Lifeboat Foundation

Boosting brain function is key to staving off the effects of aging. And if there was one thing every person should consider doing right now to keep their brain young, it is to add extra virgin olive oil (EVOO) to their diet, according to research by scientists at the Lewis Katz School of Medicine at Temple University (LKSOM). EVOO is a superfood, rich in cell-protecting antioxidants and known for its multiple health benefits, including helping put the brakes on diseases linked to aging, most notably cardiovascular disease. Previous LKSOM research on mice also showed that EVOO preserves memory and protects the brain against Alzheimer’s disease.

In a new study in mice published online in the journal Aging Cell, LKSOM scientists show that yet another group of aging-related diseases can be added to that list—tauopathies, which are characterized by the gradual buildup of an abnormal form of a protein called tau in the brain. This process leads to a decline in mental function, or dementia. The findings are the first to suggest that EVOO can defend against a specific type of mental decline linked to tauopathy known as frontotemporal dementia.

Alzheimer’s disease is itself one form of dementia. It primarily affects the hippocampus—the memory storage center in the brain. Frontotemporal dementia affects the areas of the brain near the forehead and ears. Symptoms typically emerge between ages 40 and 65 and include changes in personality and behavior, difficulties with language and writing, and eventual deterioration of memory and ability to learn from prior experience.

Last July, the Life Extension Advocacy Foundation hosted a great conference on rejuvenation biotechnology in New York City; if you missed it, this episode of X10 will fill you in on some of the best talks of the conference.

Full playlist of all talks: https://bit.ly/2pP2BE6

NOTE FROM TED: This talk, which was filmed at a TEDx event, contains several assertions about diet that come from the speaker’s own understanding of nutrition. While some viewers may find advice provided in this talk to be helpful, please do not look to this talk for medical advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf

Can you cure your self from life threatening health problems? Can you reverse ageing? Darryl D’Souza, an expert in natural therapy and pioneer in integrated wellness and spirituality talks about how he reversed ageing by following simple laws of nature about food and nutrition. How the food that we eat today has become our poison and how we can reclaim our lives and good health. Darryl is the author of “Become Healthy or Extinct”, a book about reversing chronic illnesses with integrated natural therapy. The book has followers in over 150 countries. An engineer by profession, but drawn into the world of natural therapies after failed attempts by modern medicine to cure him of some serious illnesses at a young age. Darryl is a pioneer in Integrated Wellness & Spirituality and conducts life-transforming talks & workshops that expose the real causes of widespread sickness in society and he gives you breakthrough ideas on how to become part of the solution instead of being part of the problem. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases. The findings were published in the journal Molecular Cell.

Cells have a natural ability to routinely rid themselves of unnecessary or dysfunctional proteins and organelles. During this process of “autophagy,” debris are tagged with a compound called ubiquitin and then degraded within tiny cellular vacuoles. Autophagy is impaired in some cancers, and neurodegenerative and metabolic diseases, so scientists have been working to develop drugs that can regulate this process. However, little is known about the details of autophagy, such as how the cell knows which components to tag with ubiquitin.

In previous research, Hirokazu Arimoto, a chemical biologist at Tohoku University, and colleagues found that autophagy is initiated against invading streptococci bacteria when they are tagged with the nucleic acid guanine. The researchers wondered if guanine tagging could also initiate autophagy against other cellular components.

Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment.

Patient-paid trial likely to cause backlash

The topic of patient-paid trials often stirs up considerable debate among the research community, regulatory authorities, and the general public, with many people suggesting that it is unethical to expect patients to pay to participate in clinical trials. While this is a controversial issue, these trials are a legitimate way to test therapies that would otherwise struggle to reach the clinic due to cost constraints, and the data gathered by such trials can still be valuable.

The study saw the deployment of a multiple target gene therapy focused on 3 known longevity genes delivered via an adeno-associated virus. The focus was on mitigating T2 diabetes, heart failure, and kidney failure in mouse models with very positive results observed. Join us on Tuesday, 26th November, 1pm EDT on our Facebook page for the livestream show.

Just one million dollars.

MANHATTAN, Kan., Nov. 21, 2019 /PRNewswire/ — Libella Gene Therapeutics, LLC (“Libella”) announces an institutional review board (IRB)-approved pay-to-play clinical trial in Colombia ( South America ) using gene therapy that aims to treat and ultimately cure aging. This could lead to Libella offering the world’s only treatment to cure and reverse aging by 20 years.

A team of scientists at the University of Antwerp (Belgium) wants to stop the aging process. They are fascinated by uncovering longevity signatures at the tiny molecular level and are developing an intelligent nanomachine that lays the foundations for new therapies against aging and chronic diseases. Only ten conditions cause 75% of all mortalities. The top three of cardiovascular disease, diabetes, and cancer accounts for 50% of all mortalities. Are these chronic diseases age-related? Can we address them by targeting aging?

A new study finds that gut bacteria from old mice can help rejuvenate the neurons of younger ones, suggesting that gut bacteria are key to aging.