Lifeboat Foundation

The researchers looked at multiple measures of cellular age. First, they used the epigenetic clock, where chemical tags throughout the genome indicate age. Secondly, they looked at the transcriptome, all the gene readouts produced by the cell. By these two measures, the reprogrammed cells matched the profile of cells that were 30 years younger, compared to reference data sets. In other words, cells from a woman of 53 now appeared like those of a woman aged 23.

The potential applications of this technique are dependent on cells not only appearing younger, but functioning like young cells too. Fibroblasts produce collagen – a molecule found in bones, skin tendons, and ligaments, helping provide structure to tissues and heal wounds. In this study, the rejuvenated fibroblasts produced more collagen proteins compared to control cells that did not undergo the reprogramming process. Fibroblasts also move into areas that need repairing. Researchers tested the partially rejuvenated cells by creating an artificial cut in a layer of cells in a dish, seen in the video below. The treated fibroblasts moved into the gap faster than older cells. This is a promising sign that one day this research could eventually be used to create cells that are better at healing wounds.

In the future, this research may also open up other therapeutic possibilities; the researchers observed that their method also influenced other genes linked to age-related diseases and symptoms. The APBA2 gene – associated with Alzheimer’s, and the MAF gene with a role in the development of cataracts – both showed changes towards youthful levels of transcription.

Researchers rejuvenate a 53-year-old woman’s skin by decades, but clinical applications are a way off.

With new death-defying technologies, radically extending life may soon be possible.

In a new trial conducted by the University of Cambridge, scientists were successfully able to de-age human skin cells by 30 years.

With age, the ability of cells to function properly declines. As a result, the NDA blueprint of people starts to accumulate signs of aging.

Researchers have used regenerative biology to create ‘’induced’’ stem cells and produce fibroblasts that generates collagens that heal wounds and provide structure to tissues.

A team of researchers have found a way to “time jump” cells back 30 years. A team of researchers at the Babraham Institute, a partner organization of the University of Cambridge, UK, have made a breakthrough in regenerative medicine. Just published in the journal eLife, the team shows how they managed to turn back the clock 30 years for human skin cells.

A new regenerative medicine technique has been developed that can make old human cells 30 years younger without losing specialization.

Dr Fossel talking about dementia, telomeres, and clarifying some experimental myths.

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Continue reading “Michael Fossel | Aging: Understanding it, Reversing it” »

Humans could live until the ripe old age of 150 years according to recent research – and scientists are racing to work out how.

Harvard geniuses, biohackers and internet billionaires are all looking for ways that humans can crack the code on aging.

WaitButWhy blogger Tim Urban writes “the human body seems programmed to shut itself down somewhere around the century mark, if it hasn’t already”.

Through experimentation with a highly promising anti-aging technique, scientists at the UK’s Babraham Institute have demonstrated a new way of turning back the clock in human skin cells. These cells functioned like cells 30 years younger, but in what represents an exciting advance in the field, were able to still retain some of their specialized functions acquired through age.

In 2012, Japanese researcher Shinya Yamanaka earned a Nobel Prize for his work in developing what are known as induced pluripotent stem cells (iPSCs). These start out as regular adult tissue cells that are harvested and exposed to four molecules called Yamanaka factors, which return them to an immature state. From here, the stem cells can theoretically develop into any cell type in the body.

We’ve seen scientists explore this potential in a number of exciting ways, implanting them in rabbits to restore vision, addressing dopamine deficiencies in animal models of Parkinson’s disease and repairing damaged heart muscles in pigs. The full reprogramming process involves subjecting the cells to the Yamanaka factors for around 50 days, but the Babraham scientists have found that shortening this process might bring some significant benefits to the table.

Findings could lead to targeted approach for treating aging.

Research from the Babraham Institute has developed a method to ‘time jump’ human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today (April 7, 2022) in the journal eLife and whilst at an early stage of exploration, it could revolutionize regenerative medicine.

Continue reading “‘Time Jump’ by 30 Years: Old Skins Cells Reprogrammed To Regain Youthful Function” »