New research from Harvard T.H. Chan School of Public Health and Ben Gurion University in Israel reveals that nearly one-third of people who stuck to a healthy diet didn’t lose any weight, but still saw impressive health improvements.

Even without shedding pounds, participants experienced key benefits to their cardiometabolic health. These included higher levels of HDL cholesterol (often called the “good” cholesterol), reduced levels of leptin (a hormone that drives hunger), and less visceral fat, which is the deep belly fat that can surround vital organs.

“We have been conditioned to equate weight loss with health, and weight loss-resistant individuals are often labeled as failures,” said lead author Anat Yaskolka Meir, postdoctoral research fellow in the Department of Epidemiology at Harvard Chan School. “Our findings reframe how we define clinical success. People who do not lose weight can improve their metabolism and reduce their long-term risk for disease. That’s a message of hope, not failure.”

An international study has, for the first time, revealed a strong and direct link between the rise of antibiotic-resistant bacteria and universal disinfection procedures applied to patients in intensive care units. Published in The Lancet Microbe, the study calls for a reassessment of health care guidelines on the widespread use of disinfectants.

“Our research highlights the unintended consequences of universal decolonization in a global context where antibiotic resistance is an increasing threat,” says Marco Oggioni, professor at the Department of Pharmacy and Biotechnology at the University of Bologna and one of the study’s authors. “Coordinated efforts to prevent antibiotic-resistant infections are crucial, but they must not prevent us from critically re-evaluating the tools we use to achieve these goals.”

Universal decolonization is a preventive procedure applied to patients upon admission to intensive care. The entire body is disinfected with chlorhexidine—a commonly used antiseptic also employed to sanitize medical devices and hospital surfaces—and an additional nasal treatment is administered with another disinfectant, mupirocin.

Scientists at St. Jude Children’s Research Hospital, the National Center for Genomic Analysis and the University of Adelaide have created a single-cell RNA analysis method that is 47 times cheaper and more scalable than other techniques.

Single-cell RNA sequencing provides scientists with important information about gene expression in health and disease. However, the technique is expensive and often prohibits analysis of large numbers of cells.

Scientists from St. Jude Children’s Research Hospital, the National Center for Genomic Analysis and the University of Adelaide have created a method that combines microscopy with single-cell RNA analysis to overcome these limitations. The technique called Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging (STAMP) can look at millions of single cells for a fraction of the cost of existing approaches.