Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 13

Published in the Journal of the American Chemical Society, the research by scientists at King’s College London and their collaborators suggests that chromatin—the complex of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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This study develops organ-specific aging models using blood proteomics data from 53,000 UK Biobank participants. These models predict organ-specific diseases and risk of death and reveal that chronic diseases reflect faster aging in specific organs. Different lifestyles affect organ aging differently.

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The concept of computational consciousness and its potential impact on humanity is a topic of ongoing debate and speculation. While Artificial Intelligence (AI) has made significant advancements in recent years, we have not yet achieved a true computational consciousness capable of replicating the complexities of the human mind.

AI technologies are becoming increasingly sophisticated, performing tasks that were once exclusive to human intelligence. However, fundamental differences remain between AI and human consciousness. Human cognition is not purely computational; it encompasses emotions, subjective experiences, self-awareness, and other dimensions that machines have yet to replicate.

The rise of advanced AI systems will undoubtedly transform society, reshaping how we work, communicate, and interact with the digital world. AI enhances human capabilities, offering powerful tools for solving complex problems across diverse fields, from scientific research to healthcare. However, the ethical implications and potential risks associated with AI development must be carefully considered. Responsible AI deployment, emphasizing fairness, transparency, and accountability, is crucial.

In this evolving landscape, ETER9 introduces an avant-garde and experimental approach to AI-driven social networking. It redefines digital presence by allowing users to engage with AI entities known as ‘noids’ — autonomous digital counterparts designed to extend human presence beyond time and availability. Unlike traditional virtual assistants, noids act as independent extensions of their users, continuously learning from interactions to replicate communication styles and behaviors. These AI-driven entities engage with others, generate content, and maintain a user’s online presence, ensuring a persistent digital identity.

ETER9’s noids are not passive simulations; they dynamically evolve, fostering meaningful interactions and expanding the boundaries of virtual existence. Through advanced machine learning algorithms, they analyze user input, adapt to personal preferences, and refine their responses over time, creating an AI representation that closely mirrors its human counterpart. This unique integration of AI and social networking enables users to sustain an active online presence, even when they are not physically engaged.

The advent of autonomous digital counterparts in platforms like ETER9 raises profound questions about identity and authenticity in the digital age. While noids do not possess true consciousness, they provide a novel way for individuals to explore their own thoughts, behaviors, and social interactions. Acting as digital mirrors, they offer insights that encourage self-reflection and deeper understanding of one’s digital footprint.

As this frontier advances, it is essential to approach the development and interaction with digital counterparts thoughtfully. Issues such as privacy, data security, and ethical AI usage must be at the forefront. ETER9 is committed to ensuring user privacy and maintaining high ethical standards in the creation and functionality of its noids.

ETER9’s vision represents a paradigm shift in human-AI relationships. By bridging the gap between physical and virtual existence, it provides new avenues for creativity, collaboration, and self-expression. As we continue to explore the potential of AI-driven digital counterparts, it is crucial to embrace these innovations with mindful intent, recognizing that while AI can enhance and extend our digital presence, it is our humanity that remains the core of our existence.

As ETER9 pushes the boundaries of AI and virtual presence, one question lingers:

— Could these autonomous digital counterparts unlock deeper insights into human consciousness and the nature of our identity in the digital era?

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Continue reading “Urolithin A Rejuvenates Old Stem Cells (Clip)” | >

Dr. Masayo Takahashi graduated from Kyoto University’s Faculty of Medicine in 1986. In 1992, she completed her Ph.D. in Visual Pathology at Kyoto University’s Graduate School of Medicine. She first worked as a clinician, but later became interested in research following her studies in the United States in 1995. In 2005, her lab became the first in the world to successfully differentiate neural retina from embryonic stem cells. She is currently the project leader of the Laboratory for Retinal Regeneration at the RIKEN Center for Developmental Biology (CDB).

Recently in Japan they restored vision of three people using puliportent stem cells.

Then, in March 2017, Dr. Takahashi and her team made another important step forward. While the 2014 surgery had used cells generated from the patient’s own tissues, Dr. Takahashi and her team succeeded this time in the world’s first transplantation of RPE cells generated from iPS cells that originated from another person (called “allogeneic transplantation”) to treat a patient with wet-type AMD. Currently, the patient is being monitored for the possibility of rejection, which is a risk of allogeneic transplantation. Regarding the significance of the operation, Dr. Takahashi explains that “allogeneic transplantation substantially reduces the time and cost required in producing RPE cells, creating opportunities for even more patients to undergo surgeries. Hearing patients’ eager expectations firsthand when working as a clinician has also been a significant motivation.”

Dr. Takahashi’s team is currently making preparations for clinical studies that will target retinitis pigmentosa, a hereditary eye disease, by transplanting photoreceptor cells. “Having my mind set on wanting to see applications of iPS cells in treatments as quickly as possible, I have been actively involved in the creation of the regulations for their practical applications in regenerative medicine. In Japan, where clinical studies and clinical trials can be conducted at the same time, there is significant merit in the fact that research can be carried out by doctors who also work in medical settings. This helps ensure that they proceed with a sense of responsibility and strong ethics. Our advanced clinical studies have attracted the attention of researchers working in regenerative medicine in various countries. I intend to maintain a rapid pace of research so that we can treat the illnesses of as many patients as possible.”

