Lifeboat Foundation

Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Keywords: hyaluronic acid, hyaluronic acid synthases, hyaluronidases, CD44, RHAMM, skin aging.

Human skin aging is a complex biological process, not yet fully understood. It is the result of two biologically independent processes. The first is intrinsic or innate aging, an unpreventable process, which affects the skin in the same pattern as it affects all internal organs. The second is extrinsic aging, which is the result of exposure to external factors, mainly ultraviolet (UV) irradiation, that is also referred to as photoaging.¹ Intrinsic skin aging is influenced by hormonal changes that occur with age,² such as the gradual decreased production of sex hormones from the mid-twenties and the diminution of estrogens and progesterone associated with menopause. It is well established that the deficiency in estrogens and androgens results in collagen degradation, dryness, loss of elasticity, epidermal atrophy and wrinkling of the skin.³

A clinical-stage leader in immune-stimulatory vaccines for cancer announced the publication of its favorable long-term Overall Survival (OS) data from a Phase I trial evaluating a universal cancer vaccine candidate, UV1, in combination with checkpoint inhibitor ipilimumab, in patients with metastatic malignant melanoma.

UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.

Published in the Frontiers in Immunology journal on May 11, 2021, Norway-based Ultimovacs ASA’s UV1 vaccine candidate achieved the primary endpoints of safety and tolerability.

Not sure how novel.

People who live beyond 105 years are more efficient at repairing DNA, according to a study published today in eLife.

Paolo Garagnani and colleagues, in collaboration with several research groups in Italy and a research team led by Patrick Descombes at Nestlé Research in Lausanne, Switzerland, recruited 81 semi-supercentenarians (those aged 105 years or older) and supercentenarians (those aged 110 years or older) from across the Italian peninsula. They compared these with 36 healthy people matched from the same region who were an average age of 68 years old.

Continue reading “People Who Live Beyond 105 Have Better DNA Repair” »

Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct—or senescent—cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.

In a healthy state, these immune cells —known as invariant Natural Killer T (iNKT) cells—function as a surveillance system, eliminating cells the body senses as foreign, including senescent cells, which have irreparable DNA damage. But the iNKT cells become less active with age and other factors like obesity that contribute to chronic disease.

Finding ways to stimulate this natural surveillance system offers an alternative to senolytic therapies, which to date have been the primary approach to removing senescent cells. It could be a boon to a field that has struggled with how to systemically administer these senolytics without serious side effects.

We’ve updated our list of top longevity conferences and events for 2021, adding 4 new ones and removing 3 that are no longer happening:

Update 5/10/2021: This post has been updated since we originally published it in August 2020. Several new longevity conferences have been added and several which are no longer happening have been removed.

Continue reading “17 Best Longevity Conferences and Events for 2021” »

7:01 they talk about Church’s comments of ending aging by 2030. Also this appears to be a part one.

In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.

Continue reading “My Theory & The Future Of Aging | Prof George Church Interview Series Episode 1” »

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway:
https://pubmed.ncbi.nlm.nih.gov/32130883/

Continue reading “Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation” »

Excerpts from an interview with Dr. María Blasco, Director of the Spanish National Cancer Research Center (CNIO), where she covers how telomeres shortening induce aging, how artificially lenghtening telomeres has proven to extend lifespan in animal models like mice, and what the impact will be in human health and lifespan once the techniques (gene therapies) get effectively translated into humans.

The interview took place on May 6, 2021 as part of a program organized by the Madrid Planetarium, to contribute to a better orientation of the students of the last years of high school when deciding which university studies further engage.

