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Regenerative Medicine: Fat-derived Stem Cells — Medical Frontiers-JAPAN Live & Programs

This 2-part series on “Regenerative Medicine” shows how it is possible to replace lost or damaged body parts by using human cells. Surviving a disease such as cancer can leave scars, both physical and emotional. Whether it’s due to a mastectomy or radiation therapy, scars are hard to avoid. Fat-derived stem cells can help patients return close to their original state, providing peace of mind. We also look at the benefits of using oil to balance the amount of fat in a body.

Mesenchymal stem cells: a new trend for cell therapy

Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical applications, and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic.

Keywords: mesenchymal stem cell, cell therapy, tissue injury, degenerative disease, immune disorder, graft-versus-host disease, immunomodulation, trophic factor.

Stem cells are unspecialized cells with the ability to renew themselves for long periods without significant changes in their general properties. They can differentiate into various specialized cell types under certain physiological or experimental conditions. Cell therapy is a sub-type of regenerative medicine. Cell therapy based on stem cells describes the process of introducing stem cells into tissue to treat a disease with or without the addition of gene therapy. Hematopoietic stem cells (HSCs) have been widely used for allogeneic cell therapy. The successful isolation of pluripotent embryonic stem (ES) cells from the inner cell mass of early embryos has provided a powerful tool for biological research. ES cells can give rise to almost all cell lineages and are the most promising cells for regenerative medicine.

Aging Well – Aubrey de Grey, PhD, Co-founder of SENS Research Foundation – Taking the Fight to An… — YouTube

In this podcast, Aubrey de Grey, Ph.D., and the Chief Science Officer/Co-founder of SENS Research Foundation discusses his fascination with aging and his ongoing efforts to change the way we think about, and treat, age-related conditions. Dr. de Grey is a biomedical gerontologist and the innovative developer of the SENS platform. He is a Fellow of the Gerontological Society of America and the American Aging Association. He received a Ph.D. in Biology from the prestigious University of Cambridge. Dr. de Grey states that aging is the greatest medical problem we face as it causes the most suffering. He discusses the various excuses that are given as reason to simply disregard aging as a field in need of greater research, from the standard, ‘everything ages, just accept it,’ to the more philosophical—‘death, by its existence, gives meaning to life,’ and the social excuse—‘treating aging in a new way would only create new problems that could be much worse.’ But according to Dr. de Gray, not a single excuse holds up, all fall to the slightest scrutiny when really considered. Dr. de Grey explains that in order to design and implement therapies that will prevent the health problems of an aging population, we need to learn from what has already been proven and acknowledged in the past. SENS Research Foundation seeks to develop and promote access to innovative new therapies that can cure or possibly even prevent the diseases and difficult, troubling disabilities of aging by repairing built-up damage in our bodies. Wrapping up, Dr. de Grey explains cell therapy and damage, loss of cells, and the processes needed to bring about the repair. And the doctor goes into detail regarding the injection of stem cells to repair the damage, replace lost cells, etc.

Compound with anti-aging effects passes human trial

Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, could help slow certain aging processes. EPFL spin-off Amazentis, in conjunction with EPFL and the Swiss Institute of Bioinformatics, has published a paper Metabolism outlining the results of their clinical trial.

It is a fact of life that skeletal muscles begin to lose strength and mass once a person reaches the age of 50. A recent clinical trial involving two EPFL entities — spin-off Amazentis and the Laboratory of Integrative Systems Physiology (LISP) — showed that urolithin A, a compound derived from biomolecules found in fruits such as pomegranates, could slow down this process by improving the functioning of mitochondria — the cells’ powerhouses. A joint paper presenting the results of the trial also demonstrates that ingesting the compound poses no risk to human health.

Slowing mitochondrial aging.

Regenerage International, IIMET, and Bioquark Inc. to Collaborate on Clinical Study in Biologic Age Reversal of Photodamaged Skin

https://www.prweb.com/releases/regenerage_international_iime…449142.htm

Pretty girl applying moisturizing cream in front of mirror

Astrocyte Senescence Leads to Neurotoxicity

In a recent study, a group of researchers from Hebrew University-Hadassah Medical School, Feinberg School of Medicine, and Tel Aviv University examined astrocytes in mice and found that these cells exhibited a senescent phenotype that led to neurodegeneration and neurotoxicity [1].

Age-dependent increase in senescent astrocytes adjacent to Aβ plaques

Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent… These cells are caused primarily by telomere shortening and DNA damage, they are known to contribute to many diseases, and this is not the first study that links them to neurodegeneration.

Man with brain implant on Musk’s Neuralink: “I would play video games”

The three-hour event was part marketing spectacle and part dry technical explainer. Musk and his team members described the brain-machine interface design they’re betting on, which will employ dozens of thin wires to collect signals in the brain, and which they want to try out on paralyzed people soon, so they can type with their minds. Their eventual aim is to connect those wires to a thought transmitter which tucks behind your ear like a hearing aid.


Well, it’s pretty cool. It seemed like maybe it will work the way they want down the road, but it probably doesn’t work that way now. A couple of years ago, when I heard he was working with a neural interface, I said I would be there in a heartbeat. I was joking, but it’s interesting to think about what I am going to do when I get explanted. I am coming up on my five years. Then the FDA says my implants may have to come out. Neuralink talked about longevity of the implant and also a large number of electrodes. I always say I wish they had put more electrodes into me.

