In their study, published in Mechanobiology in Medicine, the researchers discovered that the protein responsible for binding neural stem cells in the human brain, neuro-cadherin, also plays a key role in stimulating their differentiation.
Neural stem cells are early-stage, unspecialized cells that have the ability to differentiate, or develop, into various types of neurons and non-neuronal cells of the central nervous system.
As the first generation that interacted with digital technology reaches an age where dementia risks emerge, scientists have asked the question: Is there a correlation between digital technology use and an increased risk of dementia? With the phrases “brain rot” and “brain drain” circulating on social media, it would appear that most people would assume the answer is yes.
However, a new study in Nature Human Behavior by neuroscientists at Baylor University and the University of Texas at Austin Dell Medical School reveals the opposite—digital technologies are actually associated with reduced cognitive decline.
The study, “A meta-analysis of technology use and cognitive aging,” was sparked by the ongoing concern about the passive activity of digital technologies and their relation to accelerating risks of dementia. Study co-authors are Jared F. Benge, Ph.D., clinical neuropsychologist and associate professor of neurology at Dell Medical School and UT Health Austin’s Comprehensive Memory Center within the Mulva Clinic for the Neurosciences, and Michael K. Scullin, Ph.D., associate professor of psychology and neuroscience at Baylor.
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Low frequency ultrasound was used to reverse the senescence of cells and when applied to mice led to increased physical performance, improved appearance and…
A new study from Weill Cornell Medicine provides insights into how cells maintain the tiny end caps of chromosomes as they divide, a key process in keeping cells healthy. Using yeast, the researchers reveal protein interactions that could explain how the enzyme telomerase is tightly regulated to prevent cells from dividing uncontrollably or aging prematurely.
The preclinical study, published April 17 in Nucleic Acids Research, brings us closer to understanding the mechanisms behind aging and cancer.
Before cells divide, they replicate the double-stranded DNA of each chromosome. The replication machinery does a good job of copying the nucleotide sequences until it gets to the telomeres, the end caps of chromosomes that safeguard the genetic material from damage and normally shorten with aging. That’s when telomerase steps in and produces an overhang in which one DNA strand is a little longer than the other.
Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that’s gaining mainstream scientific acceptance after initial skepticism.
The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider’s assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman’s venture), offering candid insights about which approaches show the most promise and why Google’s Calico has struggled despite substantial resources.
Regulatory innovation emerges as a crucial accelerator for progress. Montana’s groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.
At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.
Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50–50 chance of reaching \.
