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Category: life extension – Page 413
Molecular ‘switch’ reverses chronic inflammation and aging
Chronic inflammation, which results when old age, stress or environmental toxins keep the body’s immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer’s and Parkinson’s to diabetes and cancer.
Now, scientists at the University of California, Berkeley, have identified a molecular “switch” that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.
“My lab is very interested in understanding the reversibility of aging,” said senior author Danica Chen, associate professor of metabolic biology, nutritional sciences and toxicology at UC Berkeley. “In the past, we showed that aged stem cells can be rejuvenated. Now, we are asking: to what extent can aging be reversed? And we are doing that by looking at physiological conditions, like inflammation and insulin resistance, that have been associated with aging-related degeneration and diseases.”
Revitalizing the Aging Brain by Activating Immune Cells
Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which will be published on February 5, 2020, in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline and combat aging-associated neurodegenerative disease in humans.
The brain is highly susceptible to aging, with cognitive functions, such as learning and memory, gradually declining as we get older. Much of the body’s immune system also deteriorates with age, resulting in increased susceptibility to infection and higher levels of inflammation. In their new JEM study, however, a team of researchers led by Qi Yang and Kristen L. Zuloaga at Albany Medical College reveal that aging-related changes in a class of immune cell known as group 2 innate lymphoid cells (ILC2s) could allow doctors to combat the effects of aging on the brain.
ILC2s reside in specific tissues of the body and help to repair them when they are damaged. Recently, for example, ILC2s in the spinal cord were shown to promote healing after spinal cord injury. “However, whether ILC2s also reside in other parts of the central nervous system, and how they respond to aging, was unknown,” Yang says.
Cyberpunk 2077 — Official 4K Gameplay Deep Dive
Watch the worldwide reveal of brand new game footage from Cyberpunk 2077!
This video contains work-in-progress gameplay — everything you see is potentially subject to change.
Cyberpunk 2077, the open-world, action-adventure story from CD PROJEKT RED, is coming to Xbox One, PS4 and PC April 16th, 2020.
Pre-order now: https://www.cyberpunk.net/pre-order
About Cyberpunk 2077:
In the most dangerous megacity of the future, the real you is not enough. Become V, a cyber-enhanced mercenary outlaw going after a one-of-a-kind implant — the key to immortality. Customize your cyberware and skillset, and explore a vast city of the future obsessed with power, glamour and body modification. The choices you make will determine the story and shape the world around you.
Refining the Allotopic Expression of Mitochondrial Genes
Researchers from SENS Research Foundation, including Matthew O’Connor and Amutha Boominathan, have published a new study showing how codons play an important role in getting copies of mitochondrial genes placed in the cellular nucleus to express themselves correctly [1].
A possible solution to mitochondrial diseases
Mitochondrial disease is not a single disease; in fact, it is a group of rare and related conditions that are thought to affect perhaps 1 in 5000 people. These are caused due to mutations in the genes involved in the process of aerobic respiration, one of the main functions of our mitochondria.
Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
Both genetically altered and naturally long-lived mammals are more resistant to toxic compounds that may cause cancer and age-associated diseases than their shorter-lived counterparts. The mechanisms by which this stress resistance occurs remain elusive. We found that longer-lived rodent species had markedly higher levels of signaling activity of the multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) and that this increase in cytoprotective signaling appeared to be due to species differences in Kelch-like ECH-Associated Protein 1 (Keap1) and β-transducin repeat-containing protein (βTrCP) regulation of Nrf2 activity. Both of these negative regulators of Nrf2-signaling activity are significantly lower in longer-lived species. By targeting the proteins that regulate Nrf2 rather than Nrf2 itself, we may be able to identify new therapies that impact aging and age-associated diseases such as cancer.
The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and neurodegeneration. The mechanisms behind the universal resilience of longer-lived organisms to stress, however, remain elusive. We hypothesize that this resilience is linked to the activity of a highly conserved transcription factor, nuclear factor erythroid 2-related factor (Nrf2). Nrf2 regulates the transcription of several hundred cytoprotective molecules, including antioxidants, detoxicants, and molecular chaperones (heat shock proteins). Nrf2 itself is tightly regulated by mechanisms that either promote its activity or increase its degradation.
Dr. Michael Fossel, President of Telocyte
He remarks that we are at Kittyhawk as far as life extension goes. Most folks, including the Wright brothers, did not see a widespread use for aircraft at the time. Today in life extension the scientists working on it really do know what they are chasing.
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Radical Life Extension in the Posthuman Era — Dr. Aubrey de Grey interviewed by Prof. Ferrando (NYU)
Vlog “Posthumans” — Episode 22
Dr. Francesca Ferrando (NYU) interviews Dr. Aubrey de Grey, (SENS Research Foundation). Recorded at Princeton University (US), November 2019. Video-grapher and video-producer: Julian Boilen.
More info: http://www.theposthuman.org/vlog-posthumans.html
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DR STEPHEN BADYLAK — Regen Med Strategies for Tissue & Organ Replacement (Long Version)
Regenerative medicine and furthermore tissue engineering are realities for some time but well hidden from the public by msm somehow.
Dr. Stephen Badylak, Director of the Center for Pre-Clinical Tissue Engineering, McGowan Institute for Regenerative Medicine.
Badylak Lab: Research and Publications: http://www.mirm.pitt.edu/badylak/