Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 15

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Researchers have developed AI-driven evaluation standards to enhance ageing-related interventions, aiming to improve health outcomes and longevity through personalized, reliable recommendations.

Researchers from the Yong Loo Lin School of Medicine at the National University of Singapore (NUS Medicine) and the Institute for Biostatistics and Informatics in Medicine and Aging Research at Rostock University Medical Center in Germany conducted a collaborative study on the use of advanced AI tools, such as Large Language Models (LLMs), to enhance the evaluation of ageing-related interventions and provide personalized recommendations. Their findings were published in the journal Ageing Research Reviews.

Ageing research generates vast amounts of data, making it challenging to assess the safety and effectiveness of interventions like new medications, dietary modifications, or exercise regimens. This study explored how AI can streamline data analysis with greater efficiency and accuracy.

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People with shorter telomeres — the protective caps at the ends of their chromosomes — may have a higher risk of developing age-related brain diseases such as stroke, dementia, and late-life depression (typically diagnosed at age 60 or older). This finding comes from a preliminary study set to be presented at the American Stroke Association’s International Stroke Conference 2025, a leading global event for stroke and brain health research, taking place in Los Angeles from February 5–7, 2025.

Telomere length in white blood cells (leukocytes), known as leukocyte telomere length, is a well-established marker of biological aging. As people age, telomeres naturally shorten, reducing their ability to protect chromosomes, which accelerates cellular aging and increases vulnerability to age-related diseases. While telomere length is partly determined by genetics, ancestry, and gender, it is also influenced by lifestyle factors and environmental stressors such as diet, exercise, and pollution.

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These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Transthyretin, a small but crucial protein, plays a vital role in transporting hormones through the blood and spinal fluid. However, when it misfolds after secretion, it can lead to serious health problems. Misfolded transthyretin forms toxic clumps in the heart and along nerves, causing transthyretin amyloidosis (ATTR)—a progressive and often fatal disease. ATTR affects up to 25% of men over 80, leading to symptoms such as shortness of breath, dizziness, and numbness or tingling in the extremities.

In a breakthrough study, researchers at Scripps Research have revealed new structural insights into transthyretin. Their findings, published in Nature Structural & Molecular Biology.

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The data inscribed into the crystal is carefully annotated with universal elements like hydrogen, oxygen, carbon, and nitrogen, as well as the four DNA bases—adenine, cytosine, guanine, and thymine—that make up the genetic code. Additionally, the molecular structure of DNA and the arrangement of genes within chromosomes are depicted, offering clear instructions on how to interpret the genetic information stored within.

However, it is important to note that the 5D memory crystals require a highly specialized skill set and advanced equipment to inscribe and read the data stored within the crystals, so those looking to re-establish the human race after an extinction event may have to refer to more traditional means.

The crystal, made from fused quartz, is one of the most chemically and thermally resilient materials known on Earth, and can endure temperatures as high as 1000°C, resist direct impact forces up to 10 tons per square centimeter, and is unaffected by long-term exposure to cosmic radiation. The longevity and storage capacity of the 5D memory crystal earned it a Guinness World Record in 2014 for being the most durable data storage material ever created.

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We could soon live to the age of 150, medics claim.

They say more of us will reach the massive milestone thanks to modern tech, new medicines and healthy living. Longevity medicine expert Dr Debonneuil said: If the current trend continues, we could see individuals living to 140 or 150 in good health.

While that might sound sensational, it’s grounded in science and the longevity field is booming because of these breakthroughs.” Dr Debonneuil spoke after a first-of-its-kind study, Rejuvenation Olympics, produced promising anti-ageing results. He continued: “One of the guys taking part is in his 60’s but biologically he resembles someone in their later 30’s.

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GAINESVILLE, Fla. — As humans age, we develop chronic inflammation in our blood and tissues that gradually decreases the function of blood stem cells in our bone marrow. These defects harm blood cell production and the immune system, often leading to a slew of complications and weakening responses to chemotherapy.

Now, UF Health Cancer Center researchers have discovered a way to prevent this inflammation, called “inflammaging,” by systemically targeting a protein. The findings in mice, published Jan. 3 in Science Immunology, could pave the way for therapies aimed at preserving an aging blood system, with implications for cancer treatments and aging-related diseases, including anemias, infections, and blood cancers.

“We set out to determine if we could fully preserve and rejuvenate blood stem cell function during the course of aging, a goal that had remained largely elusive so far,” said Jason Butler, Ph.D., a professor and vice chief of research in the UF Division of Hematology and Oncology and a member of the UF Health Cancer Center, who led the new study.

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A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1].

Protecting DNA

Telomere shortening is a well-known hallmark of aging. Telomeres are protective DNA sequences at the ends of the chromosomes. In most human cells, they become shorter with each division.

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NAD, a vital molecule for cellular energy and DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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