Archive for the ‘life extension’ category: Page 15

Oct 12, 2023

SIRT2 Works Against Cardiac Aging in Mice and Monkeys

Posted by in category: life extension

Working with non-human primates, scientists have discovered that the protein SIRT2, a member of the sirtuin family, might play an important role in slowing cardiac aging [1].

In this study published in Nature Aging, the researchers used long-tailed macaques to elucidate the molecular aspects of cardiac aging using multi-omics analysis. Unlike short-lived mice and rats, non-human primates like these have hearts that closely resemble those of humans and, due to their relatively long lifespan, suffer from spontaneous heart conditions as well.

Oct 12, 2023

Unlocking immortality: the science of reversing aging

Posted by in categories: biotech/medical, chemistry, genetics, life extension, nanotechnology, science

When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.

This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.

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Oct 12, 2023

Could young blood be the key to reversing age-related cognitive decline?

Posted by in categories: biotech/medical, life extension, neuroscience

Researchers at the University of Auckland identify platelet factor 4 (PF4) in young blood as a key player in reversing age-related cognitive decline in mice. The study offers a promising avenue for treating dementia-related conditions and enhancing brain function in aging populations.

Oct 11, 2023

New AI model uncovers how and why the human brain ages

Posted by in categories: information science, life extension, robotics/AI

Researchers developed ‘HistoAge,’ an algorithm that unravels brain aging and neurodegenerative disorders.

As we age, our brains undergo structural and cellular changes influenced by intrinsic and external factors. Accelerated aging in the brain can result in an increased risk of neurodegenerative conditions, bipolar disorder, and mortality. In a bid to deeply understand how an aging brain works, researchers say they have built a powerful AI tool that can identify regions in the brain vulnerable to age-related changes.

The team used AI to develop an algorithm called ‘HistoAge,’ which predicts age at death based on the cellular composition of human brain tissue specimens with an average accuracy… More.

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Oct 10, 2023

Is the reversal of cellular aging possible through chemical means?

Posted by in categories: biotech/medical, chemistry, genetics, life extension

This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

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Oct 10, 2023

Chair Elect of the American Medical Association (AMA) Michael Suk at Longevity Summit Dublin 2023

Posted by in categories: biotech/medical, life extension

LEV becoming mainstream medicine.

Oct 10, 2023

The Blood of Exceptionally Long-Lived People Shows Key Differences

Posted by in categories: biotech/medical, genetics, life extension

Centenarians, once considered rare, have become commonplace. Indeed, they are the fastest-growing demographic group of the world’s population, with numbers roughly doubling every ten years since the 1970s.

How long humans can live, and what determines a long and healthy life, have been of interest for as long as we know. Plato and Aristotle discussed and wrote about the ageing process over 2,300 years ago.

The pursuit of understanding the secrets behind exceptional longevity isn’t easy, however. It involves unravelling the complex interplay of genetic predisposition and lifestyle factors and how they interact throughout a person’s life.

Oct 10, 2023

Tech billionaire on journey to immortality says there is a ‘low probability’ humans will survive without AI

Posted by in categories: life extension, robotics/AI

Tech mogul Bryan Johnson, who is on a quest to reverse aging, said he does not believe humans will survive without the help of artificial intelligence.

Oct 10, 2023

Spheroids vs. Organoids—A Data-Driven Approach for 3D Culture Model Selection

Posted by in categories: bioengineering, biotech/medical, life extension

In this October 13 Learning Lab, Hilary Sherman, a Senior Scientist in the Corning Life Sciences Applications Lab, and Robert Padilla, a Field Application Scientist at Corning, dive into the topic of 3D culture techniques and why these technologies should be a part of any researcher’s repertoire.

Three-dimensional (3D) cultures such as spheroids and organoids are an important part of the research model market, helping to close the gap between cell cultures and animal models. Both organoids and spheroids have been used to create in vivo-like tissue models of cancer subtypes to study novel therapies and to make models for tissue engineering and regenerative medicine studies. But there are some key differences, with important implications for various applications. The right tool for a project is not always obvious. For spheroids and organoids, knowing where the cultures are similar and where they differ will help scientists select the best resource for their projects the first time around.

Oct 9, 2023

Frozen Bodies Brought Back to Life? Cryogenics and the Science of Immortality

Posted by in categories: biotech/medical, life extension, science

The idea of postponing or even reversing the ageing process has always fascinated humanity. Some claim that immortality will be possible as little as thirty years from now – but will it just be for the rich?

Our team visited research laboratories working on this objective and interviewed the world’s top researchers in the field. We ask just how long humans might be able to live, and what it could involve.

Continue reading “Frozen Bodies Brought Back to Life? Cryogenics and the Science of Immortality” »

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