Basically, the more electrodes you have, the more neurons you record from, so I would imagine higher-degree tasks would be easier. I am limited to thinking about my right arm and hand. I thought it would be good to have more control. I always want to play more video games.

I was going to school at Penn State, Fayette, for nanofabrication, so I didn’t have a job, I was in school.

Brent Nally interviews Dr. Aubrey de Grey @ SENS on July 17, 2019

My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself. I read the books and do all the research and share my findings with you!

This video is an interview of Dr. Aubrey de Grey @ SENS on July 17, 2019. My wife, Lauren Nally, was our camerawoman.

- Please consider a donation so I can continue to keep my YouTube ads off: My Bitcoin Cash (BCH) address: qr9gcfv92pzwfwa5hj9sqk3ptcnr5jss2g78n7w6f2 or https://www.paypal.me/BrentNally
- Please consider a donation to SENS: https://www.sens.org/

SHOW NOTES:

- Aubrey’s wikipedia: https://en.wikipedia.org/wiki/Aubrey_de_Grey
- SENS wikipedia: https://en.wikipedia.org/wiki/SENS_Research_Foundation
- like & follow SENS on Facebook: https://www.facebook.com/sensf/?ref=br_rs
- subscribe to Undoing Aging’s YouTube channel: https://www.youtube.com/channel/UCAwxbQhlE6qcTXmKcxkaCGA/videos
- follow Aubrey on Twitter: https://twitter.com/aubreydegrey
- follow SENS on Twitter: https://twitter.com/senstweet
- follow Aubrey on LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b/
- follow SENS on Instagram: https://www.instagram.com/sensresearchfoundation/
0:55 Type “Aubrey de Grey” into YouTube for lots of his lectures & interviews.
1:50 Update on the state of the anti-aging industry & explosion of private sector interest.
5:05 Intro for Aubrey
5:35 My May 30, 2019 interview with Sierra Sciences CEO Dr. Bill Andrews: https://www.youtube.com/watch?v=Tx9yG6iTROQ
6:25 diversity of messaging in anti-aging is increasing.
7:10 My July 10, 2019 interview with BioViva CEO Liz Parrish: https://www.youtube.com/watch?v=oBFTwGPaPr4
8:28 Aubrey shares his updated thoughts on the role of telomerase in cancer in humans.
12:00 Liz had here telomeres tested by SpectraCell Laboratories: https://www.spectracell.com/clinicians/products/telomere-testing/ & LifeLength: https://lifelength.com/
14:10 there has recently been more testing on humans in the field of the biology of aging.
15:44 It’s obvious to Aubrey & I that aging is a big problem but most people still don’t understand this.
18:40 profound difference between how scientists & technologists think.
22:11 Watch the documentary “The Immortalists” about Dr. Aubrey de Grey & Dr. Bill Andrews: https://www.theimmortalists.com/watch/?
22:58 updates on anti-aging investments & research projects.
30:01 stem cell therapy is intended to repair cell loss.
30:50: we have a massive funding problem to reverse human aging.
32:53 we must educate the public that aging is causing 100,000 deaths per day and funding biological age reversal research can change this.
36:52 Is human aging a disease?
44:10 FDA progress to treat age-related diseases/conditions.
47:38 World Health Organization ICD code progress to treat age-related diseases/conditions.
50:02 Trans-NIH Geroscience Interest Group (GSIG)
54:40 “triangular log jam” of funding with governments, scientists and public opinion.
56:30 Aubrey shares why SENS still exists.
1:00:38 Ethereum cryptocurrency founder Vitalik Buterin & other SENS donors.
1:01:55 Undoing Aging is a conference held every spring in Berlin, Germany.
1:04:53 July 2019 is Aubrey’s 2-year anniversary at AgeX as the VP of New Technology Discovery.
1:08:44 Jeff Bezos donated $100 million to Unity Biotechnology, Inc. (not Human Longevity Inc.) in 2018.
1:11:02 (Larry) Ellison Medical Foundation failure in reversing human aging.
1:14:15 Google co-founders creating Calico rather than investing in or donating to SENS
1:21: Aubrey shares details about his lifestyle as well as his recommendations for a healthy lifestyle.
1:24:25 Aubrey looks up to the longevity “foot soldiers“
1:28:42 do what you love as much as you can to avoid excess mental, physical and emotional stress.
1:30:40 Aubrey is following all longevity therapies to determine their safety & effectiveness.
1:32:20 my stem cells story & Aubrey’s feedback.
1:34:58 EmCell in Kyiv, Ukraine is the only company doing fetal stem cells therapy.
1:39:20 exosomes
1:41:00 I’ve had no reply from Ambrosia founder Jesse Karmazin since October 2018.
1:42:51 My March 26, 2019 interview with Dr. Ed Park at Recharge Biomedical: https://www.youtube.com/watch?v=xHgfYKsH0uw&list=UUCwpkla04t…qA&index=6
1:44:31 NAD+
1:47:39 gene therapy
1:53:37 please network on the internet & in person with other longevity enthusiasts to help grow this movement faster.
1:58:48 mitochondria
2:00:48 long lived animals
2:01:49 consider a donation to SENS

- Forever Labs 1 year free cryogenic storage discount code ($250 value): BN801