Lifeboat Foundation

Fort Lauderdale, FL — Life Extension has partnered with Insilico Medicine to introduce Ageless Cell, the first supplement in its GEROPROTECT line to promote healthy aging by inhibiting cellular senescence.

Cellular senescence is a natural part of the aging process where cells no longer function optimally, affecting organ function, cellular metabolism, and inflammatory response. The accumulation of these senescent cells contributes to the process of aging. The Ageless Cell supplements inhibit the effects of cellular senescence by acting as geroprotectors, or interventions aimed to increase longevity and impede the onset of age-related diseases by targeting and inhibiting senescence-inducing pathways and inhibiting the development of senescent cells.

The partnership with Insilico Medicine allowed researchers to use deep learning algorithms to comb through hundreds of studies and thousands of data points — a process that could have taken decades — to identify four key anti-aging nutrients: N-Acetyl-L-Cysteine (NAC), myricetin, gamma-tocotrienol, and EGCG. These compounds target pathways that are known to contribute to or protect against the development of senescent cells.

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Amazon’s Echo smart speakers just went in an unusual (but potentially very helpful) new direction. Meet Echo Look, an Alexa-powered camera designed around taking your own fashion photos and videos. If you want to show off your daily wardrobe, you just have to ask the Look to take a snapshot — you don’t have to take a selfie in front of a mirror to get a full-length picture. And since it includes a depth-sensing camera, it can blur the background to make shots pop. The real party tricks come when you’re not sure about your outfit, however.

The Look’s Style Check service blends AI algorithms with fashion specialist advice to provide a second opinion. Does that jacket really go with that shirt? The goal is to get you shopping for more clothes on Amazon, of course, but this could save you from having to ask friends for tips. The more feedback you provide, the better Style Check gets at determining what outfits work.

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2017 begins on Monday in Vancouver, Canada, and will explore the theme “The Future You.” If the future you is anything like the future us, you are likely curled up in a big cushy chair right now, devouring the contents of a book that flips your thinking. Below, some reading suggestions from the speaker program. Read, enjoy and stay tuned to the TED Blog for beat-by-beat coverage of the conference.

TED2017 begins on Monday in Vancouver, Canada, and will explore the theme “The Future You.” If the future you is anything like the future us, you are likely curled up in a big cushy chair right now, devouring the contents of a book that flips your thinking. Below, some reading suggestions from the speaker program. Read, enjoy and stay tuned to the TED Blog for beat-by-beat coverage of the conference.

Weapons of Math Destruction: How Big Data Increases Inequality and Threatens Democracy by Cathy O’Neil. The decisions that affect our lives are no longer made by humans — they’re made by algorithms. This might sound like a great way around bias and discrimination, but these things are often built right into our mathematical models. When it comes to college admissions, decisions on parole, applications to jobs and the affects of a bad credit score, O’Neil explores the unintended consequences of algorithms. (Read an excerpt.)

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Artificial intelligence algorithms are being taught to generate art, human voices, and even fiction stories all on their own—why not give them a shot at building new ways to treat disease?

Atomwise, a San Francisco-based startup and Y Combinator alum, has built a system it calls AtomNet (pdf), which attempts to generate potential drugs for diseases like Ebola and multiple sclerosis. The company has invited academic and non-profit researchers from around the country to detail which diseases they’re trying to generate treatments for, so AtomNet can take a shot. The academic labs will receive 72 different drugs that the neural network has found to have the highest probability of interacting with the disease, based on the molecular data it’s seen.

Atomwise’s system only generates potential drugs—the compounds created by the neural network aren’t guaranteed to be safe, and need to go through the same drug trials and safety checks as anything else on the market. The company believes that the speed at which it can generate trial-ready drugs based on previous safe molecular interactions is what sets it apart.

Continue reading “Artificial intelligence could build new drugs faster than any human team” »

Artificial intelligence picks up racial and gender biases when learning language from text, researchers say. Without any supervision, a machine learning algorithm learns to associate female names more with family words than career words, and black names as being more unpleasant than white names.

For a study published today in Science, researchers tested the bias of a common AI model, and then matched the results against a well-known psychological test that measures bias in humans. The team replicated in the algorithm all the psychological biases they tested, according to study co-author Aylin Caliskan, a post-doc at Princeton University. Because machine learning algorithms are so common, influencing everything from translation to scanning names on resumes, this research shows that the biases are pervasive, too.

“Language is a bridge to ideas, and a lot of algorithms are built on language in the real world,” says Megan Garcia, the director of New America’s California branch who has written about this so-called algorithmic bias. “So unless an alg is making a decision based only on numbers, this finding is going to be important.”

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Machine learning algorithms and artificial intelligence systems influence many aspects of people’s lives: news articles, movies to watch, people to spend time with, access to credit, and even the investment of capital. Algorithms have been empowered to make such decisions and take actions for the sake of efficiency and speed. Despite these gains, there are concerns about the rapid automation of jobs (even such jobs as journalism and radiology). A better understanding of attitudes toward and interactions with algorithms is essential precisely because of the aura of objectivity and infallibility cultures tend to ascribe to them. This report illustrates some of the shortcomings of algorithmic decisionmaking, identifies key themes around the problem of algorithmic errors and bias, and examines some approaches for combating these problems. This report highlights the added risks and complexities inherent in the use of algorithmic decisionmaking in public policy. The report ends with a survey of approaches for combating these problems.

“These re-engineered organisms will change our lives over the coming years, leading to cheaper drugs, ‘green’ means to fuel our cars and targeted therapies for attacking ‘superbugs’ and diseases, such as cancer,” wrote Drs. Ahmad Khalil and James Collins at Boston University, who were not involved in the study.

Our brains are often compared to computers, but in truth, the billions of cells in our bodies may be a better analogy. The squishy sacks of goop may seem a far cry from rigid chips and bundled wires, but cells are experts at taking inputs, running them through a complicated series of logic gates and producing the desired programmed output.

Take beta cells in the pancreas, which manufacture and store insulin. If they detect a large spike in blood sugar, then they release insulin; else they don’t. Each cell adheres to commands like these, allowing us—the organism—to operate normally.

Continue reading “Scientists Hacked a Cell’s DNA and Made a Biocomputer Out of It” »

Billionaire investor Jim Mellon has joined the push to solve age-related diseases and bring rejuvenation biotechnology to the world.

Billionaire biotechnology investor Jim Mellon has unveiled an investment in an ambitious new venture which seeks to tackle ageing and age-related diseases.

Insilico Medicine is a big data analytics company which says its mission is to ‘extend healthy longevity’.

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No one really knows how the most advanced algorithms do what they do. That could be a problem.