Continue reading “María Blasco sobre retrasar el envejecimiento y extender la vida (with S/T in English)” »

https://www.youtube.com/watch?v=UudjpTgB3K8&feature=share

0:00 — Title.
0:35 — Into.
1:15 — Super People of The Future.
1:46 — Neal VanDeree ‘Living Long Healthy Lives Will be Possible’ — https://www.churchofperpetuallife.org/ — https://www.youtube.com/user/COPL18
3:24 — Dr. Bill Andrews ‘Super Wonderful Future’ — https://www.sierrasci.com/
6:27 — Selim Bakırcı ‘1000 years long life’
6:58 — Rodrigo Guinea ‘Great Responsibility’ — https://www.linkedin.com/in/rodguinea/
9:22 — Significant Research.
9:40 — Significant Research — Liz Parrish — https://bioviva-science.com/
10:44 — Significant Research — Brent Nally — https://longevityplan.net/ — https://www.linkedin.com/in/brentnally/ — https://www.youtube.com/user/BrentAltonNally.
13:10 — Significant Research — Cain Hillier — https://www.linkedin.com/in/cain-hillier-50571a18a/
14:43 — Significant Research — Chris Curwen — https://www.linkedin.com/in/chris-curwen-67144b169/
17:16 — The Threshold Times.
18:41 — The Threshold Times — Brent Nally.
21:35 — The Threshold Times — Chris Curwen
24:25 — The Threshold Times — Liz Parrish.
26:21 — The Threshold Times — Nicolas Chernavsky
https://www.linkedin.com/in/nicolas-chernavsky-25265835/ — https://www.youtube.com/channel/UCUASjdn96BRlGVytmbDgRRA
27:00 — The Threshold Times — Josh Martin.
27:42 — The Threshold Times — Cain Hillier.
28:50 — The Threshold Times — Vikram Pandya — https://www.linkedin.com/in/vikrampandya/
31:24 — Ageing Is a Disease.
32:49 — Ageing Is a Disease — Neal VanDeree.
34:09 — Ageing Is a Disease — Dr. Bill Andrews.
37:48 — Ageing Is a Disease — Liz Parrish.
39:28 — Ageing Is a Disease — Brent Nally.
42:10 — Ageing Is a Disease — Aaron King.
44:44 — Ageing Is a Disease — Lukas Vismantas — https://www.linkedin.com/in/lukas-vismantas/?originalSubdomain=dk.
46:07 — Ageing Is a Disease — Cain Hillier.
48:02 — Ageing Is a Disease — Chris Curwen.
50:23 — Ageing Is a Disease — Nicolas Chernavsky.
52:49 — The Big Times.
54:40 — The Big Times — Dr. Bill Andrews.
56:52 — The Big Times — Liz Parrish.
59:16 — The Big Times — Brent Nally.
01:03:50 — The Big Times — Nicholas Mohnacky — https://www.bundleiq.com/ — https://www.linkedin.com/in/mohnacky/
01:05:00 — The Big Times — Bolek Kerous — https://www.linkedin.com/in/bolekkerous/ — https://www.youtube.com/channel/UCSpv8MA3xPskco9qdIBeNuQ
01:08:24 — The Big Times — Nicolas Chernavsky.
01:08:58 — The Big Times — Chris Curwen.
01:09:48 — The Big Times — Nicolas Chernavsky.
01:11:19 — The Big Times — Jeremy Rumble — https://www.linkedin.com/in/jeremy-rumble-42910b38/
01:12:22 — The Big Times — Jakub Czubak — https://www.linkedin.com/in/jakub-czubak-603624a9/
01:14:20 — The Big Times — Josh Martin.
01:14:50 — The Big Times — Nicolas Chernavsky.
01:20:15 — The Big Times — Brent Nally.
01:22:09 — Ending.

Omitting natural disasters like an asteroid smashing Earth or a volcano eruption we can say that improving human health and condition is the most important safety case/concern and the fundamental thing to consider and accomplish on our way to be super cosmic humanity. Significant health improvements will free us from all diseases, allow us to develop superhuman intelligence, let us totally self-realize, and consequently, help realize the infinity in the matter for the common good. However intensively we focus on intelligence, it is not possible to experience its natural consequence or the next level of its advancement/evolution if there is no good health. Coherent and consistent collective mind continuum experience is not possible without super health (Healthy life that is free from the danger of uncontrollable death). Our bodies are short-timed and not strong enough to hold up the Earth-Gravity-Geometry sized/adjusted thoughts that are necessary to naturally manage and effectively inhabit our planet.

Continue reading “Super Long HealthSpans: In The Making” »