Lifeboat Foundation

As we age, our muscles gradually become smaller, weaker and less able to heal after injury. In a new study, UPMC and University of Pittsburgh researchers pinpoint an important mediator of youthfulness in mouse muscle, a discovery that could advance muscle regeneration therapies for older people.

Published today in Nature Aging, the study demonstrates that circulating shuttles called extracellular vesicles, or EVs, deliver genetic instructions for the longevity protein known as Klotho to muscle cells. Loss of muscle function and impaired muscle repair in old mice may be driven by aged EVs, which carry fewer copies of these instructions than those in young animals.

The findings are an important advance in understanding why the capacity for muscles to regenerate dwindles with age.

Dubbed an ‘intelligent bomb,’ this biotechnology marks an advance in senolytics, which aims to remove harmful, zombie-like cells from the body.

In addition to our film, Gitcoin is also hosting several different longevity projects via Lifespan.io / Lifespan Extension Advocacy Foundation, all of which you can support by clicking below 🧬

Projects put forth by the Lifespan Extension Advocacy Foundation (LEAF) — aka Lifespan.io — and projects fiscally sponsored by LEAF.

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

The team, led by Professor Luc Mongeau and Assistant Professor Jianyu Li, developed a new injectable hydrogel for wound repair. The hydrogel is a type of biomaterial that provides room for cells to live and grow. Once injected into the body, the biomaterial forms a stable, porous structure allowing live cells to grow or pass through to repair the injured organs.

https://www.cryonics.org/images/uploads/magazines/CI_NEWS-2021-03.pdf

Due to last years success, I am back with an updated list of my 5 most promising anti-aging compounds.

There are more than 200 different geroprotective compounds. Some of these are already available as supplements, some are in clinical trials and some have FDA approval. Which are my top 5 that I think i most promising in terms of their anti-aging effects (so focusing more on healthspan than lifespan). And note the use of “promising” — there is still much work to be done to better investigate the long-term safety, dose and timings of different supplements which you should always bear in mind.

Continue reading “5 Most Promising Anti-Aging Compounds (Updated 2022)” »

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

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Papers referenced int the video:
Joint distribution of lipoprotein cholesterol classes. The Framingham study.
https://pubmed.ncbi.nlm.nih.gov/6573877/

Continue reading “How Many Calories Are Optimal For Health?” »

Engie and Macquarie to build 150MW one hour battery at site of shuttered Hazelwood coal generator.

French energy giant Engie and Macquarie’s Green Investment Group are to jointly fund the construction of a 150MW/150MWh big battery at the site of the now closed Hazelwood brown coal generator.

The announcement, which comes four years after Engie closed what was Australia’s dirtiest power station, continues the trend of using the sites of closed or ageing coal and gas plants to build battery storage to support the switch to 100 per cent renewables.

Continue reading “Engie and Macquarie to fund 150MW big battery at Hazelwood” »