Like.
Category: life extension – Page 385
Bioengineered hybrid muscle fiber for regenerative medicine
Muscle constitutes the largest organ in humans, accounting for 40% of body mass, and it plays an essential role in maintaining life. Muscle tissue is notable for its unique ability for spontaneous regeneration. However, in serious injuries such as those sustained in car accidents or tumor resection which results in a volumetric muscle loss (VML), the muscle’s ability to recover is greatly diminished. Currently, VML treatments comprise surgical interventions with autologous muscle flaps or grafts accompanied by physical therapy. However, surgical procedures often lead to reduced muscular function, and in some cases result in a complete graft failure. Thus, there is a demand for additional therapeutic options to improve muscle loss recovery.
A promising strategy to improve the functional capacity of the damaged muscle is to induce de novo regeneration of skeletal muscle via the integration of transplanted cells. Diverse types of cells, including satellite cells (muscle stem cells), myoblasts, and mesenchymal stem cells, have been used to treat muscle loss. However, invasive muscle biopsies, poor cell availability, and limited long-term maintenance impede clinical translation, where millions to billions of mature cells may be needed to provide therapeutic benefits.
The NIA Is Funding Clinical Trials Against Aging
Companies that are creating rejuvenation biotechnology interventions must develop their products to target individual diseases in order to be approved by the FDA. While that is still the case, this particular FOA is intended to promote broader research that does not necessarily target individual diseases as endpoints.
The National Institutes of Aging in the United States, a component of the National Institutes of Health, is funding clinical trials for interventions that directly affect the root causes of age-related diseases.
Direct funding for trials against aging
Probably the most important and interesting part of this Funding Opportunity Announcement (FOA) is that the NIA specifically mentions “multiple chronic conditions” caused by the processes of aging along with more conventional trials that are targeted directly at specific downstream effects of aging.
Reverse Age
This is the FIRST part of the interview with Rodolfo Goya.
In this video Professor Goya talks about his role in the original experiment and the progress in his current study to reproduce the results with young blood plasma.
Professor Rodolfo Goya is Senior Scientist at The National Scientific and Technical Research Council in Argentina where he is a biochemist and researcher.
Dr. Goya has led a number of studies on cellular reprogramming and restoration of function in important organs, such as the thymus and the brain. He is also studying different aspects of cryopreservation.
He was one of the authors of the paper “Reversing age: dual species measurement of epigenetic age with a single clock” and is now working in his lab to reproduce and extend the results.
Gut microbiome implicated in healthy aging and longevity
The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism.
David Sinclair and Bracken Darrell take the stage on aging and life extension (Feb 2021)
Excellent hand and hand conversation between David Sinclair and Bracken Darrell. David is an expert in longevity and life extension, and Bracken is an experienced successful businessman, CEO of multinational Logitech.
The encounter took place on February 92021, during an online scientific symposium organized by the American Federation of Aging Research (AFAR).
The Symposium was launched under the following theme: “The Future is Now: Innovations in AI and Big Data for Healthspan and Longevity and it was a tribute to global geroscience visionary Sami Sagol.
If you’re familiar with the longevity field very likely you know who David Sinclair is, but for those who haven’t heard of Bracken Darrell before, he is an experienced and successful businessman, CEO of the Multinational Logitech.
Well known longevity leader Nir Barzilai acted as presenter and moderator of the conversation.