In showing how an enzyme halts cell division by producing reactive oxygen species, scientists shed new light on the biology of aging and related diseases.
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Category: life extension – Page 450
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Hosted by John Lewis of Oisin. Panel title: “A Therapeutic Revolution Against Aging”.
Aubrey de Grey, Judy Campisi, Nir Barzilai in a panel titled “A Therapeutic Revolution Against Aging”. Hosted by John Lewis of Oisin.
This was an excellent panel! Topics included Yamanaka factors, epigenetic rollback, partial reprogramming and many more. Judy disagreed with Aubrey on the nature of aging, Nir brought up a great point about the secret to rejuvenation lying in uncovering just how a 50-year old egg cell becomes a new rejuvenated baby, and even a paper on Jeanne Calment was mentioned!
As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby cells to enter the same senescent state.
Their presence causes many problems: they degrade tissue function, increase levels of chronic inflammation, and can even eventually raise the risk of cancer. Today, we will talk about what senescent cells are, how they contribute to age-related diseases, and, perhaps most importantly, what science is hoping to do about the problem.
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Ending Age-Related Diseases — October 3, 2018.
This is a video from the Ending Age-Related Diseases 2018 conference, which was held earlier this year at the Cooper Union in New York City. The conference was designed to bring the worlds of research and investment together in one place and explore the progress and challenges that the industry faces in developing and funding therapies to end age-related disease.
This was the second panel during the conference and featured Dr. Aubrey de Grey of the SENS Research Foundation, Keith Comito of Lifespan.io, Dr. James Peyer of Apollo Ventures, Dr. Mark Hammond of Deep Science Ventures, Joe Betts Lacroix of Y Combinator and Vium, Dr. Oliver Medvedik of Lifespan.io and The Cooper Union, and Ramphis Castro of ScienceVest.
Life Extension Advocacy Foundation Website — https://www.leafscience.org/
A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan.
The epigenetic clock
As we age, our DNA experiences chemical changes called DNA methylation (DNAm); these changes are used as a way to measure age and are the basis of the epigenetic clock. As we age, the methylation patterns present on our DNA change, and researchers can measure these changes to work out how old an animal or person is.
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(Advances in science and public health are increasing longevity and enhancing the quality of life for people around the world. In this series of interviews with the Milken Institute Center for the Future of Aging, 14 visionaries are revealing exciting trends and insights regarding healthy longevity, sharing their vision for a better future. The Longevity Innovators interviews highlight new discoveries in biomedical and psychosocial science, as well as strategies to promote prevention and wellness for older adults. This is the last story in the series.)
Director of the Longevity Genes Project at the Albert Einstein College of Medicine, Dr. Nir Barzilai has discovered several longevity genes in humans that appear to protect centenarians against major age-related diseases. Barzilai is also co-founder of CohBar, a biotech company developing mitochondria-based therapeutics to treat diseases associated with aging. In an interview with the Milken Institute Center for the Future of Aging, Barzilai explains why some people have longevity genes and the challenges in drug design for age-related diseases:
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Celebrate Bedford Day, a celebration of the first human to be placed into cryonic suspension.
Dr. James Bedford is the oldest person currently in Cryostasis.
On Jan. 12, 1967, James Bedford, a psychology professor at Glendale College in California who had just died of cancer, took his first step toward coming back to life. On that day, the professor became the first person ever frozen in cryonic suspension, embedded in liquid nitrogen at minus-321 degrees Fahrenheit.
Ben Best will give a presentation on:
Demonstrating the preservation of cells after a living organism is pronounced dead and revived is not a traditional bioart topic. But it is an important one. It is a crucial step for advances in the use of lowered temperatures for sustaining the efficacy of organs and organisms during medical procedures, and especially of preserving neurons for the science cryonics.
My recent bioart research is a breakthrough that will help to build momentum toward more advanced studies on information storage within the brain, as well as short-term behaviors of episodic, semantic, procedural, and working memory.
In this article, I will review how I became involved in this research, the guidance along the way, my initial training at 21st Century Medicine, pitching the research project to Alcor, and submitting my proposal to its Research Center (ARC). I will then take you into the lab, the process of trial and error in our first studies, developing a protocol based on olfactory imprinting and applying several cryopreservation methods, developing the migration index, and the rewards of working with a lab technician who became an admiral colleague.
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You can freeze them, burn them, dry them out or even blast them into space, but humble tardigrades can survive it all.
As a demonstration of tardigrade power, a new experiment has shown that even locking the critters in a block of ice for three decades fails to deliver the ultimate knockout.
Japanese researchers successfully brought two tardigrades — often called “water bears” for their claws and head shape — back to life after being frozen for 30 years. A separate team of Japanese researchers with the 24th Japanese Antarctic Research Expedition discovered the eight-legged, microscopic pair of animals back in 1983 in a frozen sample of moss, which was kept below freezing to the present day.
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A new antibiotic developed by a Flinders University researcher is being heralded as a breakthrough in the war against a drug resistant superbug. Bacteria are winning the fight against antibiotics as they evolve to fight off traditional treatments, threatening decades of advancements in modern medicine, with predictions they will kill over 10 million people by 2050. The scientific development of new, effective and safe antibiotics is crucial in addressing the ever-growing threat posed by drug resistant bacteria around the world.
Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time, particularly in Australia’s ageing population. Dr Ramiz Boulos, adjunct research associate at Flinders University and CEO of Boulos & Cooper Pharmaceuticsals, says the fact CDI is becoming resistant to traditional antibiotics is alarming and highlights the need to develop more effective treatments.
“Cases of CDI disease are rising and the strains are becoming more lethal. If there is an imbalance in your intestines it can begin to grow and release toxins that attack the lining of the intestines which leads to symptoms,” says Dr Boulos. Over the past ten years, various strains of C. difficile have emerged, and are associated with outbreaks of severe infections worldwide. One particular strain is easily transmitted between people and has been responsible for large outbreaks in hospitals in the United States and Europe. “It’s concerning when you consider CDI is one of the most common infections acquired during hospital visits in the Western hemisphere, and the most likely cause of diarrhea for patients and staff in hospitals.”
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