Dr. Peter Fedichev, Ph.D. is the CEO of Gero (https://gero.ai/), a biotech company focused on hacking complex diseases, including aging, with AI for novel drug discovery, as well as digital biomarkers.
Gero’s models originate from the physics of complex dynamic systems, combining the potential of deep neural networks with the physical models to study dynamical processes and understand what drives diseases.
Turtles, unlike humans, do not continue to age once their bodies reach adulthood because they are “negligibly senescent.” It is theoretically possible for them to live indefinitely, although it is unlikely to happen in actuality. They will eventually die of injury, predation, or sickness. It has been documented that tortoises and their cousins, turtles, can live for up to two hundred years without showing any signs of aging. A turtle that is a hundred years old can experience the same feelings of youth as a tortoise that is thirty years old. This enviable trait may be found in both fish and amphibians. The idea of aging terrifies humans, and it is understandable why. Nobody wants to age slowly and painfully into a state of ill health and old age where death appears preferable to life. However, not everyone thinks this way. There are others who desire to live longer, perhaps even indefinitely. And while a life without aging might sound like something that could only be found in the pages of a fantasy story, research in the field of science suggests that this possibility is very much within our reach.
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Extending the limit of the human lifespan. The first immortal human has already been born. “The first human to live to 1,000 has already been born” – Dr. Aubrey de Grey. How far are we in understanding aging and death? Do we have to age or is it a matter of a choice? What is the future of immortality? Is it possible to be immortal and if yes — how far are we in implementing medical treatment and technology that can forestall this natural process we have always thought “is just how life is”. In this video I am reviewing the cutting-edge technologies and the pioneers in the field of extending life expectancy and reaching immortality eventually. Hint: is it closer than you might imagine!
Recent evidence points out the role of the gut microbiota in the aging process. However, the specific changes and relevant interventions remain unclear. In this study, Senescence Accelerated Mouse-Prone 8 (SAMP8) mice were divided into four groups; young-FMT-group transplanted fecal microbiota from young donors (2–3°months old) and old-FMT-group transplanted from old donors (10–11°months old); additionally, other two groups either adult mice injected with saline solution or untreated mice served as the saline and blank control groups, respectively. All mice were intervened from their 7-months-old until 13-months-old. The open field test at 9 and 11°months of age showed that the mice transplanted with gut microbiota from young donors had significantly better locomotor and exploration ability than those of transplanted with old-donors gut microbiota and those of saline control while was comparable with the blank control. 16S rRNA gene sequencing showed that the gut microbiome of recipient mice of young donors was altered at 11°months of age, whereas the alternation of the gut microbiome of old-donor recipient mice was at 9°months. For comparison, the recipient mice in the blank and saline control groups exhibited changes in the gut microbiome at 10°months of age. The hallmark of aging-related gut microbiome change was an increase in the relative abundance of Akkermansia, which was significantly higher in the recipients transplanted with feces from older donors than younger donors at 9°months of age. This study shows that fecal microbiota transplantation from younger donors can delay aging-related declines in locomotor and exploration ability in mice by changing the gut microbiome.
Aging is inherently accompanied by the decline of physical and mental abilities, including locomotor, cognition, and bodily functions, to subsequently cause frailty syndrome, neurodegenerative diseases, and other age-related diseases, which reduce the quality of life of the aging population (Hou et al., 2019). Aging mechanisms and anti-aging interventions have long been a major focus of biomedical research, which is particularly relevant given the rapidly aging society.
The gut is a major organ for nutrients absorption, metabolism, and immunity, and contains hundreds of millions of microorganisms and their metabolites, which comprise the gut microbiota (Heintz and Mair, 2014) that interacts with host cells and tissues (Huang et al., 2021). Our previous study reported continuous changes in the gut microbiome of centenarians during their transition from a healthy status to death. The most significant changes of gut microbial communities in the period were found to occur at 7°months prior to death, suggesting that this may be a turning point of significant changes in the gut microbiome of centenarians (Luan et al., 2020). Recent studies have revealed an important relationship between the gut microbiome and aging-related diseases such as Alzheimer disease (Ticinesi et al., 2018; Haran and McCormick, 2021), suggesting that the gut microbiome plays an essential role in the aging process.
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RIYADH, Saudi Arabia—(BUSINESS WIRE)— Hevolution Foundation, a non-profit organization that provides grants and early-stage investments to incentivize research and entrepreneurship in healthspan science, announces a new grants program to encourage research into the aging process in Saudi Arabia, as part of the growing Saudi scientific ecosystem. The program, Hevolution’s Open Call for Grant Applications in Saudi Arabia, will provide funding of up to 500,000 Saudi Riyals for local researchers with an interest in the mechanisms of aging.
“This grants program is the first of many through which we aim to encourage the development of the field of aging research in Saudi Arabia” Tweet this
“Saudi Arabia’s population is relatively young but has high rates of age-related conditions such as heart disease and diabetes,” commented Mehmood Khan, MD, Hevolution Foundation’s Chief Executive Officer. “Our hope is that by tackling the aging process itself, we can alleviate the burden of diseases and conditions of aging for the people of Saudi Arabia and worldwide. With this pilot program and others that we have in the works, we hope to enable Saudi Arabia’s scientific community to be a key player in the global charge to reduce the burden of age-related diseases and conditions that affect most of humanity.”
The Aging and Drug Discovery Conference (ARDD) 2022 is pleased to present David Sinclair from Harvard Medical School, who shares new unpublished results from his lab at Harvard Medical School.
Held in Copenhagen at the glorious Ceremonial Hall, this meeting gathers the most prominent figures of the aging and longevity research field, from scientists to clinicians, investors, developers, and everything in between. The fast growth of the conference is evidence of its great quality. In 2022 we had around 400 people on-site, and many others joined through the web.
The Inaugural Rejuvenation Startup Summit 2022, brought to you by the Forever Healthy Foundation, took place with over 400 participants from over 30 countries in October. It is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry. The Summit brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in founding or joining a startup – all aiming to create therapies to vastly extend the healthy human lifespan. We started to publish videos with a first set of selected speakers on the 2022 summit:
