A lil bit of everything from overpopulation to growing interest. Aubrey says a 50% chance in 15 to 20 years but he is planning human trials starting in 2021.
Aubrey de Grey — #Longevity18
Posted in life extension
Category: life extension – Page 437
If you are a PR wizard, deep into the rejuvenation market, help us speed up the transition to a world without age-related diseases.
New research has identified a type of bacteria found in the microbiomes of elite athletes that contributes to improved capacity for exercise. These bacteria, members of the genus Veillonella, are not found in the guts of sedentary people.
By taking a closer look at the bacteria, the researchers from Joslin Diabetes Center determined Veillonella metabolizes lactic acid produced by exercise and converts it into propionate, a short chain fatty acid. The human body then utilizes that propionate to improve exercise capacity. The results were reported today in Nature Medicine.
“Having increased exercise capacity is a strong predictor of overall health and protection against cardiovascular disease, diabetes, and overall longevity,” says Aleksandar D. Kostic Ph.D., TITLE., a co-author on the paper. “What we envision is a probiotic supplement that people can take that will increase their ability to do meaningful exercise and therefore protect them against chronic diseases including diabetes.”
Die. Freeze Body. Store. Revive
Posted in cryonics, finance, life extension
Cryonicists are banking on the idea that future technology will allow preserved bodies to be brought back to life.
Researchers from Washington University School of Medicine in St. Louis have discovered a way to delay aging in mice with a protein that is abundant in the blood of young mice but declines with age.
eNAMPT and the NAD salvage pathway
That protein is extracellular nicotinamide phosphoribosyltransferase (eNAMPT), and it plays a key role in the process that cells use to create nicotinamide adenine dinucleotide (NAD), a crucial component that they need for energy production. NAD is a coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide.
A very good article on the life and ideas of life extensionists/immortalists/longevity’s: “… Strole is now 70. He lives in Scottsdale, Arizona, a desert town. In the life-extensionist mode, he avoids dairy and rarely touches bread, though he devours a whole heap of other things. Recently his diet has included pills, branded ”Cognitive”, which he takes twice a day and claims have all sorts of nourishing effects on his brain. (What good is maintaining the body if not the mind?) The pills are part of a self-directed anti-ageing process that requires a lot of swallowing. On some days, Strole takes 70 supplements, including a tablet that ”energises the mitochondria” (mitochondria produce energy) and whose effects resemble ”a shot of coffee, minus the jitters”, as well as vitamins, multi-nutrients and metformin, a diabetes drug that has become so popular among life extensionists that one referred to it as ”the aspirin of anti-ageing”. In the early mornings, when the Arizona air is still brisk, he takes a cold dip in his pool to shock his immune system into better function, and at some point or another he lies face-up on an electromagnetic mat that whirs silently against his body and ”opens up the veins”, and engages in a breathing regime that, he says, ”balances the hormones”.
Some sleep on electromagnetic mats, others pop up to 150 pills a day. But are ‘life extensionists’ any closer to finding the key to longevity? Alex Moshakis meets some of the people determined to become immortal.
Wondering if people can be brought back from cryonics freezing and still function as normal? Chick this out.
Justin Smith, 26, was brought back to life after being found with no pulse in the snow.
A research team led by the University of Cologne has identified the transcription factor Ets21c as a vital regulator of the regenerative system within the adult intestine of the fruit fly Drosophila. The study highlights the existence of trade-off mechanisms between stress resilience and longevity.
The intestinal epithelium is involved in nutrient absorption and digestion, but also serves as a selective barrier that prevents the intrusion of pathogens and toxic substances. The intestine is renewed over an organism’s lifetime through the function of stem cells that are capable of differentiating to maintain the tissue integrity and function.
On the other hand, stem cell malfunctions have been linked to tissue degeneration or cancer development. The research is shedding new light on the molecular basis of the regenerative processes under both favorable and stressful conditions.
21st Century Medicine has developed an entire platform technology focused on the creation and commercialization of hypothermic preservation and cryopreservation techniques that enable protection, preservation, transportation, storage & future use of valuable living systems. These developments have taken science far beyond conventional preservation limits. 21CM scientists continue to prove long-term protection and preservation of complex living systems is not only possible, but commercially viable.
It means that a vital link has been created that we call “Bio Logistics”.
Biopharmaceutical companies get a larger window in which to test new drug candidates on viable premade and cryopreserved tissue slices that function like fresh.