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Dr. Erin Duffy, Ph.D. & Kevin Outterson, ESQ — Combating Antibiotic-Resistant Bacteria (CARB-X)

Combating Antibiotic-Resistant Bacteria — Dr. Erin Duffy, Ph.D., Chief of Research & Development, and Kevin Outterson, ESQ., Executive Director, CARB-X.


The Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X — https://carb-x.org/) is a global non-profit partnership accelerating antibacterial products to address drug-resistant bacteria, a leading cause of death around the world. 1.27 million deaths worldwide were attributed to resistant bacterial infections in 2019.

The CARB-X portfolio is the world’s most scientifically diverse, early development pipeline of new antibiotics, vaccines, rapid diagnostics and other products and represents the only global partnership that integrates solutions for the prevention, diagnosis and treatment of life-threatening bacterial infections, translating innovation from basic research to first-in-human clinical trials.

Dr. Erin Duffy, PhD., is Chief of Research & Development at CARB-X and she has two decades of drug-discovery and problem-solving experience in the antibiotic arena. She was previously with Rib-X Pharmaceuticals (now Melinta Therapeutics) where in increasing roles she helped to build and sustain a team of researchers that translated the company’s scientific platform into next-generation and novel antibiotics that target the ribosome. Her team’s most recent achievements include the de novo design and optimization of a completely new class of antibiotics, the pyrrolocytosines, which were supported in part by CARB-X. Prior to Rib-X, Erin was the Associate Director of Innovative Discovery Technologies at Achillion Pharmaceuticals, responsible for building the structure and computational teams and platform for their antiviral efforts. She began her industrial career at Pfizer Central Research, in Groton, Connecticut, where she joined a team of computational and structural drug designers in multiple therapeutic areas. Erin was trained formally at Yale University, where she became a physical-organic chemist focused on defining computationally how small molecules interact and react in the group of Professor William L. Jorgensen. She expanded her experience to large molecules under the mentorship of Professor Axel Brunger, whose group at Yale was transitioning to a mix of computational and laboratory structural biology.

Kevin Outterson, ESQ., is Executive Director of CARB-X and is a global thought leader on business models for antibiotic development and use. He is Professor of Law and N. Neil Pike Scholar of Health and Disability Law at Boston University School of Law, where he leads multi-disciplinary teams to solve global health issues. Professor Outterson is the Executive Director and Principal Investigator of CARB-X and a partner in DRIVE-AB (aka Driving Reinvestment In Research And Development And Responsible Antibiotic Use) a project composed of 15 public and 7 private partners from 12 countries that is funded by the Innovative Medicines Initiative (IMI) joint undertaking between the European Union and the European Pharmaceutical Industry Association (EFPIA). He also leads the Social Innovation on Drug Resistance program at Boston University.

Surfing at the atomic scale: Scientists experimentally confirm new fundamental law for liquids

The first experimental evidence to validate a newly published universal law that provides insights into the complex energy states for liquids has been.


Sending miniature robots deep inside the human skull to treat brain disorders has long been the stuff of science fiction—but it could soon become reality, according to a California start-up.

Artificial intelligence is already upending geopolitics

The TechCrunch Global Affairs Project examines the increasingly intertwined relationship between the tech sector and global politics.

Geopolitical actors have always used technology to further their goals. Unlike other technologies, artificial intelligence (AI) is far more than a mere tool. We do not want to anthropomorphize AI or suggest that it has intentions of its own. It is not — yet — a moral agent. But it is fast becoming a primary determinant of our collective destiny. We believe that because of AI’s unique characteristics — and its impact on other fields, from biotechnologies to nanotechnologies — it is already threatening the foundations of global peace and security.

The rapid rate of AI technological development, paired with the breadth of new applications (the global AI market size is expected to grow more than ninefold from 2020 to 2028) means AI systems are being widely deployed without sufficient legal oversight or full consideration of their ethical impacts. This gap, often referred to as the pacing problem, has left legislatures and executive branches simply unable to cope.

Our DNA is Older Than Earth Itself — Where Did It Come From? — Oct 2, 2018

How can you prove that we may not be from here? The complexity of our DNA doubles every 600M years (Moores Law) so if you take the timeline back to where it intersects when life must have begun, it would be about 9.5B years ago, but the Earth has only been around for about 4.5B years. What gives?

This video is a short 1 min 12 second clip from a great documentary by Caroline Cory, “ET Contact: They Are Here”, available on iTunes:

https://itunes.apple.com/ca/movie/e-t-contact-they-are-here/id1286966239

Trailer: https://itunes.apple.com/ca/movie/e-t-contact-they-are-here/id1286966239

More info: https://www.imdb.com/title/tt7230004/

—About Making Contact Project

USPS is doubling its initial order of electric mail delivery trucks

USPS has been criticized for not ordering more EVs.


