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Denver Department of Public Health and Environment issued the order Thursday, the day after investigators said they were denied full access to the facility.

Denver health officials have ordered the closure of a United States Postal Service distribution center that handles all mail for Colorado and Wyoming, saying the facility has multiple confirmed cases of the coronavirus among its employees.

A research study in mice by investigators at the University of Rochester Medical Center (URMC) suggests it would be possible to repair the brain cell damage caused by multiple sclerosis (MS). The research was published in the journal Cell Reports.

The research, led by Steve Goldman, professor of Neurology and Neuroscience at URMC and co-director of the Center for Translational Neuromedicine, manipulated embryonic and induced pluripotent stem cells to create glia, a type of brain cell. Glial progenitor cells, a subtype of these cells, eventually form the primary support cells of the brain, astrocytes and oligodendrocytes, which play essential roles in the health and signaling behavior of nerve cells.

MS is an autoimmune disorder where the body’s immune system attacks oligodendrocytes. Oligodendrocytes manufacture myelin, which makes the insulation that allows nerve cells to communicate with each other. As myelin decreases in MS, the signaling between nerve cells is interrupted, which causes the loss of function that leads to problems with sensation, motor function and cognitive problems.

The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host’s innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and disease, while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs. We highlight aspects of the current knowledge, challenges and limitations in achieving causal understanding of host immune-microbiome interactions, as well as their impact on immune-mediated diseases, and discuss how these insights may translate towards future development of microbiome-targeted therapeutic interventions.

Maryland reported its highest number of new COVID-19 cases on Tuesday—just four days after the state began easing public health restrictions aimed at thwarting the spread of disease.

Though state officials note that an increase in testing and a backlog of test results may partly explain the spike, the case counts overall suggest that disease transmission has not declined in the lead-up to re-opening—and transmission could very easily increase as residents begin venturing into public spaces more frequently.

Maryland’s outcome may hold lessons for other states attempting their own reopening. As of today, May 20, all 50 states have begun easing restrictions at some level, according to The Washington Post.

From testing drugs to developing vaccines, the close study of the immune system is key to improving real-world health outcomes. T-cells are integral to this research, as these white blood cells help tailor the body’s immune response to specific pathogens.

With lattice light-sheet microscopy (LLSM), scientists have been able to closely examine individual cells, such as T-cells, in 4D. But with limited data points, there wasn’t an effective way to analyze the LLSM data.

A new paper by researchers from the Pritzker School of Molecular Engineering (PME) at the University of Chicago, published May 20 in the journal Cell Systems, introduces a solution—a pipeline for lattice light-sheet microscopy multi-dimensional analyses (LaMDA).

After biomedical scientists demonstrated that they could make dangerous viruses like influenza even more dangerous, the National Institutes of Health (NIH) implemented a three-year moratorium on funding such research. But a couple of months ago, in December, the moratorium was lifted, and a tight set of rules were put in its place, such as a mandate for oversight panels.

The prospect of engineering a deadly pandemic virus in a laboratory suggests that only a fool would wish away government regulation entirely.

However, as a whole, regulation has done more harm than good in the arena of scientific innovation. The reason is that the sort of person who thinks like a bureaucratic regulator isn’t the sort of person who thinks like a scientist. The sad fact of the matter is that those most interested in the regulatory process tend to be motivated by politics and ideology rather than scientific inquiry and technological progress.

Apple’s AR glasses are supposedly called Apple Glass, a leaker revealed, and the product is set to be unveiled during the iPhone 12 launch event. The coronavirus health crisis might force Apple to postpone the reveal to the first quarter of next year.

The pandemic COVID-19 has spread to all over the world and greatly threatens safety and health of people. COVID-19 is highly infectious and with high mortality rate. As no effective antiviral treatment is currently available, new drugs are urgently needed. We employed transcriptional analysis to uncover potential antiviral drugs from natural products or FDA approved drugs. We found liquiritin significantly inhibit replication of SARS-CoV-2 in Vero E6 cells with EC₅₀ = 2.39 μM. Mechanistically, we found liquiritin exerts anti-viral function by mimicking type I interferon. Upregulated genes induced by liquiritin are enriched in GO categories including type I interferon signaling pathway, negative regulation of viral genome replication and etc. In toxicity experiment, no death was observed when treated at dose of 300 mg/kg for a week in ICR mice. All the organ indexes but liver and serum biochemical indexes were normal after treatment. Liquiritin is abundant in licorice tablet (~0.2% by mass), a traditional Chinese medicine. Together, we recommend liquiritin as a competitive candidate for treating COVID-19. We also expect liquiritin to have a broad and potent antiviral function to other viral pathogens, like HBV, HIV and etc.

The authors have declared no competing interest.