An amyloid protein targeted by Alzheimer’s disease therapies seems to be involved in normal mental decline.
Category: life extension – Page 4
Ray Kurzweil, who used to be a computer scientist at Google, is no stranger to accurate predictions. With an impressive track record, he foresaw consumers designing their own clothes from home computers by 1999 and the world’s best chess player losing to a computer by 2000. He had also predicted the widespread use of portable computers in various shapes and sizes by 2009.
His groundbreaking forecasts have consistently inspired people to push the boundaries of what is possible. Ray Kurzweil has so far made 147 predictions with 86% accuracy and has the world looking forward to the new ones with much anticipation. For his remarkable contributions and insight, the visionary was awarded the prestigious National Medal of Technology in 1999. He was also inducted into the National Inventors Hall of Fame in 2022.
The renowned futurist predicts that AI will surpass human intelligence and pass the Turing test by 2029. And that by 2045, humans will merge with the artificial intelligence we’ve created, a phenomenon he calls ‘The Singularity.’ He believes this would exponentially amplify our intelligence, creating unparalleled opportunities for innovation and progress.
The fields of regenerative medicine and cellular biology are advancing rapidly, demonstrating that some aging-related processes may be more reversible than previously thought.
Recent research has shown that it is possible to rejuvenate the skin cells of a 53-year-old woman by 30 years, a groundbreaking scientific achievement that could redefine modern approaches to treating age-related diseases.
Cellular aging is a complex process marked by gradual changes in cell structure and function. Over time, alterations in gene expression, DNA damage accumulation, and reduced tissue regeneration capacity occur.
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“This indicates that ergothioneine influences the metabolism in a similar way to performance-enhancing agents,” Filipović said. He plans to carry out a study involving healthy human volunteers to evaluate whether the compound can similarly enhance performance in people.
By offering a clearer perspective on how ergothioneine improves muscle health, stress resilience, and cellular defenses, this research sets the stage for new strategies aimed at maintaining good health into advanced age.
As further investigations confirm these findings in humans, the mushroom compound ergothioneine may emerge as a valuable resource for countering age-related diseases and promoting a more robust, active life.
“Our woolly mouse project drove innovations in areas combining the end to end process from our computational biology analysis tools to our multiplex precision genome engineering technologies,” Lamm told us. “These technologies enable precise and efficient genetic modifications at multiple sites within the genome at the same time, which could help with research focused on addressing the complex multi-genetic age-related diseases in the future.”
By further refining the genetic engineering techniques developed by Colossal, researchers may eventually develop therapies tailored to an individual’s genetic makeup, mitigating the effects of aging at a cellular level.
“Many diseases are multigenic in nature and require deep analysis computationally and being able to edit the genome at multiple sites with high degrees of efficiency to not cause off-target effects,” Lamm told us. “Our end to end process and the further development of our multiplex editing and DNA synthesis capabilities will lead to others being able to use our tools and system to treat these more complicated diseases. Together, these innovations are part of the science focused on developing personalized, targeted therapies to mitigate the effects of aging, accelerate the development of regenerative medicine, and extend both lifespan and healthspan.”
Microsoft Dragon Copilot provides the healthcare industry’s first unified voice AI assistant that enables clinicians to streamline clinical documentation, surface information and automate tasks
Posted in biotech/medical, finance, life extension, robotics/AI | Leave a Comment on Microsoft Dragon Copilot provides the healthcare industry’s first unified voice AI assistant that enables clinicians to streamline clinical documentation, surface information and automate tasks
REDMOND, Wash. — March 3, 2025 — On Monday, Microsoft Corp. is unveiling Microsoft Dragon Copilot, the first AI assistant for clinical workflow that brings together the trusted natural language voice dictation capabilities of DMO with the ambient listening capabilities of DAX, fine-tuned generative AI and healthcare-adapted safeguards. Part of Microsoft Cloud for Healthcare, Dragon Copilot is built on a secure modern architecture that enables organizations to deliver enhanced experiences and outcomes across care settings for providers and patients alike.
Clinician burnout in the U.S. dropped from 53% in 2023 to 48% in 2024, in part due to technology advancements. However, with an aging population, and persistent burnout felt across the profession, a significant U.S. workforce shortage is projected. In response, health systems are adopting AI to streamline administrative tasks, enhance care access, and enable faster clinical insights to improve healthcare globally.
“At Microsoft, we have long believed that AI has the incredible potential to free clinicians from much of the administrative burden in healthcare and enable them to refocus on taking care of patients,” said Joe Petro, corporate vice president of Microsoft Health and Life Sciences Solutions and Platforms. “With the launch of our new Dragon Copilot, we are introducing the first unified voice AI experience to the market, drawing on our trusted, decades-long expertise that has consistently enhanced provider wellness and improved clinical and financial outcomes for provider organizations and the patients they serve.”
In this video, we explore seven astonishing breakthroughs leading us closer to age reversal and longer, healthier lives by 2025. From mapping the complete fruit fly brain for deeper insights into neurobiology, to AI-driven drug discovery breakthroughs by Insilico Medicine, these cutting-edge innovations are changing the way we understand and tackle aging. We’ll also dive into the growing world of microbiome-targeting startups, and Dr. Ben Goertzel’s vision for an AI-driven future where extended longevity and superintelligence converge. Whether you’re interested in the most advanced biotech research, the latest in computational biology, or the promise of AGI to transform healthcare, this video covers the game-changing science that could redefine what it means to grow older.
Stay tuned for expert insights on how these remarkable advancements might help us inch closer to “longevity escape velocity.” Be sure to check the description for links to the studies, articles, and visionary leaders shaping tomorrow’s health landscape.
00:00 intro.
01:25 Dont Die Documentary Cameo.
03:30 Folistatin Gene Therapy.
06:15 Cellular Reprogramming.
09:00 Decentralized Science.
11:50 Human Brain Simulation.
14:53 AI Designed Drugs.
18:08 Microbiome.
21:25 Ben Goertzel AI+Longevity.
Mentioned vids: part 1: the surprising environmental impacts of an aging cure. • the surprising environmental impacts…
Ben Goertzel Interview:
• AGI, SingularityNET, Longevity Escape…
SOURCES:
Aging depletes the brain’s protective sugar shield, weakening defenses and fueling cognitive decline, but restoring key sugars may reverse these effects.
What if a critical piece of the puzzle of brain aging has been hiding in plain sight? While neuroscience has traditionally focused on proteins and DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Researchers discovered AP2A1, a protein controlling cellular aging. Lower AP2A1 reversed aging effects, while higher levels sped aging.