A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer’s disease.
Proteostasis
Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do, is a natural function of the human body, and it is known as proteostasis. However, as we age, this function degrades, and loss of proteostasis is one of the hallmarks of aging. The resulting accumulation of aggregates leads to several deadly diseases, one of which is Alzheimer’s.
Aging is just natural, while rejuvenation therapies aren’t, but does this mean we should accept aging as it is and forget about rejuvenation? Not at all, and as Nicola explains in this video, just because something is natural, it’s not also automatically good for you.
At 100 years old, the world’s oldest billionaire would be forgiven for taking it easy and enjoying the riches of his eight-decade career.
But for Chang Yun Chung, founder of Pacific International Lines (PIL), staying at home isn’t an option. Despite handing over the role of executive chairman to his son, Teo Siong Seng, earlier this year, the centenarian Singaporean insists on going into the office every day.
“It’s my habit,” Chang told CNBC in a recent episode of “Managing Asia.”
Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.
“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”
An all-star panel of experts in nutritional studies with an emphasis on longevity. At some point in your life, you have heard the following. “Eat the right food. It will help you live longer.” What if I told you the right food could help you heal as well. This panel of longevity driven nutritionist will give you a broad range of fact-based regiments and compelling individual opinions on Nutrition and longevity. This segment will cover many diverse understandable methods that can make a change in longevity for you or your loved ones. Fill yourself with the knowledge of proper nutrition for longevity.
Speakers Will Include: Brian Clement – Plant-Based & founder of “Hippocrates Health Institute” A typical American growing up in the New Jersey/New York area, Brian likes to joke that he was a pioneer in the field of obesity—he was fat even before many Americans were fat! Raised in an Irish household on the standard American diet of meat, processed foods, and sugary sodas, he was unfit and gasping for air every few steps. When he was 20 years old, he was dating a girl whose best friend’s boyfriend was 30—and a vegetarian. Despite the fact he had been more or less educated by his family that the body would die without animal-based foods, the lure of an influential peer inspired him to give up meat in one fell swoop. For the first year and a half, he kept his vegetarian diet a secret from his family. Yet after losing 120 pounds and experiencing the difference in his health, he came out of the proverbial closet (much to his family’s dismay!) and became a complete vegan three years later.
Wendi Blum – Founder of “Founder of Create Your Best Life” Wendi Blum worked in the pharmaceutical industry for over 20 years until (at age 45) felt a calling to completely change every aspect of her life. After two decades in a successful sales career (having worked for Zenecca Pharmaceuticals, PDI and Bristol Myers Squibb, wearing many different hats including advocacy, sales, and training) Wendi decided to re-write the story of her life literally and become an international inspirational speaker, author, workshop leader, success coach, and life-shift retreat guru. She is the author of 5 books – known for her focus on reinvention, goal mastery, and business savvy – she is known as “the queen of reinvention” Her titles include: “Your Life, Your Destiny, Uncover Yours, LifeShift” and “Goals Setting Workbook: Success Strategies for The New Economy” – and many more. Blum is known for her blend of Spiritual flare with business savvy” because of how she merges these two powerful components together.
Bill Faloon — Director and Co-founder of the “Life Extension Foundation”.
Bill Faloon compiled the 1,500-page medical reference book Disease Prevention and Treatment, and his latest book is Pharmocracy: How Corrupt Deals and Misguided Medical Regulations Are Bankrupting America—and What to Do About It. He is also director and co-founder of the Life Extension Foundation, a consumer advocacy organization that funds research and disseminates information to consumers about optimal health. Mr. Faloon has made hundreds of media appearances, including guest spots on The Phil Donohue Show, Tony Brown’s Journal, and ABC News Day One, and has been interviewed Newsweek and other magazines.
There is so little food in the mud at the bottom of the Pacific Ocean that individual microbes living there use just 0.00000000001 joules of energy each year.
There are certain enzymes — proteins — plaques that help cause Alzheimer’s, just recently in fact {which I as most could have told them} the gut microbes and mouth microbes are found to assist in Dementia and Alzheimers. But I and Hippocrates as others have been declaring that fact for quite some time… Respect AEWR wherein the amazing gathered data of mankind has yielded the many causes and a cure for aging…
For decades, research into Alzheimer’s has made slow progress, but now a mother and daughter team think they have finally found a solution – a vaccine that could inoculate potential sufferers.
Another great addition to #RAADfest2019 #cureaging #NAD #superlongevity
Dr. Nichola Conlon, Nuchido CEO & Co-founder, chats with James Strole, Director of the Coalition for Radical Life Extension, about what she’s bringing to RAADfest 2019: Increasing NAD+ levels in middle-aged people to a level comparable with people 17 years younger with the data to back it up.
Nuchido has pioneered the use of systems pharmacology and clinical research to boost and maintain NAD. In a scientific world-first, the team achieved the biggest increase of NAD in humans reported by any scientific group.
Hear what she has to share, and meet her at RAADfest 2019:
Until the day he died, in 2011, Robert Ettinger hoped humanity would figure out a way to cheat death. Today, his body is stored in a chamber filled with liquid nitrogen and frozen to −196 °C. He lies in cryopreservation at the Cryonics Institute in Michigan—which he founded—alongside his late mother, his first and second wives, and 150 other deceased.
Ettinger, known as the “father of cryonics,” popularized the idea in his 1962 book The Prospect of Immortality. (Isaac Asimov, the renowned biochemist and science-fiction writer, helped Ettinger publish the book.) Cryonicists believe that technology will sufficiently advance to a point where cells can be rejuvenated and the aging process reversed. In practice, legally deceased patients arrive at a cryonics facility packed in ice. Cryonicists interrupt the dying process by draining the blood from the body and perfusing the corpse with a mixture of anti-freeze and organ-preserving chemicals, known as cryoprotective agents. The body is then transformed into a vitrified state and lowered into a below-freezing chamber filled with liquid nitrogen, where it lies in wait for a future generation to restore it.
“We Will Live Again” was directed by Myles Kane and Josh Koury (http://www.brooklynundergroundfilms.com). It is part of The Atlantic Selects, an online showcase of short documentaries from independent creators, curated by The Atlantic.
