Archive for the ‘life extension’ category: Page 12

Aug 20, 2020

Potential Link for Alzheimer’s Disease and Common Brain Disease That Mimics Its Symptoms

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Summary: Researchers identified a group of closely related genes that capture molecular links between Alzheimer’s and LATE, a common brain disorder that mimics Alzheimer’s symptoms.

Source: Brigham and Women’s Hospital

Alzheimer’s disease is one of the most common causes of dementia, and while most people might know someone who is affected by it, the genetic factors behind the disease are less known. A new study by investigators from Brigham and Women’s Hospital uncovered a group of closely related genes that may capture molecular links between Alzheimer’s disease and Limbic-predominant Age-related TDP-43 Encephalopathy, or LATE, a recently recognized common brain disorder that can mimic Alzheimer’s symptoms. LATE is often combined with Alzheimer’s disease to cause a more rapid cognitive decline. The study’s results are published in Neuron.

Aug 19, 2020

Anti-aging drug targets Alzheimer’s

Posted by in categories: biotech/medical, chemistry, food, life extension, neuroscience

Scientists investigating Alzheimer’s treatments at the Salk Institute have uncovered some key mechanisms that enable an experimental drug to reverse memory loss in mouse models of the disease. The discovery not only bodes well for the possibility of clinical trials, but provides researchers with a new target to consider in the wider development of compounds to counter the degenerative effects of the condition.

The research centers on a drug called CMS121, which is a synthetic version of a chemical called fisetin that occurs naturally in fruits and vegetables. The Salk team’s previous studies concerning CMS121 have produced some very promising results, with one paper published last year describing how the drug influences age-related metabolic pathways in the brain, protecting against the type of degeneration associated with Alzheimer’s. This followed earlier studies demonstrating how fisetin can prevent memory loss in mice engineered to develop Alzheimer’s.

Work continues at Salk to understand how exactly fisetin and the synthetic variant CMS121 produces these anti-aging effects on the brain. In their latest study, the researchers again turned to mice engineered to develop Alzheimer’s, which were administered daily doses of CMS121 from the age of nine months. This is the equivalent to middle age in humans, with the mice already exhibiting learning and memory problems before the treatment began.

Aug 19, 2020

Biological Age Test #4 in 2020: Getting Better or Getting Worse?

Posted by in categories: biotech/medical, life extension

My latest blood test results are in-how’s my biological age?

In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.

Aug 19, 2020

Study finds cancer-boosting culprit that multiplies with age

Posted by in categories: biotech/medical, life extension

“Observations of metastasising cells revealed something intriguing—a high level of something called methylmalonic acid (MMA), a metabolic byproduct that appears to accumulate as we get older.”

“So how does MMA induce these changes in cancer cells? The key seems to be in a sort of reprogramming that “switches on” a gene called SOX4.

Prior research has shown SOX4 encourages cancer cells to become more aggressive and prone to metastasis.

Continue reading “Study finds cancer-boosting culprit that multiplies with age” »

Aug 19, 2020

Researchers examine the role of muscle strength in aging cognitive health

Posted by in categories: biotech/medical, computing, life extension

Research is showing a strong link between handgrip strength, walking speed, and cognition, indicating how improved physical health could boost elderly minds.

Based at Barwon Health, in the heart of Geelong’s clinical precinct, researchers are working to identify the —such as changes in , muscle strength and physical performance—for developing sarcopenia (loss of muscle mass, strength and function with advancing age) across the lifespan.

This testing involves the Geelong Osteoporosis Study (GOS) which began in the early 1990s, gathering adult participants from the electoral roll in the Barwon Statistical Division. During recent follow-up testing, researchers also measured cognitive function through a computer-based program, in tandem with evaluations.

Aug 19, 2020

Study finds clues to aging in ‘junk’ DNA

Posted by in categories: biotech/medical, genetics, life extension

For decades, greater than 60% of the human genome was believed to be “junk DNA” that served little or no purpose in the course of human development. Recent research by Colorado State University is challenging this notion to show that junk DNA might be important after all.

A new study, published on June 5 in Aging Cell, found that a portion of noncoding genetic material, called repetitive element transcripts, might be an important biomarker of the aging process.

