Jun 20, 2024
Targeted Covalent Inhibition of Telomerase
Posted by Quinn Sena in categories: biotech/medical, life extension
I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell.
Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in ∼90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves noncanonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.