Lifeboat Foundation

The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and wellbeing benefits. There have been no published empirical studies of microdosing and the current legal and bureaucratic climate makes direct empirical investigation of the effects of psychedelics difficult. In Study One we conducted a systematic, observational investigation of individuals who microdose. We tracked the experiences of 98 microdosing participants, who provided daily ratings of psychological functioning over a six week period. 63 of these additionally completed a battery of psychometric measures tapping mood, attention, wellbeing, mystical experiences, personality, creativity, and sense of agency, at baseline and at completion of the study. Analyses of daily ratings revealed a general increase in reported psychological functioning across all measures on dosing days but limited evidence of residual effects on following days. Analyses of pre and post study measures revealed reductions in reported levels of depression and stress; lower levels of distractibility; increased absorption; and increased neuroticism. To better understand these findings, in Study Two we investigated pre-existing beliefs and expectations about the effects of microdosing in a sample of 263 naïve and experienced microdosers, so as to gauge expectancy bias. All participants believed that microdosing would have large and wide-ranging benefits in contrast to the limited outcomes reported by actual microdosers. Notably, the effects believed most likely to change were unrelated to the observed pattern of reported outcomes. The current results suggest that dose controlled empirical research on the impacts of microdosing on mental health and attentional capabilities are needed.

Citation: Polito V, Stevenson RJ (2019) A systematic study of microdosing psychedelics. PLoS ONE 14: e0211023. https://doi.org/10.1371/journal.pone.

Editor: Danilo Arnone, King’s College London, UNITED KINGDOM

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Here’s an important story I wrote on #cryonics for Quartz about a recent tragedy of a young girl and society’s reluctance to give people rights after death. I think something like “Danielle’s Law” could be important moving forward:

Cryogenics is facing legal hurdles for people who want their bodies to be frozen for the future.

Shaking a physical system typically heats it up, in the sense that the system continuously absorbs energy. When considering a circular shaking pattern, the amount of energy that is absorbed can potentially depend on the orientation of the circular drive (clockwise/anti-clockwise), a general phenomenon known as circular dichroism.

In 2017, Nathan Goldman (ULB, Brussels), Peter Zoller (IQOQI, Innsbruck) and coworkers predicted that circular dichroism can be quantized in quantum systems (heating is then constrained by strict integers) forming a “topological state.” According to this theoretical prediction, the quantization of energy absorption upon circular driving can be directly related to topology, a fundamental mathematical concept that characterizes these intriguing states of matter.

Writing in Nature Physics, the experimental group of Klaus Sengstock and Christof Weitenberg (Hamburg), in collaboration with the team of Nathan Goldman, reports on the first observation of quantized circular dichroism. Following the theoretical proposal of Goldman, Zoller et al., the experimentalists realized a topological state using an ultracold atomic gas subjected to laser light, and studied its heating properties upon circular shaking of the gas. By finely monitoring the heating rates of their system, for a wide range of driving frequencies, they were able to validate the quantization law predicted by Goldman, Zoller et al. in 2017, in agreement with the underlying topological state realized in the laboratory.

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Companies may have to license patents on genome editor from multiple places.

The global population aged 60 or over is growing faster than all younger age groups and faces the tide of chronic diseases threatening their quality of life and posing challenges to healthcare and economy systems. To better understand the underlying biology behind healthspan — the healthy period of life before the first chronic disease manifestation — the scientists from Gero and MIPT collaborated with the researchers from PolyOmica, the University of Edinburgh and other institutes to analyze genetic data and medical histories of over 300,000 people aged 37 to 73 made available by UK Biobank.

The study published today in Communications Biology was lead by Dr. Peter Fedichev and Prof. Yurii Aulchenko. It shows that the most prevalent chronic conditions such as cancer, diabetes, chronic obstructive pulmonary disease, stroke, dementia, and some others apparently share the common underlying mechanism that is aging itself.

«According to Gompertz mortality law, the risk of death from all causes increases exponentially after the age of 40 and doubles approximately every 8 years», explains Peter Fedichev, founder and CSO of Gero. «By analyzing the dynamics of disease incidence in the clinical data available from UKB, we observed that the risks of age-related diseases grow exponentially with age and double at a rate compatible with the Gompertz mortality law. This close relation between the most prevalent chronic diseases and mortality suggests that their risks could be driven by the same process, that is aging. This is why healthspan can be used as a natural proxy for investigation of the genetic factors controlling the rate of aging, the “holy grail” target for anti-aging interventions».

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Jack Beard, a professor in the University of Nebraska College of Law’s Space, Cyber and Telecommunications Law Program, told Politico that the Woomera Manual on the International Law of Military Space Operations “will become the definitive document on military and security law as it applies to space.”

The Woomera Manual won’t actually lay out any new guidelines. Instead it will organize and present the laws that are already on the books so that politicians, industry leaders, and others can make better informed decisions regarding activity in space.

Given the fact that the Outer Space Treaty, which banned military actions in outer space, has all but been tossed aside, it’s unclear how much they’ll actually listen.

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“For A New Crypto Legal System”

Earlier this week (on Sunday night, in fact), I came across a definition and understanding of “legal systems” that has really cleared up a lot of things that have been weighing heavily on my mind for a long time. Here it is:

Legal systems are protocols for the management of disputes.

Continue reading “Against Szabo’s Law, For A New Crypto Legal System” »

‘Right to Try’ law allows patients and drugmakers to circumvent the FDA’s rules on access to experimental drugs.

When a company reaches the top of the ladder, they typically kick it away so that others cannot climb up on it. The aim? To prevent competition. When this happens in the pharmaceutical world, in terms of patents, companies quickly apply for broad protection of their products, which can last decades, and, in doing so, they fence off entire research areas for others.

In this video, Tahir Amin an attorney Tahir Amin who specializes in patent law, explains how this “skewed” system hurts everyday people.