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv)

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Mobile robots are now being introduced into a wide variety of real-world settings, including public spaces, home environments, health care facilities and offices. Many of these robots are specifically designed to interact and collaborate with humans, helping them to complete hands-on physical tasks.

To improve the performance of on interactive and manual tasks, roboticists will need to ensure that they can effectively sense stimuli in their environment. In recent years, many engineers and material scientists have thus been trying to develop systems that can artificially replicate biological sensory processes.

Researchers at Scuola Superiore Sant’Anna, Ca’ Foscari University of Venice, Sapienza University of Rome and other institutes in Italy have recently used an artificial skin and a that could be used to improve the tactile capabilities of both existing and newly developed robots to replicate the function of the so-called Ruffini receptors. Their approach, introduced in a paper published in Nature Machine Intelligence, replicates the function of a class of cells located on the human superficial dermis (i.e., subcutaneous skin tissue), known as Ruffini receptors.

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Research led by Suresh Alahari, Ph.D., Professor of Biochemistry at LSU Health New Orleans schools of Medicine and Graduate Studies, suggests a combination of drugs already approved by the FDA for other cancers may be effective in treating chemo-resistant triple-negative breast cancer. The results are published in Molecular Cancer.

Triple-negative breast cancer (TNBC) tumors lack estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). A subtype representing 12–55% of tumors has androgen receptors (AR). Since stimulate tumor cell progression in estrogen receptor-negative breast cancers, they have become a target of triple-negative breast cancer therapy. As well, since a substantial number of patients with triple-negative breast cancer develop resistance to paclitaxel, the FDA-approved chemotherapeutic agent for triple-negative breast cancer, new therapeutic approaches are needed.

Working in a mouse model and tissue from patients with triple-negative breast cancer, the research team screened 133 FDA-approved drugs that have a therapeutic effect against androgen receptor cells. They found that ceritinib, an FDA-approved drug for lung cancers, efficiently inhibited the growth of androgen receptor triple-negative breast cancer cells. To improve the response, they also selected enzalutamide, an FDA-approved androgen receptor antagonist for prostate cancer treatment.

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Environmental sensors are a step closer to simultaneously sniffing out multiple gases that could indicate disease or pollution, thanks to a Penn State collaboration. Huanyu “Larry” Cheng, assistant professor of engineering science and mechanics in the College of Engineering, and Lauren Zarzar, assistant professor of chemistry in Eberly College of Science, and their teams combined laser writing and responsive sensor technologies to fabricate the first highly customizable microscale gas sensing devices.

They published their technique this month in ACS Applied Materials & Interfaces.

“The detection of gases is of critical importance to various fields, including pollution monitoring, public safety assurance and personal health care,” Cheng said. “To fill these needs, sensing devices must be small, lightweight, inexpensive and easy to use and apply to various environments and substrates, such as clothing or piping.”

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Saúl Morales RodriguézAuthor

The success of deep learning depends heavily on the availability of large datasets, but in robotic manipulation there are many learning problems for which such datasets do not exist. Collecting these datasets is time-consuming and expensive, and therefore learning from small datasets is an important open problem. Within computer vision, a common approach to a lack of data is data augmentation. Data augmentation is the process of creating additional training examples by modifying existing ones. However, because the types of tasks and data differ, the methods used in computer vision cannot be easily adapted to manipulation. Therefore, we propose a data augmentation method for robotic manipulation. We argue that augmentations should be valid, relevant, and diverse.

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Probiotics show a new to battle cancer and other diseases keeping the host body healthy with its anti inflammation abilities.

Gut microbiota is widely considered to be one of the most important components to maintain balanced homeostasis. Looking forward, probiotic bacteria have been shown to play a significant role in immunomodulation and display antitumour properties. Bacterial strains could be responsible for detection and degradation of potential carcinogens and production of short-chain fatty acids, which affect cell death and proliferation and are known as signaling molecules in the immune system. Lactic acid bacteria present in the gut has been shown to have a role in regression of carcinogenesis due to their influence on immunomodulation, which can stand as a proof of interaction between bacterial metabolites and immune and epithelial cells. Probiotic bacteria have the ability to both increase and decrease the production of anti-inflammatory cytokines which play an important role in prevention of carcinogenesis. They are also capable of activating phagocytes in order to eliminate early-stage cancer cells. Application of heat-killed probiotic bacteria coupled with radiation had a positive influence on enhancing immunological recognition of cancer cells. In the absence of active microbiota, murine immunity to carcinogens has been decreased. There are numerous cohort studies showing the correlation between ingestion of dairy products and the risk of colon and colorectal cancer. An idea of using probiotic bacteria as vectors to administer drugs has emerged lately as several papers presenting successful results have been revealed. Within the next few years, probiotic bacteria as well as gut microbiota are likely to become an important component in cancer prevention and treatment.

Cancer is considered as one of the most significant causes of death. The treatment of tumors has received much attention in the last years; however, the number of people suffering neoplastic syndrome is still increasing. Thus, researchers are trying to face this process searching for innovative therapies and prophylaxis. Despite the fact that cancer risk indisputably depends on genetic factors, immunological condition of the organism plays a considerable role in it, that being closely associated with probiotic bacteria and commensal bacterial flora presented mainly in the digestive tract. Probiotic strains, inter alia Bifidobacterium, or Lactobacillus, widely present in commonly consumed fermented milk products, are known to have various beneficial effects on health. To date, there is a plethora of studies investigating the correlation between intestinal microbiota and carcinogenesis which have been evaluated in this article.

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Blood pressure is one of the most important indicators of heart health, but it’s tough to frequently and reliably measure outside of a clinical setting. For decades, cuff-based devices that constrict around the arm to give a reading have been the gold standard. But now, researchers at The University of Texas at Austin and Texas A&M University have developed an electronic tattoo that can be worn comfortably on the wrist for hours and deliver continuous blood pressure measurements at an accuracy level exceeding nearly all available options on the market today.

“Blood pressure is the most important vital sign you can measure, but the methods to do it outside of the clinic passively, without a cuff, are very limited,” said Deji Akinwande, a professor in the Department of Electrical and Computer Engineering at UT Austin and one of the co-leaders of the project, which is documented in a new paper published today in Nature Nanotechnology.

High blood pressure can lead to serious heart conditions if left untreated. It can be hard to capture with a traditional blood pressure check because that only measures a moment in time, a single data point.

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In a surprise finding, researchers have found that getting at least one flu shot makes it 40 percent less likely for people over the age of 65 to be diagnosed with Alzheimer’s disease, up to four years later.

While it’s still far too early to determine if there are any direct causal links between the common vaccine and neurological health outcomes like Alzheimer’s — in other words, we don’t know if it’s the flu vaccine itself or something else responsible for the results — the research is certainly an eyebrow-raising new development that could, potentially, point in the direction of easily accessible treatments.

In a peer-reviewed study in the Journal of Alzheimer’s Disease, researchers at UTHealth Houston compared the incidence rate of the disease in patients with and without at least one flu vaccination in a nationwide sample of US adults aged 65 and up, which included 935,887 vaccinated and 935,887 non-vaccinated individuals.

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