Lifeboat Foundation

Delaying, Detecting, Preventing and Treating Aging And Associated Diseases — Dr. Brian Kennedy, Ph.D., National University of Singapore.

Dr. Brian Kennedy is Distinguished Professor, Department of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Director of National University Health System (NUHS) Centre for Healthy Ageing, Singapore, Professor, Buck Institute for Research on Ageing, Adjunct Professor, Leonard Davis School of Gerontology, USC, and Affiliate Faculty, Department of Biochemistry, University of Washington.

Continue reading “Dr. Brian Kennedy Ph.D. — Delaying, Detecting, Preventing and Treating Aging And Associated Diseases” »

You hear so much about the wonders of coffee, that I decided it was time to even the score.

Tea Is Fantastic.

Continue reading “Tea Is Fantastic — Let’s Hear It For The Humble Cuppa” »

If we look at the mortality tables, it can explain why reversing aging damage reversal has to work very well for people to live very long lives.

Let us imagine that we are able to reverse aging damage so that someone is 65 or older has the same amount of aging as someone who is 65. This means for an average American man, then half of those people will still be dead by the time they have reached 95 years of age. This is because 1.6% of them are dying every year in the 65-year-old condition. Also, only 80% of them have survived from birth to the age of 65.

Asian American women in New Jersey live to a life expectancy of 93. Half of them reach the age of 93. Antiaging that reverses the aging damage every year for men so that they never get worse physically than when they are 65, get them to a life expectancy that is just beyond what Asian American women in New Jersey already achieve.

Click the actual scientific article link within for more details on the research.

In their research a number of genes that are different between pathological aging and healthy aging. Their findings were published in the scientific journal Aging.

Here’s my latest video (audio issues fixed!):

Papers referenced in the video:

Continue reading “Gut Bacteria Boost Host NAD Metabolism” »

Extract from a conversation that María Blasco, Director of the Spanish National Cancer Research Center (CNIO for its acronym in Spanish) had with Mario Alonso Puig during the celebration of the South Summit 2020.

In this segment María Blasco refers to aging, cancer, telomerase, and life extension. The conversation is in English and I added subtitles in Spanish.

Continue reading “Dr. María Blasco refers to Telomerase and Life Extension (in English with S/T en Español)” »

Bees, termites, and ants can teach us a lot about cooperation, communication, and the skills that keep societies together. But these so-called social insects may also hold secrets that could reshape our understanding of human aging. Many social insects exhibit surprising aging characteristics that cause their life spans to shift depending on their roles. Following the death of a queen Indian jumping ant, for example, workers fight for the right to transform into an egg-laying ant. Much is at stake: the life expectancy of an egg-layer is five times longer than that of a worker’s. Though fruit flies, mice, and nematodes currently dominate aging research, some scientists say social insects’ aging behaviors could help dissect aging mechanisms in humans. This video will take you deep into the catacombs—er, honeycombs—of insect aging.

Read the story ($): https://scim.ag/3cFO0k0

Dr Joan Mannick, Head of Research and Development at Life Biosciences, discusses the #geroscience approach in disease treatment and the exciting work being done at Life Biosciences.

#Ageing is the greatest risk factor for almost every chronic disease. Multiple studies have shown that ageing is a modifiable risk factor that can be targeted therapeutically.

Continue reading “Targeting the biology of ageing to prevent, treat and reverse age-related diseases | Dr Joan Mannick” »

Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. The discovery is expected to play a major role in efforts to develop treatments that would battle a myriad of chronic age-related conditions that range from arthritis to lung disease to Alzheimer’s disease and glaucoma. This biomarker is a unique signaling lipid metabolite, normally exclusively intracellular, but is released when senescent cells are forced to die. This metabolite is detectible in blood and urine, making non-invasive testing possible. With a growing list of senolytic drugs in development, detecting this metabolite via a companion test could verify performance of senolytic candidates.

“The list of age-related diseases definitively linked to cellular senescence keeps growing, as does the number of biotech companies racing to develop drugs to eliminate senescent cells,” said Buck professor Judith Campisi, Ph.D., senior scientist on the study. “While the field has never been more promising, the lack of a simple biomarker to measure and track efficacy of these treatments has been a hindrance to progress. We are excited to bring this new biomarker to the field and look forward to it being used in the clinic.”