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Archive for the ‘life extension’ category: Page 184

Jun 28, 2022

Mitochondrial uncoupling attenuates sarcopenic obesity

Posted by in categories: biotech/medical, life extension

Mitochondrial uncoupling by agents such as BAM15 may mitigate age-related decline in muscle mass and function by molecular and cellular bioenergetic adaptations that confer protection against sarcopenic obesity.


Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously identified that a mitochondrial-targeted furazano[3,4-b]pyrazine named BAM15 is orally available and selectively lowers respiratory coupling efficiency and protects against diet-induced obesity in mice. Here, we tested the hypothesis that mitochondrial uncoupling simultaneously attenuates loss of muscle function and weight gain in a mouse model of sarcopenic obesity.

Jun 28, 2022

Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration

Posted by in categories: biotech/medical, life extension

Circa 2018 immortality of the kidneys.


Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting their differentiation and angiogenic potential. Recent studies reported that specific abnormalities caused by the non-inherited disease are often retained in induced pluripotent stem cell (iPSC)-derived products obtained from patients. Thus, it is indispensable to first assess whether iPSCs derived from patients with CKD due to non-inherited disease (CKD-iPSCs) have the ability to generate kidneys.

Jun 28, 2022

Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats

Posted by in categories: biotech/medical, chemistry, genetics, life extension, neuroscience

Circa 2021 First breakthrough in immortality of the eyes of rats using the inducing of pluripotent stem cells in the eye. Which will eventually lead to immortality of the human eye.


The retina is neural tissue located in the posterior part of the eye and is an extension of the central nervous system (CNS), which has limited regenerative potential once damaged1. Therefore, to maintain homeostasis of the retinal microenvironment and protect itself from harmful stimuli, the retina has a unique structure consisting of inner and outer blood-retinal barriers (BRBs)2,3,4. The outer BRB is mainly composed of retinal pigment epithelial (RPE) cells, which support photoreceptor cells, the primary neurons in the retina, and play a significant role in the pathogenesis of retinal degenerative disorders, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP)5,6,7,8,9. These disorders are commonly characterized by the irreversible loss of photoreceptor cells and RPE cells, and the only fundamental treatment for these retinal degenerative disorders is replacement of damaged or atrophied cells10,11,12. Thus, regenerative treatments, such as stem cell transplantation, are emerging as attractive options for targeting retinal degeneration that was previously considered untreatable13.

RP refers to a set of hereditary retinal degenerative disorders that initially involve photoreceptors and leads to subsequent RPE cell damage; it affects 1 in 4,000 individuals worldwide9. Due to its inherent nature, extensive genetic studies are ongoing, and more than 50 causal genes have been identified14. Among the causal genes, PDE6B is a gene that encodes rod cGMP-phosphodiesterase, which is a critical component of the biochemical light transduction pathway9. Although various molecular and genetic studies have identified the pathomechanisms of RP, attempts to restore vision in patients with RP have failed. To overcome this issue, preclinical stem cell-based studies involving transient dosing or permanent implantation of pluripotent stem cells are being conducted10,11,15,16.

Continue reading “Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats” »

Jun 27, 2022

Self-sensing artificial muscle-based on liquid crystal elastomer and low-melting point alloys

Posted by in categories: bioengineering, biotech/medical, cyborgs, food, life extension, robotics/AI, security

Materials scientists and bioengineers at the intersection of regenerative medicine and bioinspired materials seek to develop shape-programmable artificial muscles with self-sensing capabilities for applications in medicine. In a new report now published in Science Advances, Haoran Liu and a team of researchers in systems and communications engineering at the Frontier Institute of Science and Technology, Jiaotong University, China, were inspired by the coupled behavior of muscles, bones, and nerve systems of mammals and other living organisms to create a multifunctional artificial muscle in the lab. The construct contained polydopamine-coated liquid crystal elastomer (LCE) and low-melting point alloys (LMPA) in a concentric tube or rod. While the team adopted the outer liquid crystal-elastomer to mimic reversible contraction and recovery, they implemented the inner low-melting point alloy for deformation locking and to detect resistance mechanics, much like bone and nerve functions, respectively. The artificial muscle demonstrated a range of performances, including regulated bending and deformation to support heavy objects, and is a direct and effective approach to the design of biomimetic soft devices.

Soft robotics inspired by the skeleton–muscle–nerve system

Scientists aim to implement biocompatibility between soft robotic elements and human beings for assisted movement and high load-bearing capacity; however, such efforts are challenging. Most traditional robots are still in use in industrial, agricultural and aerospace settings for high-precision sensor-based, load-bearing applications. Several functional soft robots contrastingly depend on materials to improve the security of human-machine interactions. Soft robots are therefore complementary to hard robots and have tremendous potential for applications. Biomimetic constructs have also provided alternative inspiration to emulate the skeleton-muscle-nerve system to facilitate agile movement and quick reaction or thinking, with a unique body shape to fit tasks and perform diverse physiological functions. In this work, Liu et al were inspired by the fascinating idea of biomimicry to develop multifunctional artificial muscles for smart applications.

Jun 27, 2022

The Origins of Our Blood May Not Be What We Thought

Posted by in categories: biotech/medical, life extension

‘Barcoding’ studies discovered two independent sources for blood cells in mice. If confirmed in humans, our understanding of blood cancers, bone marrow transplants, and the aging immune system will change.

