Lifeboat Foundation

The most interesting part is a longevity escape velocity answer starting at 12:19 and going to 16:30.

Join Aubrey de Grey, Ph.D., Sergey Young, and Sourav Sinha as they talk about how our understanding of aging has developed in the last two decades. They will discuss:

Continue reading “SERGEY YOUNG — AMA #8: ‘Aging as an Engineering Problem’ with Aubrey de Grey” »

Fasting is one of those subjects that is widely talked about, in limited circles. Those who have looked cannot but be intrigued and impressed by the claims and results, whilst those who have not, think it borders on madness, and must be bad for you because…well, FOOD!!

So, for those who want a refresher on the science, through to those who have questions they have always been embarrassed to ask, and onwards to all those you want to send this link to, in an attempt to open their eyes…I did a quick guide to what we know, what are just finding out and at the end, the top questions that get asked on the topic.

Continue reading “Fasting Questions And Answers” »

Papers referenced in the video:

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population:
https://immunityageing.biomedcentral.com/articles/10.1186/s1…0126-7

Continue reading “C-Reactive Protein: What’s Optimal? A Comprehensive Review” »

With some unfortunate scifi examples.

What is it that gives meaning to your life? Is death necessary to give life meaning? Nicola is not quite convinced of that, and in this episode, he’ll tell you why along with why he’d like a longer life in good health instead.

Continue reading “Death, life, and meaning walk into a bar… — YouTube” »

Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published April 22 in PLOS Genetics.

In humans and other species with XY sex chromosomes, females often live longer than males. One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a “toxic y effect” that shortens males’ lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as females and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in toxic side effects.

The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in fruit flies have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging’s physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA’s toxic effects.

A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis.

A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice.

The study, published online April 22 in the journal Science, is the first randomized clinical trial to look at the metabolic effects of NMN administration in people.

Our ultimate goal is to improve regeneration of functional skin—and maybe other organs with the a similar endogenous mechanism.

University of Manchester scientists have cast new light on how our skin repairs itself, bringing the possibility of regeneration of the organ a step closer.

The study team, funded by the Medical Research Council and Helmut Horten Foundation, showed the activation of specific parts of the DNA leading to better division of human skin cells. The study is published in Nucleic Acid Research.

Continue reading “Scientists cast new understanding of how skin repairs itself” »

From a serendipitous meeting of minds to laser-enabled precision, Cellino is leveraging AI and pluripotent stem cells for longevity.

Telomeres are large nucleoproteins structures that cap the ends of chromosomes in eukaryotic cells. When a cell divides, a small portion of the telomere is lost due to the inherently incomplete process of genome replication. If left unchecked, over time the telomeres will reach a critically short length and the cell will face genomic instability, deterioration or death. To offset this shortening, an essential enzyme called telomerase rebuilds the telomeres by synthesizing new telomeric DNA repeats at chromosome ends. Kelly Nguyen’s group, in the LMB’s Structural Studies Division, has solved the first complete atomic model of this enzyme and discovered a histone dimer as novel telomerase subunits.

Telomeres act as a barrier to protect the genetic information from progressive degradation arising from incomplete DNA replication. Additionally, telomeres distinguish the natural chromosome ends from DNA double-strand breaks, thereby avoiding an illicit DNA damage response and preventing intrachromosomal fusion. This makes telomeres essential for the preservation of genome and chromosome stability. In previous research, Kelly had discovered the architecture and composition of human telomerase holoenzyme at 8 Å (Ångströms) resolution using cryo-EM. However, to understand the molecular mechanism governing telomerase mediated telomere maintenance, a high-resolution structure of the complex was required.

To conduct this study, Kelly’s group, in collaboration with Kathleen Collins at the University of California, Berkeley, and Rhiju Das at Stanford University, prepared telomerase by extracting it from cultured human cells, before imaging using cryo-EM—resulting in the collection of almost 44000 images. This data was analyzed using RELION—a complex computer program developed at the LMB—in order to achieve the 3.4−3.8 Å structure of telomerase. From this Kelly and members of her group, George Ghanim, Adam Fountain, and Marike van Roon, were able to build the first complete atomic model of telomerase, with 12 protein subunits and telomerase RNA. By completing the structure to such a high resolution, the group was not only able to illuminate how common RNA and protein motifs work together, but also to highlight new interactions.