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A form of gene therapy currently used to treat Parkinson’s disease may dramatically reduce alcohol use among chronic heavy drinkers, researchers at Oregon Health & Science University and institutions across the country have found.

The study in nonhuman primates showed that implanting a specific type of molecule that induces cell growth effectively resets the brain’s dopamine reward pathway in animals predisposed to heavy drinking. The gene therapy procedure involves brain surgery, and may be useful in the most severe cases of alcohol use disorder.

Already used in clinical trials to treat Parkinson’s disease, OHSU researchers found surgical treatment dramatically reduced chronic heavy drinking.

Continue reading “Study shows promise of gene therapy for alcohol use disorder” »

In a study of brains from contact sport players who died before reaching 30, more than 40% had chronic traumatic encephalopathy, oXavier?

The findings confirm that CTE can occur even in young people, but more work is needed to determine how CTE relates to clinical symptoms.

Millions of people worldwide get repetitive head impacts through various activities. These can lead to chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease that causes brain damage similar to that seen in Alzheimer’s disease. CTE has been reported in people as young as 17. The incidence of CTE in young people, however, is unknown.

Continue reading “Chronic traumatic encephalopathy in young athletes” »

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Fascinating 3D electron microscopy study by Parlakgül et al. wherein they compare the subcellular organization of liver tissue from lean and obese mice. The authors found substantial differences in endoplasmic reticulum (ER) organization. These ER differences were shown to directly influence metabolic health in a causal fashion, opening the doors to new ways of treating metabolic dysfunction. #electronmicroscopy #cellbiology #metabolism

Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.

After being diagnosed with acute lymphoblastic leukemia at age 5 and relapsing twice, Emily appeared to be out of treatment options.

Learn how research advances gave Emily her health back.

Learn how advances in cancer treatment and care have improved patients’ quality of life.

Continue reading “Offering Hope through Better Treatments and Care” »

In a recent study published in Science Advances, researchers from the California Institute of Technology, led by Dr. Wei Gao, have developed a machine learning (ML)–powered 3D-printed epifluidic electronic skin for multimodal health surveillance. This wearable platform enables real-time physical and chemical monitoring of health status.

Wearable health devices have the potential to revolutionize the medical world, offering real-time tracking, personalized treatments, and early diagnosis of diseases.

However, one of the main challenges with these devices is that they don’t track data at the molecular level, and their fabrication is challenging. Dr. Gao explained why this served as a motivation for their team.

People in the oldest stage of life who regularly engage in aerobic activities and strength training exercises perform better on cognitive tests than those who are either sedentary or participate only in aerobic exercise. That is the key finding of our new study, published in the journal GeroScience.

We assessed 184 cognitively healthy people ranging in age from 85 to 99. Each participant reported their exercise habits and underwent a comprehensive battery of neuropsychological tests that were designed to evaluate various dimensions of cognitive function.

We found that those who incorporated both aerobic exercises, such as swimming and cycling, and strength exercises like weightlifting into their routines – regardless of intensity and duration – had better mental agility, quicker thinking and greater ability to shift or adapt their thinking.

Recent studies have shown tire emissions to be a larger threat to global health than anyone realized—and EVs could make the problem worse.

And that is just health care. In 1940, there were 42 workers per beneficiary of Social Security. Today, there are only 2.8 workers per beneficiary, and that number is getting smaller. We are going broke, and the young men who will play a huge role in determining our nation’s future are going there with AI girlfriends in their pockets.

While the concept of an AI girlfriend may seem like a joke, it really isn’t that funny. It is enabling a generation of lonely men to stay lonely and childless, which will have devastating effects on the U.S. economy in less than a decade.