Lifeboat Foundation

Hypertension is an increasingly encountered condition in modern society, as sedentary lifestyles, poor diet, and other unhealthy lifestyle choices are becoming more prevalent.

The aging processes generally cause our blood pressure to rise, as they steadily clog our arteries, stiffen blood vessels, and cause our hearts to work harder to get blood to all our tissues. However, the rate at which this happens is subject to a great deal of variation, and diet and lifestyle are two big influences on this. At least initially, hypertension is frequently self-inflicted and something that we can reverse to a certain extent, as a new study shows.

Researchers have recently demonstrated that a program seeking to help people change their lifestyles through diet and exercise was almost as effective as some medications for reducing blood pressure.

The idea of “healthy ageing” is a contradiction in terms.

Suppose you read the following sentence in an article about company management: “This factor is central in achieving successful bankruptcy.” It sounds rather weird, doesn’t it? What if you read this about football team training? “Contrary to popular belief, it is possible to lose a game in a successful way.” These are so-called oxymorons—by Oxford’s definition, “figures of speech in which apparently contradictory terms appear in conjunction.”

The contradictory nature of the statements above is more than just apparent—bankruptcy is the exact opposite of “success” for a company, and the same goes for losing a game for a football team. One can get very creative with these: “a blockbuster fiasco”; “the façade of the building deteriorated nicely”; and so on. Examples closer to home would be “healthy aging” or “aging gracefully”.

Continue reading “Getting sick in a healthy way” »

Really excited to announce our new initiative to make early-stage rejuvenation therapies more accessible.

Our mission is to enable people to vastly extend their healthy lifespan and be part of the first generation to cure aging.

We support the development of rejuvenation therapies that undo the damage of aging by funding basic research, bringing together the world’s leading scientists at our annual Undoing Aging conference and helping startups that work on actual therapies for human use.

Continue reading “Review current and up-coming rejuvenation therapies” »

We were interested to learn that Juvenescence Limited, a biotech and development company involved in the development of therapies that target the aging processes, has successfully raised $50 million in a series A financing round.

Jim Mellon, the chairman of Juvenescence Limited, said, “We are delighted with the progress we have made and the faith that investors have placed in us to build a world-class company, one that we hope will lead the field in longevity science for the benefit of humanity as well as yield superb returns for our shareholders. Our company ethos is to advance the science that will add years of healthy life to every human being, and that is exactly what we are executing on at record speed.”

Juvenescence has raised $63 million from various international investors since its creation in October 2016 and is now moving forward with a number of key projects. The company is comprised of a number of industry leaders in business as well as a solid scientific team led by Dr. Declan Doogan and Dr. Annalisa Jenkins.

Continue reading “Juvenescence Completes $50 Million Series A Financing Round” »

Today we are going to take a look at the emerging theory that inflammaging, a chronic, age-related background of inflammation, is caused by alterations to the populations of intestinal microbes.

What is inflammaging?

Inflammaging is a term coined to describe the chronic, smoldering background of inflammation that accompanies the aging process. It is constant, low-grade inflammation that interferes with stem cell mobility, cellular communication, and the immune system’s ability to operate correctly.

While we’re not off the hook for paying taxes, Dr. Aubrey de Grey believes that we may be able to avoid (or at least prolong) our until-now inevitable mortality.

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Continue reading “Living Forever The Secret to Not Aging” »

One of the most commonly asked questions we receive is “How is progress going in aging research?” It is something we are asked so often that we decided to provide the community with a resource that will help them to keep track of progress directly.

To that end, today we have launched our new curated database, The Rejuvenation Roadmap, which will be tracking the progress of the many therapies and projects in the rejuvenation biotechnology field. This database aims to give a quick visual summary of the status of each drug or therapy along with some additional information for people interested in learning more about them.

We believe that an informed community is an effective one, and this was one of our motivations for developing this new database. There are many resources for scientists, such as the superb databases of the Human Ageing Genomic Resources maintained by Dr. João Pedro de Magalhães, which are excellent for researchers. However, we noticed that there was no database that tracked the efforts of the many researchers and projects in the field, and while some people do maintain lists, they are often not public facing, easy to access, or user-friendly.