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Archive for the ‘life extension’ category: Page 4

Apr 29, 2022

YouthBio CEO: The time is right to develop epigenetic reprogramming therapies

Posted by in categories: biotech/medical, genetics, life extension

Earlier this month, we brought you the news that epigenetic reprogramming startup YouthBio Therapeutics had emerged from stealth. The company shed some light on its plans to develop epigenetic reprogramming therapies for age-related diseases by rejuvenating certain cells in our bodies. YouthBio aims to achieve this rejuvenation by developing gene therapies that enable partial cellular reprogramming – an area of longevity science that is now attracting significant commercial interest.

Longevity. Technology: Cellular reprogramming refers to the process of returning adult cells to a “pluripotent” state: blank, embryonic-like cells that can become any cell in the body. This reprogramming can be achieved using techniques based on the discovery of Yamanaka factors.

Apr 28, 2022

Researchers Rejuvenate Mouse Organs Through Cellular Reprogramming

Posted by in categories: biotech/medical, life extension

Scientists led by Dr. Manuel Serrano have observed symptoms of rejuvenation in the pancreas, liver, spleen, and blood of mice after applying one cycle of cell reprogramming.

To achieve this, the researchers have characterized rejuvenation by studying molecular marks in the DNA, gene expression, and cell metabolism. The study has been published in the journal Aging Cell.

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Apr 27, 2022

Why study the biology of aging? See how hundreds of scientists at AbbVie and Calico Life Sciences are advancing research in age-related diseases like neurodegeneration and cancer

Posted by in categories: biotech/medical, life extension

With an aging global population, time is of the essence to find novel targets and therapies for age-related diseases.

Apr 27, 2022

Japan university tackles aging with transplanted pluripotent stem cells

Posted by in categories: biotech/medical, life extension

A research team from Osaka University in Japan has concluded that a clinical trial of transplanted IPS cell-derived corneal tissue was safe and effective – further evidence that cellular reprogramming with Yamanaka factors is moving towards scalable therapies.

Longevity. Technology: The clinical trial spanned several years and used corneal tissues derived from induced pluripotent stem cells. The tissue was transplanted into four almost-blind patients, and, according to the research team, none of the patients experienced rejection or tumorigenicity of the transplanted cells and all saw improvements in their symptoms, with three experiencing improved eyesight, with one improving from 0.15 to 0.7. Importantly, all were free of side effects one year later.

IPS cells can be generated from any adult cell, with Yamanaka factors – a group of protein transcription factors from four master genes. These induced stem cells demonstrate the significant quality of pluripotency – they can differentiate into all other cell types of the body. This is incredibly useful both for research and for therapy.

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Apr 25, 2022

Cryonics Institute’s Annual General Meeting 2022

Posted by in categories: cryonics, life extension

Sun, Sep 11 at 12 PM CDT.


This is an invitation to the Annual General Meeting of the Cryonics Institute & the Immortalist Society.

The Cryonics Institute’s Annual General Meeting (AGM) will be held on Sunday, September 11th 2022 from 3:00pm to 6:30pm at the Infinity Hall & Sidebar 16,650 E. 14 Mile Rd, Fraser, MI 48,026 (USA). For more information visit www.infinityhallsidebar.com

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Apr 24, 2022

Researchers have discovered a de-ageing technique that made skin cells 30 years younger

Posted by in categories: biotech/medical, genetics, life extension

This is not the first successful research on de-ageing cells. Earlier, Shinya Yamanaka, a Nobel prize-winning stem cell researcher, genetically reprogrammed the mouse skin cells and turned them into induced pluripotent stem cells, or iPSCs, back in 2006. These cells type had the potential to form any cell type in the body. Yamanaka’s method took 50 days and completely reprograms cells to the biological age of an embryo. Gill’s method only took 13 days.

In a statement, Gill said, “Our results represent a big step forward in our understanding of cell reprogramming. We have proved that cells can be rejuvenated without losing their function and that rejuvenation looks to restore some function to old cells.”

Apr 23, 2022

Morgan Levine is interviewed by Rhonda Patrick on Longevity. My picks on it

Posted by in categories: biotech/medical, chemistry, life extension

This is a 10-minute version with my picks on an hour-and-a-half interview on the longevity science made by Rhonda Patrick to Morgan Levine.

The link to the entire interview, which took place on April 12, 2022, is in the description of the video.

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Apr 23, 2022

Sonia Arrison — Author, Analyst, Investor, Entrepreneur — Positively Impacting Human Longevity

Posted by in categories: biotech/medical, economics, life extension, singularity

Making positive impacts on human longevity — sonia arrison, author, analyst, investor, entrepreneur.


Sonia Arrison (https://soniaarrison.com/) is a best-selling author, analyst, entrepreneur, and investor.

Continue reading “Sonia Arrison — Author, Analyst, Investor, Entrepreneur — Positively Impacting Human Longevity” »

Apr 23, 2022

Future Of Aging & Cellular Reprogramming | Eleanor Sheekey Ep 4

Posted by in categories: biotech/medical, chemistry, life extension, media & arts

She gives a great analogy of slowing aging versus reversing aging, and I did not realize Yamanaka Factors were not so perfect in current use.


In this video Eleanor talks about the her view on Longevity Escape Velocity and reprogramming with Yamanaka factors and some of the issues around this technology.

Continue reading “Future Of Aging & Cellular Reprogramming | Eleanor Sheekey Ep 4” »

Apr 22, 2022

Different responses to DNA damage determine ageing differences between organs

Posted by in categories: biotech/medical, life extension

Organs age differently. To investigate the basis of organ-specific ageing we systematically compared at the tissue, stem cell and organoid level two organs representing ageing extremes, from accelera…

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