Lifeboat Foundation

Aging research fans might like.

“In their work, Hamiliton’s team found that the Dunkin Hartley guinea pig was a good candidate for a muscle aging model due to the animal’s tendency to develop osteoarthritis (OA) at a young age.”

There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body—the musculoskeletal system that includes muscles, bones, tendons and cartilage—age-associated decline is inevitable, and the rate of that decline increases the older we get. The loss of muscle function—and often muscle mass—is scientifically known as sarcopenia or dynapenia.

Continue reading “Researchers identify promising model for studying human aging” »

Annotated!

Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics.
Feel free to ask any related questions that you want Aubrey to try and answer!

Continue reading “Aubrey de Grey Longevity Q&A — The last 25 years, SENS, Longevity Escape Velocity, & More” »

UC San Francisco scientists have discovered a new way to control the immune system’s “natural killer” (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The findings could also be used to enhance the ability of cancer immunotherapies to detect and destroy lurking tumors.

The study, published today (January 82021) in the Journal of Experimental Medicine, addresses a major challenge for the field of regenerative medicine, said lead author Tobias Deuse, MD, the Julien I.E. Hoffman, MD, Endowed Chair in Cardiac Surgery in the UCSF Department of Surgery.

“As a cardiac surgeon, I would love to put myself out of business by being able to implant healthy cardiac cells to repair heart disease,” said Deuse, who is interim chair and director of minimally invasive cardiac surgery in the Division of Adult Cardiothoracic Surgery. “And there are tremendous hopes to one day have the ability to implant insulin-producing cells in patients with diabetes or to inject cancer patients with immune cells engineered to seek and destroy tumors. The major obstacle is how to do this in a way that avoids immediate rejection by the immune system.”

Aging is, at least for now, inevitable, and our eyes are not immune to those changes. Vision loss is, in fact, one of the top 10 causes of disability in the US., however, shows that this might be reversible in the future.

A large team of geneticists, ophthalmologists, and other scientists used a group of molecules called Yamanaka factors to turn cells in the eyes of mature mice back to a youthful state. This reversed the damage done by aging, and the cells were then able to regenerate, connect back to the brain, and vision was restored in both models of normal aging and glaucoma.

Continue reading “Scientists have restored youth to aging eyes in mice” »

Watch out, George Lucas, there’s a new attack of the clones, and these ones are furry.

Japanese researchers have created a potentially endless line of mice cloned from other cloned mice. They used the same technique that created Dolly the sheep to produce 581 mice from an original donor mouse through 25 rounds of cloning, the scientists report in the March 7 issue of the journal Cell Stem Cell.

“This technique could be very useful for the large-scale production of superior-quality animals, for farming or conservation purposes,” study leader Teruhiko Wakayama of the RIKEN Center for Developmental Biology in Kobe, Japan, said in a statement.

CRISPR gene editing in mice has been used to correct a mutation that can cause rapid ageing, dramatically improving the animals’ health and lifespan.

Moonshot Thinking For Aging, Mental Health, And Drug Re-Purposing — Dr. Tim R. Peterson.

Washington University in St. Louis.

Continue reading “Dr. Tim R. Peterson — Moonshot Thinking For Aging, Mental Health, And Drug Re-Purposing” »

We tried to be comprehensive here, but are there any big arguments against life extension (ethical or otherwise) that you always hear that we missed?

Thinking through the ethics of life extension can be complicated. Here are the main pros and cons of immortality from an ethical standpoint.

Gene therapies are opening up possibilities that were once reserved for science fiction.

At Harvard University, Professor of Genetics David Sinclair says he believes it’s possible to unlock the fountain of youth, and gene therapy is the key.

Continue reading “Gene Therapies and the Promise of the Fountain of Youth” »