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Issues and Challenges in NSCLC Immunotherapy

Immunotherapy has revolutionized lung cancer treatment in the past decade. By reactivating the host’s immune system, immunotherapy significantly prolongs survival in some advanced lung cancer patients. However, resistance to immunotherapy is frequent, which manifests as a lack of initial response or clinical benefit to therapy (primary resistance) or tumor progression after the initial period of response (acquired resistance). Overcoming immunotherapy resistance is challenging owing to the complex and dynamic interplay among malignant cells and the defense system. This review aims to discuss the mechanisms that drive immunotherapy resistance and the innovative strategies implemented to overcome it in lung cancer.

The discovery of the immune checkpoint inhibitors (ICIs), represented by the monoclonal antibodies that block cytotoxic T−lymphocyte−associated protein 4 (CTLA-4), programmed death protein 1 (PD-1), and programmed death protein ligand 1 (PD-L1), has revolutionized the therapeutic landscape of lung cancer. The significant survival benefit derived from ICI-containing treatment has established it as the mainstay first-line therapy in patients with advanced or locally advanced non-small cell lung cancer (NSCLC) and extensive small-cell lung cancer (SCLC). Unprecedented long-term clinical benefit or even, in some cases, a complete recovery has been witnessed in lung cancer, particularly in patients with high PD-L1-expressing tumors (13). Currently, investigations are under way aimed at integrating immunotherapy in the treatment of early-stage lung cancer.

However, most patients with NSCLC develop primary resistance during ICI monotherapy and only 15 to 20% achieve partial or complete response (3). Acquired resistance also occurs in initially responding patients with advanced NSCLC treated with ICIs, after a median progression-free survival (PFS) of 4–10 months (49). The mechanisms of resistance to immunotherapy are not yet fully understood, and methods to overcome them must be developed. Herein, we discuss the pathways driving resistance to immunotherapy in lung cancer to help clinicians in their current practice, as well as identify future research priorities and treatment strategies.

Rethinking Memory Mechanisms of Foundation Agents in the Second Half: A Survey

The research of artificial intelligence is undergoing a paradigm shift from prioritizing model innovations over benchmark scores towards emphasizing problem definition and rigorous real-world evaluation. As the field enters the “second half,” the central challenge becomes real utility in long-horizon, dynamic, and user-dependent environments, where agents face context explosion and must continuously accumulate, manage, and selectively reuse large volumes of information across extended interactions. Memory, with hundreds of papers released this year, therefore emerges as the critical solution to fill the utility gap. In this survey, we provide a unified view of foundation agent memory along three dimensions: memory substrate (internal and external), cognitive mechanism (episodic, semantic, sensory, working, and procedural), and memory subject (agent- and user-centric). We then analyze how memory is instantiated and operated under different agent topologies and highlight learning policies over memory operations. Finally, we review evaluation benchmarks and metrics for assessing memory utility, and outline various open challenges and future directions.

Deep learning detects foodborne bacteria within three hours by eliminating debris misclassifications

Researchers have significantly enhanced an artificial intelligence tool used to rapidly detect bacterial contamination in food by eliminating misclassifications of food debris that looks like bacteria. Current methods to detect contamination of foods such as leafy greens, meat and cheese, which typically involve cultivating bacteria, often require specialized expertise and are time-consuming—taking several days to a week.

Luyao Ma, an assistant professor at Oregon State University, and her collaborators from the University of California, Davis, Korea University and Florida State University, have developed a deep learning-based model for rapid detection and classification of live bacteria using digital images of bacteria microcolonies. The method enables reliable detection within three hours. The findings are published in the journal npj Science of Food.

Their latest breakthrough involves training the model to distinguish bacteria from microscopic food debris to improve its accuracy. A model trained only on bacteria misclassified debris as bacteria more than 24% of the time. The enhanced model, trained on both bacteria and debris, eliminated misclassifications.

How to design a space station: Meet the Seattle company that’s helping define the look of the final frontier

How do you design a living space where there’s no up or down? That’s one of the challenges facing Teague, a Seattle-based design and innovation firm that advises space companies such as Blue Origin, Axiom Space and Voyager Technologies on how to lay out their orbital outposts.

Mike Mahoney, Teague’s senior director of space and defense programs, says the zero-gravity environment is the most interesting element to consider in space station design.

“You can’t put things on surfaces, right? You’re not going to have tables, necessarily, unless you can attach things to them, and they could be on any surface,” he told GeekWire. “So, directionality is a big factor. And knowing that opens up new opportunities. … You could have, let’s say, two scientists working in different orientations in the same area.”

World Modeling Workshop — Day 1

A fundamental desideratum of AI is the ability to model environment dynamics and transitions in response to both their own actions and external control signals. This capability, commonly referred to as world modeling (WM), is essential for prediction, planning, and generalization. Learning world models using deep learning has been an active area of research for nearly a decade. In recent years, the field has witnessed significant breakthroughs driven by advances in deep neural architectures and scalable learning paradigms. Multiple subfields, including self-supervised learning (SSL), generative modeling, reinforcement learning (RL), robotics, and large language models (LLMs), have tackled aspects of world modeling, often with different tools and methodologies. While these communities address overlapping challenges, they frequently operate in isolation. As a result, insights and progress in one area may go unnoticed in another, limiting opportunities for synthesis and collaboration. This workshop aims to bridge this gap between subfields of world modeling by fostering open dialogue, critical discussion, and cross-disciplinary exchange. By bringing together researchers from diverse backgrounds, from early-career researchers to established experts, we hope to establish a shared vocabulary, identify common challenges, and surface synergies that can move the field of world modeling forward.

ABCA1 protein releases molecular brakes on solid tumor immunotherapy, study finds

In recent years, cancer researchers have made major breakthroughs by using the body’s immune system to fight cancer. One of the most promising approaches, known as immune checkpoint blockade, works by releasing molecular “brakes” on T cells. This allows them to better recognize and attack cancer cells. While these therapies can be very effective for some patients, many solid tumors, including most forms of breast cancer, remain largely unaffected. Cancer Center at Illinois (CCIL) Program Co-leader Erik Nelson and his research group are working to understand why these treatments fail.

Elevated blood concentrations of cholesterol have long been linked to cancer outcomes. In a new study, they found that a protein called ABCA1 is involved in transporting cholesterol out of a type of immune cell called macrophages, and in so-doing shifts them to an “attack cancer” mode.

“Immune based therapies have revolutionized how we can treat cancer, basically taking the brakes off of a type of immune cell called T cells so they can attack cancer,” Nelson said. “While this approach works well for some patients, many so-called solid tumors fail to respond or develop resistance mechanisms.”

Breakthrough: Scientists Created a ‘Universal’ Kidney To Match Any Blood Type

After a decade of work, researchers are closer than ever to a key breakthrough in kidney transplants: being able to transfer kidneys from donors with different blood types than the recipients, which could significantly speed up waiting times and save lives.

In research published last year, a team from institutions across Canada and China reported creating a ‘universal’ kidney that, in theory, can be accepted by any patient.

Their test organ survived and functioned for several days in the body of a brain-dead recipient, whose family consented to the research.

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