Lifeboat Foundation

The Alzheimer’s Hypothesis

Introduction

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Alzheimer’s disease is one of the biggest medical challenges of our time. About 30 million people worldwide are living with Alzheimer’s disease, and the numbers are predicted to increase to 100 million by 2050 if we do not find effective prevention or treatment strategies (1). Substantial evidence suggests that leading a healthy lifestyle, including regular exercise, may lower the risk of developing Alzheimer’s disease. However, the mechanisms through which exercise protects the brain and whether we could bottle these as a treatment remain controversial. On page 991 of this issue, Choi et al. (2) reveal that in a mouse model of Alzheimer’s disease, exercise improves memory through a combination of encouraging neurogenesis in the hippocampus and increasing the levels of brain-derived neurotrophic factor (BDNF), a growth factor that supports neuronal survival. Their findings suggest that agents that promote both BDNF signaling and neurogenesis might be effective in preventing or treating Alzheimer’s disease.

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More than a quarter (1.4 billion) of the world’s adult population were insufficiently active in 2016, putting them at greater risk of cardiovascular disease, type 2 diabetes, dementia, and some cancers, according to the first study to estimate global physical activity trends over time. The study was undertaken by researchers from the World Health Organization (WHO) and published in The Lancet Global Health journal.

Together, these estimates demonstrate that there has been little progress in improving physical activity levels between 2001 and 2016. The data show that if current trends continue, the 2025 global activity target of a 10% relative reduction in insufficient physical activity will not be met.

“Unlike other major global health risks, levels of insufficient physical activity are not falling worldwide, on average, and over a quarter of all adults are not reaching the recommended levels of physical activity for good health,” warns the study’s lead author, Dr. Regina Guthold of the WHO, Switzerland.

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In this Viewpoint, Geoffrey Hinton of Google’s Brain Team discusses the basics of neural networks: their underlying data structures, how they can be trained and combined to process complex health data sets, and future prospects for harnessing their unsupervised learning to clinical challenges.

The red tide that is choking Florida’s southwest coast is causing symptoms including coughs, headaches and shortness of breath, local doctors say.

Satellite images could help target public health interventions.

Today we have an interview with Sci-Hub creator, Alexandra Elbakyan who is committed to the free flow of scientific knowledge and is challenging the unfair journal system which charges outrageous fees to view scientific publications.

Hiding scientific knowledge behind paywalls

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Wealthy Singapore is hyper-connected and on a drive to digitise government records and essential services, including medical records which public hospitals and clinics can share via a centralised database.

But authorities have put the brakes on these plans while they investigate the cyberattack. A former judge will head a committee looking into the incident.

While the city state has some of the most advanced military weaponry in the region, the government says it fends off thousands of cyberattacks every day and has long warned of breaches by actors as varied as high-school students in their basements to nation states.

Continue reading “Singapore hit by ‘most serious’ cyberattack, resulting in theft of health data of 1.5 million people – including the prime minister” »