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Category: life extension – Page 364


James W. Clement is a longevity researcher who was the 12th person on the planet to have his DNA sequenced. In 2010 James launched his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School. Since then Clement has read 20,000 medical research papers on longevity and has acquired one of the largest DNA databases of supercentenarians, the youngest of whom is 106 years old. Most recently James W. Clement is the author of the Switch: Ignite your metabolism with intermittent fasting, protein cycling, and keto. Finally, I know James personally and have gone to visit his previous research lab in Apple Valley, California, so I can honestly say that he is among the most humble humans and the hardest-working longevity researchers that I have ever seen. I have learned a lot from Clement and I hope you do too.

During this 2 hour interview with James W. Clement, we cover a variety of interesting topics such as: Clement’s journey from being a lawyer to becoming a full-time longevity researcher; the name and story behind Better Humans; why James is a transhumanist; why we have to first make it to 100 before we start taking “magic pills”; the switch between mTOR and autophagy; the importance of intermittent fasting, its time and duration; the connection between gut bacteria and dopamine; why the biggest problem of our diet is the overconsumption of both dairy and meat; protein cycling and why we can’t sustain autophagy indefinitely; the dangers of coconut oil; why all centenarian blue zones in the world eat high-carb diets and why we should try keto.

My favorite quote that I will take away from this interview with James W. Clement is:

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PepsiCo’s Senior VP of R&D, Dr. Ellen de Brabander, joins me on this ideaXme (http://radioideaxme.com/) episode to talk about running the R&D engine for a $200 billion company, the parallels between pharma and food in terms of increasing customization / personalization, and her future visions for the $8 trillion global food and beverage space — (Personal caveat — While I avoid processed foods, one cannot ignore the place at the table that “big food” will have in crafting and investing in the future of health, wellness, and longevity) — https://www.youtube.com/watch?v=tDSiVlKNnRA&t=1 #Ideaxme #Pepsi #Nutrition #Research #Science #Health #Wellness #Sustainablity #Longevity #FritoLay #Tropicana #QuakerOats #Gatorade #Aquafina #MountainDew #Doritos #Cheetos #Ruffles #Tostitos #Fritos #Biotech #LifeExtension #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Ellen de Brabander, Senior Vice President Research and Development at PepsiCo.

Ira Pastor Comments:

Today we are going to segue into the food industry, which is a fascinatingly complex and diverse set of businesses that supplies most of the food consumed by the global population.

In 2020, food, needless to say, is much more than just calories.

Continue reading “PepsiCo: The Future Of Food” | >

Dr. Theodore Ho talks about the rapidly expanding possibilities of stem cells to be used in reversing or slowing the aging process. He discusses his previous and current work with the brain, including such methods as tissue clearing, multifiber photometry and optogenetics, and single resolution calcium imaging and control. Dr. Ho is a neuroscientist and stem cell biologist studying the mechanisms and causes of biological aging and potential strategies to slow or reverse them, in order to prevent the onset of age

Associated diseases to help us live healthier and longer lives.

He completed a four-year joint bachelor’s/master’s degree program in.

Human developmental and regenerative biology/bioengineering at.

Harvard University, and he received his PhD in Biophysics from the.

University of California San Francisco, studying stem cell aging in the lab of Dr. Emmanuelle Passegue. In college he developed a nanoparticle drug delivery system, in graduate school he discovered previously unknown mechanisms of cellular and molecular aging of stem cells, and now in the Deisseroth lab he is using optical recording and perturbation of neuronal activity to study neural circuit dynamics that control behavior. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Continue reading “Aging and Stem Cells | Theodore Ho | TEDxMiddlebury” | >

Acarbose and Metformin are commonly used to treat type 2 diabetes, but now they are also being tested for anti-aging effects, and according to the researchers these two FDA approved drugs have big promise.

In mice testing Acarbose and Metformin were demonstrated to increase health, lifespan, and longevity of the animals. These two drugs are now being tested in monkeys that have a similar physiology, reproductive system, and aging pattern as humans, in research being conducted at Texas Biomedical Research Institute which is supported by a pilot grant provided by the San Antonio Claude D. Pepper Older Americans Independence Center.

“I think this type of research can change what life is like for geriatric people,” said Corinna Ross, Ph.D, Associate Professor, Southwest National Primate Research Center at Texas BioMed.

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Lifespan.io

 A new study published in mSystems, a journal from the American Society for Microbiology, shows that the skin and mouth microbiomes are better predictors of age than the gut microbiome.

A very broad study

The authors used a very large population that is highly impressive among studies of this kind. Previously, a team containing some of the same researchers had done a gut microbiome study of over four thousand people from multiple countries [1]. This time, the researchers took skin, saliva, and fecal samples from roughly 2,000, 2,500, and 4,500 people, respectively; this study was done with nearly 9,000 people in total, and the team stated that it was the most comprehensive microbiome study done to date. The team used a “random forest” machine learning approach to determine what microbiota were and were not predictive of age [2].

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Wall Street’s Biotech Investment Wizard — On this most recent ideaXme (http://radioideaxme.com/) episode, I was honored to be joined by my friend, and biotech / pharma / healthcare investment banker extraordinaire, Frederick Frank, to talk about his 50-year career history behind the industry’s mega-deals — #Ideaxme #Biopharma #Biotech #WallStreet #Mergers #Acquisitions #VentureCapital #Genentech #Roche #BristolMyersSquibb #PrivateEquity #Health #Wellness #Longevity #Regeneration #LifeExtension #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Fred Frank, Founder and Chair of Evolution Life Science Partners, an investment bank focused on the needs of life sciences and healthcare companies.

Ira Pastor Comments:

On several recent shows we’ve been discussing some of the novel, alternative funding pools that have been emerging in and around the biotech space, specifically related to some of the unmet medical needs of which we have been focusing on, on the ideaXme show, particularly related to the age-tech and longevity biotech fronts.

We have had guests join us from both the $125 Million Healthy Ageing Challenge program of UKRI (UK Research and Innovation)and the US$30 Million Healthy Longevity Global Grand Challenge of the U.S. National Academy of Medicine. We’ve have also talked to folks at the XPrize Foundation, specifically related to their upcoming inducement prize contest for therapeutics for the diseases of aging.

Continue reading “Biotech’s Wizard Of Wall Street : Fred Frank At The Forefront of Investment” | >

A molecular switch has been identified by scientists at the University of California that controls the immune machinery which is responsible for chronic inflammation within the body; findings published in the journal Cell Metabolism may lead to new ways to halt and/or reverse age related conditions such as cancer, diabetes, Alzheimer’s and Parkinson’s disease.

“My lab is very interested in understanding the reversibility of aging,” said senior author Danica Chen, associate professor of metabolic biology, nutritional sciences and toxicology at UC Berkeley. “In the past, we showed that aged stem cells can be rejuvenated. Now, we are asking: to what extent can aging be reversed? And we are doing that by looking at physiological conditions, like inflammation and insulin resistance, that have been associated with aging-related degeneration and diseases.”

A bulky collection of NLRP3 inflammasome immune proteins which are responsible for sensing potential threats to the body and launching an inflammatory response were shown to be essentially switched off by removing some molecular matter in a deacetylation process. Overactivation of NLRP3 inflammasomes is linked to a range of chronic conditions such as cancer, dementia, diabetes, and multiple sclerosis; this study suggests that drugs targeted towards deacetylation these NLRP3 inflammasomes may help to prevent and/or treat many age related conditions and even possibly age related degeneration itself in general.

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