Lifeboat Foundation

RNA polymerase

The key lies in mimicking nature’s machinery. The researchers identified RNA polymerase, a key enzyme that converts DNA into RNA, which is then used to make proteins. They designed two artificial nucleotides that flawlessly mimic the geometry of natural nucleotides. RNA polymerase readily accepted these novel additions when tested, seamlessly incorporating them into transcription.

A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research from The Australian National University (ANU) has found.

The discovery could pave the way for new and more effective drugs, without the nasty side effects of existing treatments. In addition to helping to manage severe autoimmune conditions, the breakthrough could also help treat all types of cancer. The work has been published in Science Advances.

The scientists have discovered a previously unknown function of the protein, known as DECTIN-1, which in its mutated state limits the production of T regulatory cells or so-called ‘guardian’ cells in the immune system.

SpaceX’s announcement of the new V2 Starship marks a significant commitment to innovation and improvement in the evolution of Starship, with potential game-changing advancements in technology and capabilities.

Questions to inspire discussion.

Continue reading “SpaceX’s V2 Starship: A Game-Changing Evolution in Space Technology” »

There has been a breakthrough when it comes to whale language that gives us a huge window into their communication.

Artificial intelligence researchers claim to have made the world’s first scientific discovery using a large language model, a breakthrough that suggests the technology behind ChatGPT and similar programs can generate information that goes beyond human knowledge.

The finding emerged from Google DeepMind, where scientists are investigating whether large language models, which underpin modern chatbots such as OpenAI’s ChatGPT and Google’s Bard, can do more than repackage information learned in training and come up with new insights.

“When we started the project there was no indication that it would produce something that’s genuinely new,” said Pushmeet Kohli, the head of AI for science at DeepMind. “As far as we know, this is the first time that a genuine, new scientific discovery has been made by a large language model.”

Stout has earned a spot on the Top500 computers list that was released Nov. 13.

Microsoft research releases Phi-2 and promptbase.

Phi-2 outperforms other existing small language models, yet it’s small enough to run on a laptop or mobile device.

Over the past few months, our Machine Learning Foundations team at Microsoft Research has released a suite of small language models (SLMs) called “Phi” that achieve remarkable performance on a variety of benchmarks. Our first model, the 1.3 billion parameter Phi-1 (opens in new tab), achieved state-of-the-art performance on Python coding among existing SLMs (specifically on the HumanEval and MBPP benchmarks). We then extended our focus to common sense reasoning and language understanding and created a new 1.3 billion parameter model named Phi-1.5 (opens in new tab), with performance comparable to models 5x larger.

Continue reading “Phi-2: The surprising power of small language models” »

Federal funding brings together experts to chart a viable path to realizing fusion energy as a clean power source.

The University of Rochester’s Laboratory for Laser Energetics (LLE) has received a four-year, $10 million award from the US Department of Energy’s (DOE) Office of Fusion Energy Science (FES) to lead a national research hub dedicated to advancing inertial fusion energy (IFE) science and technology.

The LLE-led inertial fusion energy hub—named IFE-COLoR, which stands for Inertial Fusion Energy-Consortium on LPI (laser-plasma interaction) Research—is one of only three such hubs in the nation selected by the DOE through competitive peer review. The award is part of a recent DOE initiative to stimulate IFE research and development by building on the momentum of scientists’ breakthrough in achieving ignition, or a fusion reaction that creates a net energy gain, last year.

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.