Lifeboat Foundation

Exercise is a good idea if you want to live long enough to see new technologies arrive that could change how we age.

A fair amount of interesting research on the topic of exercise and aging passes by every month. Most is not really worth commenting on here, other than to reinforce the point that there is a very, very large body of evidence to link regular exercise with improved long-term health and reduced mortality. Since I did note a few items worth reading recently, I thought I’d bundle them together for today’s post as just such a reminder. In human studies the evidence for exercise tends to be a matter of correlation more often than causation, but the corresponding animal studies, in which researchers can put individuals into groups by level of exercise and observe the results across the life span of a cohort, leave no doubt as to the benefits provided by regular exercise. The results over the long term remain better than anything a basically healthy individual can obtain from medical science today, say to say, though that statement won’t be true for many more years given the progress being made towards rejuvenation therapies. You can’t exercise your way to ensuring a life span of 100 years, it isn’t that large of an effect, but the benefits that can be realized are available, reliable, and free. It makes sense to take advantage of them.

The high level summary of the present research community consensus on the health benefits of exercise is that it, like many things in health and medicine, appears to have a U-shaped dose-response curve with the 80/20 point somewhere around about or a little above the standard recommendations for half an hour to an hour a day of moderate aerobic exercise. While elite athletes are shown to live a few years longer than the rest of us, it remains unclear as to whether that is due to the large amount of physical exercise or due to the fact that more robust people — who would live longer anyway — tend to have a better shot at succeeding in the world of professional athletics. At the other end of the dose-response curve, the growing use of accelerometers in studies has demonstrated that even modest levels of exercise, such as infrequent gardening or cleaning or walking, have noticeable correlations with health and mortality.

Continue reading “A Selection of Recent Research on Exercise and Aging” »

According to the American Academy of Allergy, Asthma & Immunology, more children are allergic to peanuts than to any other food. Unfortunately, the reactions can be lethal. In western cultures, peanut allergies are the leading cause of food-related anaphylaxis death. Needless to say, therefore, people with such allergies need to be protected against exposure to the nuts – and a skin patch may help provide that protection.

Made by biopharmaceutical company DBV Technologies, the Viaskin Peanut patch is applied to the arm or between the shoulder blades. It gradually delivers small amounts of peanut protein through the skin, allowing the wearer’s body to build up a tolerance for it.

The patch is currently the subject of an ongoing American study conducted by the Consortium of Food Allergy Research, and funded by the National Institute of Allergy and Infectious Diseases.

Politico: Write a transhumanist in in New York! http://www.politico.com/states/new-york/albany/story/2016/10…-in-106729 #transhumanism #Election2016 #ScienceCandidate

ALBANY — While Hillary Clinton and Donald Trump have debated issues such as immigration, gun control, and health care, neither of them has weighed in on the topic of a bill of rights for cyborgs.

Voters chagrined by that oversight do, however, have another option.

Continue reading “Worried about rights for cyborgs? There’s a write-in candidate for that” »

Continue reading “10 companies that want to make chemotherapy easier for patients — Bioquark Inc.” »

The idea of storing digital data in DNA seems like science fiction. At first glance, it might not seem obvious that a molecule can store data. The term “data storage” conjures up images of physical artifacts like CDs and data centers, not a microscopic molecule like DNA. But there are a number of reasons why DNA is an exciting option for information storage.

The status quo

We’re in the midst of a data explosion. We create vast amounts of information via our estimated 17 billion internet-connected devices: smartphones, cars, health trackers, and all other devices. As we continue to add sensors and network connectivity to physical devices we will produce more and more data. Similarly, as we bring online the 4.2 billion people who are currently offline, we will produce more and more data.

Continue reading “Can DNA Hard Drives Solve Our Looming Data Storage Crisis?” »

PCG-1α therapy shows promise in treating age-related decline.

It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer’s disease therapy that shows promise in mouse models. There is perhaps more uncertainty for Alzheimer’s than most other age-related conditions when it comes to the degree to which the models are a useful representation of the disease state in humans — which might go some way towards explaining the promising failures that litter the field. In the research here, the authors are aiming to suppress a step in the generation of amyloid-β, one of the proteins that aggregates in growing amounts and is associated with brain cell death in Alzheimer’s disease. They achieve this goal using gene therapy to increase the level of PGC-1α, which in turn reduces the level of an enzyme involved in the production of amyloid-β. Interestingly, increased levels of PGC-1α have in the past been shown to produce modest life extension in mice, along with some of the beneficial effects to health associated with calorie restriction.

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Continue reading “PGC-1α Gene Therapy Slows Alzheimer’s Progression in Mouse Model” »

Time to get the toothbrush out and brush for longevity!

For decades, research has suggested a link between oral health and inflammatory diseases affecting the entire body — in particular, heart attacks and strokes.

The results released today from a randomized trial of a novel plaque identifying toothpaste, (Plaque HD®), show statistically significant reductions in dental plaque and inflammation throughout the body. Inflammation throughout the body is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future heart attacks and strokes. These results, published today online ahead of print in the American Journal of Medicine, with an accompanying editorial by the editor-in-chief, show that Plaque HD®, produced statistically significant reductions in dental plaque and inflammation throughout the body as measured by hs-CRP.

Continue reading “Toothpaste significantly reduces dental plaque and inflammation throughout the body” »

A recent newspaper article under the headline “High street eye test can provide early indication of dementia” highlighted yet another complex connection between the eye and the brain.

This important eye-brain interface is still being researched and many disciplines are now working together to make fresh findings. But while most of us know that regular physical activity and eating healthily can help maintain or improve our well-being, few are aware of the importance of feeding our eyes with the right kind of light. Indeed, not experiencing the right quality and quantity of light could have adverse effects on hormonal changes, sleep patterns and may even be linked to obesity.

NAD+ therapy can supposedly increase your energy, focus, and metabolism, improve your cardiovascular health, and help you detox from alcohol and drugs. All this, of course, sounds incredibly unlikely—so I thought I’d see for myself.