Archive for the ‘life extension’ category: Page 19

Jun 13, 2020

David Sinclair on Aging and How we can reset our age

Posted by in categories: biotech/medical, education, genetics, life extension

Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.

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Jun 12, 2020

DARPA, Biotech, and Human Enhancement — ideaXme — Dr. Eric Van Gieson — Biological Technologies Office (BTO) Epigenetic CHaracterization and Observation (ECHO) Program — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, defense, DNA, genetics, government, health, life extension, military

Jun 12, 2020

NTZ: a tool for the rejuvenation field

Posted by in category: life extension

Therefore, in 2020, we launched an initiative to focus NTZ’s efforts on the rejuvenation field, and to establish a worldwide network of translators of the field in order to turn NTZ into a tool for the whole field in the area of translation. This means that if a person or an entity in the rejuvenation field needs a translation which requires a translator familiar with the topic, with sufficient technical knowledge and reliability in any language pair, they only need to contact NTZ. Translators specialized in the science of rejuvenation know the technical terms, the main theories of aging, the most influential scientists, the key organizations, the most promising companies and the most active investors in the field. They are also aware of the importance of the rejuvenation field and are part of the worldwide effort to end an immense source of suffering in the world: aging and death caused by the inability to undo it.

Jun 10, 2020

Stem cell-loaded microneedles speed up wound healing

Posted by in categories: biotech/medical, life extension

Stem cells are powerful tools that could one day unlock new frontiers in regenerative medicine. Now, a new study has shown that a certain type of stem cell can be delivered into injured tissues with dissolvable microneedles, to heal wounds.

Mesenchymal stem cells (MSCs) are responsible for replenishing bone, cartilage, muscle and fat cells in the body. But more recently, scientists have found that they have broader healing potential. If introduced to injured tissue, MSCs have been found to boost the formation of new blood vessels, reduce inflammation, and keep cells alive.

But there are a few problems. For one, injecting MSCs into the tissue with regular needles can cause further damage and scarring. Plus, it takes huge amounts of the cells to make sure that enough of them stick around to do their job.

Jun 9, 2020

Scientists Assert Electron Lifespan Is 5 Quintillion Times the Current Age of the Universe

Posted by in category: life extension

Circa 2015 o.o

Scientists didn’t actually see an electron decay, but they did manage to come up with some better numbers in relation to their longevity.

Jun 8, 2020

Drug researcher develops ‘fat burning’ molecule that has implications for treatment of obesity

Posted by in categories: biotech/medical, food, life extension

Mentions aging!

Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population. With obesity comes a variety of other interconnected diseases including cardiovascular disease, diabetes, and fatty liver disease, which makes the disease one of the most difficult—and most crucial—to treat.

“Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society,” said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.

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Jun 7, 2020

A look at Tesla battery degradation and replacement after 400,000 miles

Posted by in categories: life extension, sustainability

In this new installment of our series on the highest-mileage Tesla Model X (and one of the highest mileage EVs in the world), we look into battery degradation and replacement on a Tesla with over 400,000 miles.

Earlier this year, I bought one of the cheapest and most high-mileage Tesla Model X vehicles ever.

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Jun 7, 2020

Nanodevices track how cells change from inside

Posted by in categories: biotech/medical, life extension

This work on one-cell embryos could advance our knowledge of the mechanisms that underpin cellular behaviour in general, and may ultimately provide insights into what goes wrong in aging and disease.

For the first time, scientists have added microscopic tracking devices into the interior of cells, giving a peek into how development starts.

Jun 6, 2020

Rapamycin Fights Gum Disease and Spurs Bone Growth in Older Mice

Posted by in categories: biotech/medical, life extension

Rapamycin, a drug that has life-extending effects on mice (and possibly dogs and humans), also reverses age-related dental problems in mice. 🦷 Out now in eLife from researchers at The University of Washington School of Dentistry & JAX’s Kaczorowski Lab:

Rapamycin, which has life-extending effects on mice, also reverses age-related dental problems such as periodontitis and regrows bones in the animals.

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Jun 6, 2020

Chasing immortality | The Future is Now

Posted by in categories: biotech/medical, education, genetics, life extension, neuroscience

#Eternal life might not be attainable in the near future, but genetic engineers and doctors are working on new life extension technology. The research could lead to keeping our bodies young, and scientists are developing ways of downloading our brain’s consciousness onto digital media once the body is at the end of its life cycle.

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