The United States Postal Service announced its initial order of 50,000 next-generation delivery vehicles, 10,019 of which will be battery-electric vehicles. It’s a notable number considering the agency’s resistance to calls for increasing the number of EVs in its future delivery fleet.

Originally, the postal service said it would purchase 165,000 next-generation mail trucks, only 10 percent of which will be battery-electric vehicles. President Joe Biden and congressional Democrats urged the agency to increase the number of EVs, but USPS determined there was no legal reason to change its plans.

Now, the postal service says it will increase its initial order of EVs from 5,000 to 10,019, determining it “makes good sense from an operational and financial perspective.”

Russia Forcing Google To Delist VPN Websites, But 400,000+ Russians Are Downloading VPNs Daily

Russia is forcing Google to delist URLs associated with virtual private networks, or VPNs, but almost half a million Russians are downloading the technology that allows them to obscure their internet usage and access government-blocked websites.

Clearly, Russians are looking for uncensored information about their government’s war against Ukraine.

“Surfshark conducted an analysis showing that the Russian telecoms regulator (Roskomnadzor) has forced Google to delist more than 36,000 URLs that link to VPN services over the past month,” a Surfshark representative told me via email. (The company offers a VPN product.) “The most significant spike of requests was recorded amid the second week of the war, when the Kremlin banned various media platforms, including Facebook, Twitter, YouTube, while others left due to a ‘fake news’ law.”

NASA Releases Details on how Starship Will be Part of its Return to the Moon

The path back to the moon is long and fraught with danger, both in the real, physical sense and also in the contractual, legal sense. NASA, the agency sponsoring the largest government-backed lunar program, Artemis, has already been feeling the pain on the contractual end. Legal battles have delayed the development of a critical component of the Artemis program – the Human Landing System (HLS). But now, the ball has started rolling again, and a NASA manager recently reported the progress and future vision of this vital part of the mission to the Institute of Electrical and Electronics Engineers at a conference.

Kent Chojnacki is the manager of NASA’s Systems Engineering & Integration Office. He recently gave a presentation entitled Human Landing System. While it only ran to six content slides, he provided some more details into how the agency is arranging its work with future contractors developing the part of the Artemis program that will take astronauts down to the lunar surface.

Not only will it take astronauts down to the lunar surface, but the HLS will also serve as their home there – at least at the beginning of the Artemis program. Eventually, the astronauts will build their own homes on the lunar surface. But at least at first, it will have to be capable of carrying all the tools, equipment, and supplies needed to complete any individual Artemis mission.

TOP 5 Female Humanoid Robots 2022 That Will Shock You | PRICE REVEALED!

PRICE REVEALED!🔔 Subscribe now for more Technology news, Future technology news, and Science.
news. In this age of innovation and technology, an increasing number of.
companies are developing extremely human-like robots that will.
collaborate attentively with actual humans in the hospitality or customer.
service sectors.
Such robots have a long history dating back to the 4th century when the.
concept of a humanoid robot first appeared in many different cultures.
around the world, including Greece, China, and even Japan!#humanodrobot #bostondynamics #artificialintelligence📺Interesting fact: Smart individuals watch the full video!

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High-Speed Train Builder Wins Appeal Over Land Use

(TNS) — The legal tug-of-war over development of waterfront land in Baltimore’s Westport neighborhood has tilted in favor of a high-speed maglev train operator seeking to build a passenger station on the site where a developer separately proposed housing.

The Court of Special Appeals, the state’s second-highest court, granted the appeal of Baltimore Washington Rapid Rail LLC, which is planning a $10 billion project to link Washington and Baltimore and eventually New York with a superconducting magnetic levitation rail system.

The opinion clears the way for Rapid Rail to pursue its eminent domain lawsuit against Westport property owner Stonewall Capital, prolonging a monthslong dispute.

AgeX Therapeutics: Targeting Biological Ageing | Dr Michael D. West

Have not heard from Dr West in awhile. Two things stood out in this technical hour: Telomerase in gene therapy has never been properly developed, and their iTR technology has not had animal trials as they wait for funding.


In this #webinar, Dr Michael West, a bioentrepreneur and CEO of AgeX Therapeutics, discussed the work of AgeX Therapeutics, their mission and plan to extend human health and longevity, and exciting new #technologies that could combat #ageing and unlock cellular immortality.

Register for upcoming #HealthyLongevity #webinar sessions at https://nus-sg.zoom.us/webinar/register/3016397215018/WN__sypkX6ZSomc7cGAkK3LbA
#NUSMedicine #webinarseries

References:
- Closing video source: https://www.youtube.com/watch?v=yoJ6LRCkNb0

Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.