Lifeboat Foundation

Aubrey De Grey discusses the progress and potential of therapies related to his ideas on anti-aging medicine, including the four therapies that will be tested in a mouse rejuvenation trial. He also shares his thoughts on partnering with organizations and individuals in the field, integrating AI into his work, and the importance of structure in maximizing impact. Aubrey de Grey discusses the potential for Yamanaka factors to be used in organ rejuvenation, and the role of transcription factors in creating induced pluripotent stem cells. He also provides advice for those interested in getting involved in the field and shares his views on time management and productivity. Aubrey De Grey discusses the potential for reversing the pathology of aging to address mechanical issues and mentions promising research being conducted by MAIA Biotechnology on cancerous cells that express telomerase. He also expresses his optimism about the possibility of reaching “longevity escape velocity” within the next 15 years.

Youtube:
Aubrey De Grey links.
https://twitter.com/aubreydegrey?ref_src=twsrc%5Egoogle%7Ctw…r%5Eauthor.
https://www.levf.org/
https://www.linkedin.com/in/aubrey-de-grey-24260b/

Continue reading “Aubrey De Grey: longevity escape velocity, longevity, mouse rejuvenation, Altos Labs, Yamanaka factor” »

People age at different rates due to a variety of intrinsic and extrinsic factors, which can affect their biological age and their risk of developing diseases or experiencing early death. This is why two individuals who are both 50 years old may not have the same level of biological aging, despite having lived for the same number of years.

Lifestyle choices, such as diet and smoking, and illness all contribute to accelerating biological age beyond one’s chronological age. Researchers have discovered that grip strength, a measure of overall muscle strength, is linked to biological age in this way. In particular, the study, which was published in the Journal of Cachexia, Sarcopenia, and Muscle, found that people with weaker grip strength had older biological ages.

Researchers at Michigan Medicine modeled the relationship between biological age and grip strength of 1,274 middle-aged and older adults using three “age acceleration clocks” based on DNA.

This week our guest is business and technology reporter, Peter Ward. Earlier this year, Peter released his book The Price of Immortality: The Race to Live Forever, where he investigates the many movements and organizations that are seeking to extend human life, from the Church of Perpetual Life in Florida, to some of the biggest tech giants in Silicon Valley.

In this episode, we explore Peter’s findings, which takes us on a tour from cryonics to mind uploading, from supplements to gene editing, and much more. Along the way, we discuss the details of how one might actually achieve immortality, the details of senescent cells and telomeres, whether it’s better to live healthy than to live long, the scams and failures that seem to dominate the space, as well as the efforts that seem most promising.

Continue reading “The Failures and Opportunities of Immortality | Peter Ward, Feedback Loop, ep 75” »

Nuclear morphology changes with aging, but the role of these changes and the underlying mechanisms are not fully understood. The authors find that the nuclear envelope anchor protein ANC-1 in worms, and its counterpart nesprin-1 and nesprin-2 in mammals, promotes the degradation of nuclear components to limit nucleolar size and function in a soma longevity and germline immortality mechanism.

“She cooks, she cleans, and she still finds time to play ball with Elroy,” George and Jane Jetsons’ six-and-a-half-year-old son. Set in the year 2062 and described in the 1960s animated sitcom The Jetsons as an “aluminum-encased, battery-powered robotic maid” who is the “perfect answer for any modern family,” Rosie the Robot takes care of chores around the house while also serving as friend and confidante of mother Jane. Sarcastic and funny, Rosie is a hardworking nanny and aunt figure to children Elroy and Judy.

While many technologies The Jetsons predicted for 2062 have become reality, such as video calls and smart watches, the full realization of robots as the 1960s ideal friend and helper who makes life easier has yet to be fulfilled. For twenty-five years, roboticist Daniel Theobald has been on a mission to create robots that can solve the world’s most pressing problems. But rather than focus solely on making robots be more human, his calling has been to use them to help humans be more human.

Continue reading “Meet The Roboticist Working To Make Robots Help Us Be More Human” »

Ray Kurzweil, an American Jewish inventor and futurist, claims that within ten years, man will be able to defeat old age and death thanks to the accelerated development of technology.

My question in relation to Kurzweil’s statement is: What is so good about us constantly living all the time? Why live at all if we are never to die?

Continue reading “Ray Kurzweil Thoughts on Immortality — A Kabbalist’s Response” »

In this episode, David and Peter discuss aging as a disease, the technology needed to reverse aging, and tips and tricks to increase your lifespan.

David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents.
Read David’s book, Lifespan: Why We Age-and Why We Don’t Have To: https://a.co/d/85H3Mll.

Continue reading “Why Aging is a Disease With David Sinclair | EP #18 Moonshots and Mindsets” »

Year 2022 😗

Plastic foam like Styrofoam is a ubiquitous, harmful and nearly immortal single-use material that is long overdue for a good, green replacement — and Cruz Foam is here to supply it. The startup creates a durable yet backyard-compostable packing foam out of shrimp shells produced (and discarded) by the seafood industry. It recently extended its seed round to accommodate the interests of Leonardo DiCaprio and Ashton Kutcher, and is scaling up to meet the demands of its first major customer, Whirlpool.

I met Cruz Foam co-founder John Felts during the memorable Accelerator at Sea hosted by the Sustainable Ocean Alliance. His pitch made perfect sense: create a biodegradable alternative to expanded polystyrene (EPS) foam using a material provided in abundance by nature.

Continue reading “Cruz Foam taps DiCaprio and Kutcher in $3.5M greentech seed” »

New approaches to the biology of senescence can make lives longer and healthier.