Tom LaRocca, an assistant professor in the Department of Health and Exercise Science and faculty member in the Columbine Heath Systems Center for Healthy Aging at CSU, led the study to investigate a growing body of evidence that repetitive elements—transposons and other sequences that occur in multiple copies in the —may become active over time as we age.

Aug 19, 2020

A Future Without Aging — Dr. Aubrey de Grey

Posted by in categories: biotech/medical, life extension

Aubrey interviewed by, um, alien scientists.

Our conversation covers the importance of non-academic institutions in science, strategies for combating for repair the damage of aging, and an exploration of how extending human lifespan will change the Earth. In Dr. de Gray’s perspective, age-related decline is a medical problem like any other that can be treated and cured by cutting edge technology. He’s devoted himself to this pursuit as a founder of the SENS Research Foundation, the Methuselah Foundation, and the medical startup AgeX.

Continue reading “A Future Without Aging — Dr. Aubrey de Grey” »

Aug 18, 2020

CD38 gets in the way of NR and NMN for increasing NAD+

Posted by in category: life extension

NR and NMN are popular ways to try to boost levels of NAD+, but that approach hasn’t worked every time in human studies. One reason for that may involve CD38, which degrades both NR and NMN. With the goal of boosting NAD+ levels during aging, why does CD38 increase with age, and what can be done about it? All that and more in this video!

Aug 17, 2020

The Shortest and Longest Living Dog Breeds in the World

Posted by in categories: biotech/medical, genetics, life extension

Every dog owner has their own reasons for getting a pet, whether it is companionship, protection, or simply to have a furry friend to walk with. Each different breed comes with perks and challenges, and owners must be prepared to accommodate each type of dog’s unique health requirements to maximize their lifespan, because the reality is that some dogs are genetically predisposed to live much longer than others.

In order to determine the shortest and longest living dog breeds in the world, 24/7 Tempo reviewed the study, “Methods and mortality results of a health survey of purebred dogs in the UK,” published in the Journal of Small Animal Practice. Breeds for which there was little data or low response rates on surveys sent to owners were not considered. Breeds that are not officially recognized by the American Kennel Club were also not considered. Breed popularity data, as well as height and weight data, comes from the AKC. The height refers to the height of the dog’s shoulder.

Numerous studies have determined that there is a significant link between the size of a dog and the length of its lifespan — larger dogs have noticeably shorter lifespans than smaller dogs, as they age at a faster rate. Yet size and lifespan do not correlate exactly, as certain types of dogs are especially prone to maladies like cancer or heart problems.

Continue reading “The Shortest and Longest Living Dog Breeds in the World” »

Aug 17, 2020

33 Crucial Terms Every Futurist, Transhumanist, and Philosopher Should Know Going Forward

Posted by in categories: ethics, existential risks, geopolitics, life extension, neuroscience, robotics/AI, singularity, transhumanism

We can’t evolve faster than our language does. Evolution is a linguistic, code-theoretic process. Do yourself a humongous favor, look over these 33 transhumanist neologisms. Here’s a fairly comprehensive glossary of thirty three newly-introduced concepts and terms from “The Syntellect Hypothesis: Five Paradigms of the Mind’s Evolution” by futurist, philosopher and evolutionary cyberneticist Alex M. Vikoulov. In parts written as an academic paper, in parts as a belletristic masterpiece, this recent book is an exceptionally easy read for an intellectual reader — a philosophical treatise that is fine-tuned with apt neologisms readily explained by given definitions and contextually… https://medium.com/@alexvikoulov/33-crucial-terms-every-futu…a1c8b993c8

#evolution #consciousness #futurism #transhumanism #philosophy

“A powerful work! As a transhumanist, I especially loved one of the main ideas of the book that the Syntellect Emergence, merging of us into one Global Mind, constitutes the quintessence of the coming Technological Singularity. The novel conceptual visions of mind-uploading and achieving digital immortality are equally fascinating. The Chrysalis Conjecture as a solution to the Fermi Paradox is mind-bending. I would highly recommend The Syntellect Hypothesis to anyone with transhumanist aspirations and exponential thinking!” -Zoltan Istvan, futurist, author, founder of the U.S. Transhumanist Party

Continue reading “33 Crucial Terms Every Futurist, Transhumanist, and Philosopher Should Know Going Forward” »

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