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In this study, we have demonstrated the crucial role of NAD+ homeostasis, particularly through the de novo synthesis pathway mediated by Qprt, in maintaining spermatogenesis with age. The deletion of Qprt led to progressive declines in NAD+ levels, particularly after 6 months of age, which were associated with significant defects in germ cell survival and mitochondrial function in spermatocytes. These disruptions manifested as impaired progression through meiosis, defective DNA double-strand break repair, and abnormal meiotic sex chromosome inactivation. Our findings also highlight the therapeutic potential of NAD+ precursor supplementation, as nicotinamide riboside effectively rescued the observed spermatogenic abnormalities in Qprt-deficient mice, emphasizing the importance of NAD+ in reproductive health and aging.

NAD+ can be synthesized through three pathways: the Preiss-Handler pathway, the salvage pathway, and the de novo pathway (Liu et al. 2018 ; Harjes 2019). In the de novo pathway, the essential amino acid tryptophan serves as a substrate, with Qprt catalyzing the formation of nicotinic acid mononucleotide, which is subsequently converted into NAD+ via a series of enzymatic reactions in the Preiss-Handler pathway. Coordinated regulation of these three pathways is crucial for maintaining intracellular NAD+ levels, which are essential for cellular function, a decline in NAD+ levels can lead to various pathological and physiological conditions (Minhas et al. 2019 ; Zhang et al. 2019a). In this study, we identified that Qprt, the rate-limiting enzyme in the NAD+ de novo synthesis pathway, is predominantly expressed in spermatocytes within the testes.

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An international team of scientists, including researchers from Harvard University and the University of Zurich, analyzed clinical trial results 777 elderly Swiss adults to test the potential anti-aging benefits of supplements and exercise.

While there’s no perfect way to measure biological aging, the researchers used tools that help measure age-related decline in the cells and organs, including factors like brain health and heart health.

They looked at participants who underwent one of eight longevity treatments over three years, including exercising and supplementing omega-3s, vitamin D, or both.

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Josh Mitteldorf suggests new protocol for experimental young plasma therapy.

Scientists explore concentrated plasma infusions for stronger anti-ageing effects.

01-Feb-2025Key points from article :

Scientists have long observed the remarkable rejuvenation effects of young plasma in ageing rats, but translating these findings into human therapies has been slow due to intellectual property barriers and funding challenges. In the meantime, a niche industry has emerged in Texas, where ageing individuals can receive plasma infusions from young donors for tens of thousands of dollars. However, these treatments, which replace about 35% of a patient’s plasma, fall short of the dramatic regeneration seen in laboratory animals. Researchers suspect that the exosome dosages in these human procedures are too low to match the full rejuvenation potential seen in rats.

To address this, a new approach suggests concentrating young plasma by removing excess water, allowing for higher doses without overloading the circulatory system. Freeze-drying plasma, a long-standing technology, could be adapted to reconstitute plasma at three or more times its normal strength. However, modifications would be necessary—such as removing platelets to avoid clotting risks and adjusting albumin levels for safety.

A key question remains: Can young exosomes permanently reprogram the body’s ageing process, or will ongoing infusions be required? If the body starts producing its own youthful exosomes after treatment, the therapy could be a game-changer. If not, frequent infusions might be necessary, making the procedure less practical. While uncertainty remains, results from animal studies provide hope that young plasma could lead to longer-lasting rejuvenation in humans.

Continue reading “Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma” | >

Outer Space, Inner Space, and the Future of Networks.
Synopsis: Does the History, Dynamics, and Structure of our Universe give any evidence that it is inherently “Good”? Does it appear to be statistically protective of adapted complexity and intelligence? Which aspects of the big history of our universe appear to be random? Which are predictable? What drives universal and societal accelerating change, and why have they both been so stable? What has developed progressively in our universe, as opposed to merely evolving randomly? Will humanity’s future be to venture to the stars (outer space) or will we increasingly escape our physical universe, into physical and virtual inner space (the transcension hypothesis)? In Earth’s big history, what can we say about what has survived and improved? Do we see any progressive improvement in humanity’s thoughts or actions? When is anthropogenic risk existential or developmental (growing pains)? In either case, how can we minimize such risk? What values do well-built networks have? What can we learn about the nature of our most adaptive complex networks, to improve our personal, team, organizational, societal, global, and universal futures? I’ll touch on each of these vital questions, which I’ve been researching and writing about since 1999, and discussing with a community of scholars at Evo-Devo Universe (join us!) since 2008.

For fun background reading, see John’s Goodness of the Universe post on Centauri Dreams, and “Evolutionary Development: A Universal Perspective”, 2019.

John writes about Foresight Development (personal, team, organizational, societal, global, and universal), Accelerating Change, Evolutionary Development (Evo-Devo), Complex Adaptive Systems, Big History, Astrobiology, Outer and Inner Space, Human-Machine Merger, the Future of AI, Neuroscience, Mind Uploading, Cryonics and Brain Preservation, Postbiological Life, and the Values of Well-Built Networks.
He is CEO of Foresight University, founder of the Acceleration Studies Foundation, and co-founder of the Evo-Devo Universe research community, and the Brain Preservation Foundation. He is editor of Evolution, Development, and Complexity (Springer 2019), and Introduction to Foresight: Personal, Team, and Organizational Adaptiveness (Foresight U Press 2022). He is also author of The Transcension Hypothesis (2011), the proposal that universal development guides leading adaptive networks increasingly into physical and virtual inner space.

A talk for the ‘Stepping into the Future‘conference (April 2022).

The Goodness of the Universe: Outer Space, Inner Space, and the Future of Networks /w John Smart

Many thanks for tuning in!

Have any ideas about people to interview? Want to be notified about future events? Any comments about the STF series?

Continue reading “The Goodness of the Universe” | >