Lifeboat Foundation

“Deep in the forests of Germany, nestled neatly into the hollowed-out shells of acorns, live a smattering of ants who have stumbled upon a fountain of youth. They are born workers, but do not do much work. Their days are spent lollygagging about the nest, where their siblings shower them with gifts of food. They seem to elude the ravages of old age, retaining a durably adolescent physique, their outer shells soft and their hue distinctively tawny. Their scent, too, seems to shift, wafting out an alluring perfume that endears them to others. While their sisters, who have nearly identical genomes, perish within months of being born, these death-defying insects live on for years and years and years,” Katherine J. Wu writes.

A parasite gives its hosts the appearance of youth, and an unmatched social power in the colony.

Zoledronate is a biophosphonate, a drug used to strengthen bones and reduce the risk of osteoporosis-related bone fractures. It is well-absorbed into the bones, so it only needs to be administered through infusion once a year.

A 2010 study had found that people who were given zoledronate after experiencing hip fractures showed slightly reduced all-cause mortality compared to a control group. Patients who took the drug were at significantly lower risk for heart arrhythmias and pneumonia.

As this is a drug that is already being given to people, the choice to go back to genetically modified fruit flies, a much simpler model of aging, may seem counterintuitive. The team chose to test these insects for two principal reasons. The first is that Drosophila flies are a common subject of studies on basic aging pathways, which the researchers wished to explore. The second is simpler: Drosophila flies lack bones, making the bone-affecting properties of zoledronate irrelevant to the study.

The Retrobiome, Cancer, And Aging — Roswell Park Comprehensive Cancer CtrThe Retrobiome, Cancer, And Aging — Dr. Andrei Gudkov, PhD, DSci, Roswell Park Comprehensive Cancer Center, joins me on Progress, Potential, And Possibilities Cornell University College of Veterinary Medicine #Cancer #Vaika #Genome #DnaDamage #ImmunoSenescence #Pets #Dogs #Health #Lifespan #LifeExtension #Inflammaging #Longevity #Aging #Oncology

Dr Andrei Gudkov, PhD, DSci, is a preeminent cancer researcher who serves as Senior Vice President, Research Technology and Innovation, Chair of the Department of Cell Stress Biology, and a member of the senior leadership team for National Cancer Institute (NCI) Cancer Center Support Grant at Roswell Park Comprehensive Cancer Center (https://www.roswellpark.org/andrei-gudkov).

Continue reading “Dr. Andrei Gudkov, PhD — The Retrobiome, Cancer, And Aging — Roswell Park Comprehensive Cancer Ctr” »

Paper referenced in the video:

Can human aging be postponed?
https://pubmed.ncbi.nlm.nih.gov/10614072/

Continue reading “100% Lifespan Extension In Drosophila: A Conversation With Dr. Michael Rose” »

Possibilities.

Summary: Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.

Source: IST Austria

Continue reading “Rejuvenating Mouse Brains With Ketamine or Flickering Light” »

It’s an astonishing achievement — and in an eyebrow-raising twist, Simons says he plans to live forever, by turning himself into a cyborg.

It sounds like Simons has thought out his plan.

“This is the first puzzle piece in my goal of replacing body parts with mechanical parts,” Simons told De Telegraaf, adding that his goal is “immortality.”

Long vid. Slight annotation in the comments. A few takaways I liked: We need to move to human data instead of mice. People’s attitude towards life extension should change drastically soon. There is human data among this group and have released it, will keep following it, and some to be released soon. Sinclair thinks he can start primate trials this year. And overall everyone is optimistic.

A couple of weeks ago Avi Roy, alongside Nathan Cheng & Laura Minquini, hosted the Longevity Panel discussion, which assembled some of the biggest scientists in the field currently working on reversing aging.

Continue reading “Longevity Panel — The Scientists working on Reversing Aging | Part 1” »

Researchers and entrepreneurs are starting to ponder how AI could create versions of people after their deaths—not only as static replicas but as evolving digital entities that may steer companies or influence world events.

Experts are exploring ways artificial intelligence might confer a kind of digital immortality, preserving the personalities of the departed in virtual form and then allowing them to evolve.

The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.

In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU

Continue reading “Translating Blood Plasma Dilution To Humans | Drs. Irina & Mike Conboy Interrview Series Ep3” »