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Category: life extension – Page 454
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without the diseases of aging.
We were glad to have the opportunity to conduct a joint interview with Dr. Kelsey Moody and Dr. Huda Suliman. They offered several keen insights on the future of Ichor Therapeutics and the nature of the rejuvenation biotechnology industry.
K: I’m Dr. Kelsey Moody. I’m the Chief Executive Officer of Ichor Therapeutics and its portfolio of companies. Ichor itself is a biopharmaceutical company that does drug discovery in the aging space, and we have a variety of portfolio companies, each of which is designed to target a different type of age-associated damage. Through these companies, we’re developing classes of different drugs to move into the clinic for conventional therapeutic applications as well as, hopefully, more anti-aging targeted therapies as well.
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At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without age-related diseases.
We even had the chance to interview the well-known Dr. Aubrey de Grey, whose organization, the SENS Research Foundation, partnered with Forever Healthy Foundation to make Undoing Aging 2019 a reality. We asked him questions about how far SENS has come as an organization and what we can expect from future conferences.
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“Ruby, along with her company Applied Stem Cell, is one of the world’s most respected experts in gene editing. We are delighted to be working with her on our ambitious project to transform the potential of somatic gene therapy, in terms of both its safety from creating unwanted mutations and its efficacy in delivering large amounts of DNA, which is founded on some pioneering work at Stanford in which she was also heavily involved.” says Aubrey de Grey.
https://www.undoing-aging.org/news/dr-ruby-yanru-chen-tsai-t…b5IQ0dQ64s
#undoingaging #sens #foreverhealthy
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In a stunning piece of research, Stanford neuroscientists have hunted down a single gene that encodes a protein responsible for age-related cognitive losses, targeted it with special blocking antibodies, and shown in mice that these antibodies can rejuvenate old brains to work as well as young ones.
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Instead of throwing away your broken boots or cracked toys, why not let them fix themselves? Researchers at the University of Southern California Viterbi School of Engineering have developed 3D-printed rubber materials that can do just that.
Assistant Professor Qiming Wang works in the world of 3D printed materials, creating new functions for a variety of purposes, from flexible electronics to sound control. Now, working with Viterbi students Kunhao Yu, An Xin, and Haixu Du, and University of Connecticut Assistant Professor Ying Li, they have made a new material that can be manufactured quickly and is able to repair itself if it becomes fractured or punctured. This material could be game-changing for industries like shoes, tires, soft robotics, and even electronics, decreasing manufacturing time while increasing product durability and longevity.
The material is manufactured using a 3D printing method that uses photopolymerization. This process uses light to solidify a liquid resin in a desired shape or geometry. To make it self-healable, they had to dive a little deeper into the chemistry behind the material.
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A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains.
Searching for the cause of cognitive decline
Microglia are immune cells that reside in the brain and spinal cord. These cells mediate immune responses in the central nervous system and act like other macrophages, clearing cellular debris and dead neurons from nervous tissue through the process of phagocytosis (cell eating).
The memory of older people has been returned to the state of someone in their 20s for the first time by applying electrical stimulation to the brain to reconnect faulty circuits.
Scientists at Boston University in the US have proven it is possible to restore working memory by ‘recoupling’ areas of the brain which have become out-of-sync as people grow older.
Short-term working memory is crucial for everyday life, storing information for around 10 — 15 seconds to allow problem solving, reasoning, planning and decision making, allowing someone, for example, to keep a telephone number in mind while writing it down.
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In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1].
Senescent cells and senolytics
As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful inflammatory chemical signals, which are known as the senescence associated secretory phenotype (SASP). The SASP can also encourage other nearby healthy cells to also enter the same senescent state.
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Beauty might only be skin deep, but for those wondering how to keep that skin young, scientists may have found an answer in the form of a protein that encourages cell competition.
The prosaically named COL17A1 might not sound like a fountain of youth, but the new study suggests it does the heavy lifting when it comes to keeping skin intact and unimpaired.
The protein works by encouraging cell competition, a key process to maintain tissue fitness. That effectively “drives out” weaker cells while encouraging replication of stronger ones.
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