Lifeboat Foundation

(THE CONVERSATION) Racism steals time from people’s lives – possibly because of the space it occupies in the mind.

Question Is racial discrimination associated with brain connectivity, and are alterations in deep brain functional connectivity associated with accelerated epigenetic aging?

Findings In this cohort study of 90 Black women in the US, higher self-reported racial discrimination was associated with greater resting-state functional connectivity (RSFC) between the locus coeruleus (LC) and precuneus. Significant indirect effects were observed for the association between racial discrimination frequency and DNA methylation age acceleration.

Continue reading “Racial Discrimination, Neural Connectivity, and Epigenetic Aging in Black Women” »

Sorry, lol, i had to.

‘I’m never going to age’

It’s a crucial support to most everything our body does. When we’re young, our body is efficient at producing NAD.

Continue reading “Forget Ozempic. Celebrities are all in on taking a new anti-aging drug” »

A group of scientists has devised a plan to safeguard Earth’s species in a cryogenic biorepository on the moon.

Intended to save species in the event of a disaster on Earth, the plan makes use of craters that are permanently in shadow and therefore cold enough to allow cryogenic preservation of biological material without using electricity or liquid nitrogen, according to research from a group led by scientists at the Smithsonian, published last week.

The paper, published in the journal BioScience, draws on the successful cryopreservation of skin samples from a fish, and outlines a method for creating a biorepository that would keep samples of other species safe.

An antibody treatment designed to revitalize an aging immune system delivers “surprising” results in elderly mice.

Aging is associated with blood flow changes in the brain.

These changes may be linked to an increased risk of neurodegenerative conditions.

Researchers have mapped the aging processes of blood vessels in the brains of mice in an effort to establish how they affect cognitive decline.

Continue reading “How do aging brain blood vessels contribute to cognitive decline?” »

The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet so far, most of these clocks have been developed from heterogeneous bulk tissues, and are thus composites of two aging processes, one reflecting the change of cell-type composition with age and another reflecting the aging of individual cell-types. There is thus a need to dissect and quantify these two components of epigenetic clocks, and to develop epigenetic clocks that can yield biological age estimates at cell-type resolution. Here we demonstrate that in blood and brain, approximately 35% of an epigenetic clock’s accuracy is driven by underlying shifts in lymphocyte and neuronal subsets, respectively. Using brain and liver tissue as prototypes, we build and validate neuron and hepatocyte specific DNA methylation clocks, and demonstrate that these cell-type specific clocks yield improved estimates of chronological age in the corresponding cell and tissue-types. We find that neuron and glia specific clocks display biological age acceleration in Alzheimer’s Disease with the effect being strongest for glia in the temporal lobe. The hepatocyte clock is found accelerated in liver under various pathological conditions. In contrast, non-cell-type specific clocks do not display biological age-acceleration, or only do so more marginally. In summary, this work highlights the importance of dissecting epigenetic clocks and quantifying biological age at cell-type resolution.

The authors have declared no competing interest.

The Illumina DNA methylation datasets analyzed here are all freely available from GEO (www.ncbi.nlm.nih.gov/geo).

Telomerase gene therapy shows promising potential for treating pulmonary fibrosis and other diseases associated with short telomeres.

Continue reading “Telomerase gene therapy shows promising potential for treating pulmonary fibrosis” »

There’s only one alliterative phrase i like more than ‘the sheekey science show’, and that’s ‘anti-aging antibodies’. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper — immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month — Inhibition of IL-11 signalling extends mammalian healthspan.

Find me on Twitter — / eleanorsheekey.

Continue reading “Anti-Aging Antibodies?” »

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