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Category: life extension – Page 451

A New Healthcare Framework for Aging Populations

A new publication by an international team of scientists has proposed a new healthcare framework to help older people stay healthier for longer by improving the development of therapies that target age-related diseases.

Society is aging, and we need to change healthcare for the better

This new publication urges World Health Organization (WHO), governments, and the medical science community to work together and develop classifications and staging systems using a new framework as a basis for diagnosing and treating age-related diseases.

The DNA Damage Response in Aging

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging.

The role of DNA damage

Some researchers have long suggested that damage to our DNA is a major reason why we age and a strong determinant of species longevity; indeed, many-long lived species have extremely stable genomes, such as bristlecone pines, which have lifespans of over 5000 years.

Tryptophan as a Therapeutic Target for Inflammaging

A new open access paper takes a look at tryptophan and the role that it plays in the dysfunction of the immune system in the context of the age-related changes that occur in the microbiome [1].

The microbiome

The gut microbiome is a complex ecosystem of bacteria, archaea, eukarya, and viruses that live inside of us, some beneficial and some harmful, the balance of which keeps us alive. Four microbial phyla, Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria, make up 98% of the total population of the intestinal microbiome.

Alzheimer’s drug candidates reverse broader aging, study shows

In mouse models of Alzheimer’s disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. Now, Salk researchers have shown how these compounds can also slow aging in healthy older mice, blocking the damage to brain cells that normally occurs during aging and restoring the levels of specific molecules to those seen in younger brains.

The research, published last month in the journal eLife, suggests that the drug candidates may be useful for treating a broader array of conditions and points out a new pathway that links normal aging to Alzheimer’s disease.

“This study further validated these two compounds not only as Alzheimer’s drug candidates but also as potentially more widely useful for their anti-aging effects,” says Pamela Maher, a senior staff scientist at Salk and a co-corresponding author of the new paper.

Nanotech Suggests To Have Found A Way To Combat Age Related Diseases

NaNotics, in another breakthrough, is promising a new kind of medication, and suggests to have found a way to combat age related diseases; boldly going where no nanotech has gone before.

Lou Hawthorne of NaNotics, LLC opened his presentation at a recent longevity investor event using a clip from Star Trek that shows captain Kirk being giving a shot that restores him to his younger years.

“It’s tempting to assume it’s a drug, but what if the content of that syringe was something new?” NaNotics’ CEO Hawthorne asked. “NaNots are a new class of medicine. They are engineered to do just one thing and that’s the holy grail of medicine design, because most drugs do two things: something you want them to do, and something you don’t. In other words, side effects.”

Gut Microbes Support Neurogenesis and Longevity Hormone Production

The relationship between health and the microorganisms living in the gut has increasingly reached the spotlight in the last few years, and a new study led by researchers at Nanyang Technological University, Singapore (NTU Singapore) sheds more light on the gut microbiome and how it can influence aging.

The gut microbiome

The gut microbiome is a complex ecosystem that includes a varied community of bacteria, archaea, eukarya, and viruses that inhabit our guts. The four bacterial phyla of Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria comprise 98% of the intestinal microbiome.

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