The origins of our blood may not be quite what we thought. Using cellular “barcoding” in mice, groundbreaking research finds that blood cells originate not from one type of mother cell, but two, with potential implications for blood cancers, bone marrow transplant, and immunology. Fernando Camargo, PhD, of the Stem Cell Program at Boston Children’s Hospital led the study, published in the journal Nature on June 15, 2022.

“Historically, people have believed that most of our blood comes from a very small number of cells that eventually become blood stem cells, also known as hematopoietic stem cells,” says Camargo, who is also a member of the Harvard Stem Cell Institute and a professor at Harvard University. “We were surprised to find another group of progenitor cells that do not come from stem cells. They make most of the blood in fetal life until young adulthood, and then gradually start decreasing.”

Jun 26, 2022

Bill Faloon presents a classic Age Reversal Update

Posted by in categories: education, life extension

https://www.youtube.com/supported_browsers?next_url=https://…ture=share

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Jun 25, 2022

Harold Katcher’s E5/Elixir (Young Plasma) Rat Trial Results

Posted by in categories: genetics, life extension

Just a quick update in the E5 experiment all control rats have died and 3 treated rats remain.


Does the survival curve reflect the epigenetic age reduction seen in previous experiment? Blog post from the Live Forever Club.

Continue reading “Harold Katcher’s E5/Elixir (Young Plasma) Rat Trial Results” »

Jun 25, 2022

Human Longevity and Freedom Acquisition in merger talks

Posted by in categories: biotech/medical, business, life extension

Human Longevity Inc, which was built by the pioneers of the human genome sequencing effort, and Freedom Acquisition Corporation, a publicly traded special purpose acquisition company (SPAC), have announced that they have signed a non-binding letter of intent for a proposed business combination that would result in HLI becoming a publicly listed company. Assuming everything ticks along as planned, the parties currently expect to seek approval from Freedom’s shareholders by the first quarter of 2023.

Longevity. Technology: Unicorns are the stuff of legends and headlines, and while there can be no assurance that a definitive agreement will be entered into or that the proposed transaction will be consummated, the speculation is delicious because longevity start-ups with billion-dollar valuations mean more visible, accelerating progress for the sector.

The proposed transaction values the combined company at approximately $1 billion, providing HLI with funding to pursue growth and technology innovation – watch this space!

Jun 24, 2022

The Goodness of the Universe — John Smart

Posted by in categories: cryonics, life extension, neuroscience, robotics/AI

Outer Space, Inner Space, and the Future of Networks.
Synopsis: Does the History, Dynamics, and Structure of our Universe give any evidence that it is inherently “Good”? Does it appear to be statistically protective of adapted complexity and intelligence? Which aspects of the big history of our universe appear to be random? Which are predictable? What drives universal and societal accelerating change, and why have they both been so stable? What has developed progressively in our universe, as opposed to merely evolving randomly? Will humanity’s future be to venture to the stars (outer space) or will we increasingly escape our physical universe, into physical and virtual inner space (the transcension hypothesis)? In Earth’s big history, what can we say about what has survived and improved? Do we see any progressive improvement in humanity’s thoughts or actions? When is anthropogenic risk existential or developmental (growing pains)? In either case, how can we minimize such risk? What values do well-built networks have? What can we learn about the nature of our most adaptive complex networks, to improve our personal, team, organizational, societal, global, and universal futures? I’ll touch on each of these vital questions, which I’ve been researching and writing about since 1999, and discussing with a community of scholars at Evo-Devo Universe (join us!) since 2008.

For fun background reading, see John’s Goodness of the Universe post on Centauri Dreams, and “Evolutionary Development: A Universal Perspective”, 2019.

Continue reading “The Goodness of the Universe — John Smart” »

Jun 24, 2022

Secrets of aging revealed in largest study on longevity, aging in reptiles and amphibians

Posted by in categories: biological, life extension

At 190 years old, Jonathan the Seychelles giant tortoise recently made news for being the “oldest living land animal in the world.” Although, anecdotal evidence like this exists that some species of turtles and other ectotherms—or ‘cold-blooded’ animals—live a long time, evidence is spotty and mostly focused on animals living in zoos or a few individuals living in the wild. Now, an international team of 114 scientists, led by Penn State and Northeastern Illinois University, reports the most comprehensive study of aging and longevity to date comprising data collected in the wild from 107 populations of 77 species of reptiles and amphibians worldwide.

Among their many findings, which they report today in the journal Science, the researchers documented for the first time that , crocodilians and salamanders have particularly low aging rates and extended lifespans for their sizes. The team also found that protective phenotypes, such as the hard shells of most turtle species, contribute to slower aging, and in some cases even ‘negligible aging’—or lack of biological aging.

“Anecdotal evidence exists that some reptiles and amphibians age slowly and have long lifespans, but until now no one has actually studied this on a large scale across numerous species in the wild,” said David Miller, senior author and associate professor of wildlife population ecology, Penn State. “If we can understand what allows some animals to age more slowly, we can better understand aging in humans, and we can also inform conservation strategies for reptiles and amphibians, many of which are threatened or endangered.”